Aging, Mitochondria, and Antioxidants
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 398
Special Issue Editors
2. Medical Service, Department of Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
Interests: ischemia-reperfusion; electron transport complex I; aging heart; cardiolipin; mitochondrial calpain; heart; myocardial infarction; electron transport complex III; cytochrome oxidase; mitochondria
Special Issues, Collections and Topics in MDPI journals
Interests: oxidative stress; mitochondrial dysfunction and ROS generation during aging; ER stress; heart failure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The elderly population is continually increasing worldwide due to increased life expectancy. The major challenge for elders is an increased occurrence of heart failure due to augmented cell injury in response to superimposed acute cardiac diseases, including acute myocardial infarction, increases in left ventricular afterload due to aortic stenosis or hypertension, chemotherapeutic agent cardiotoxicity, catecholamine-induced stress, or cardiac ischemia secondary to exogenous cardiac disease such as sepsis. Elderly patients sustain larger infarcts with greater mortality following the acute ischemia–reperfusion of acute coronary syndromes and their treatment. Increased cardiac injury with advanced age has also been shown in animal models. Many studies show that mitochondrial dysfunction has a pivotal role in the increased susceptibility to cellular injury in the aging heart. Although mitochondria are critical to maintaining normal cardiac function because they provide a constant energy supply and support metabolic homeostasis, dysfunctional mitochondria are key sources of cardiac injury in pathologic settings. Damaged mitochondria not only decrease energy supply, but also increase the generation of reactive oxygen species (ROS) and favor the opening of the mitochondrial permeability transition pore that contributes to cardiac injury. The mitochondrial electron transport chain (ETC) is a key site of ROS generation. Many studies show that aging impairs the ETC in a manner that increases ROS generation. ROS production is also regulated by a system of antioxidant enzymes. Aging also potentially leads to decreased antioxidant capability in cardiac mitochondria. Thus, oxidative stress during aging can be due to increased ROS generation from dysfunctional mitochondria or decreased antioxidant effect—especially antioxidant enzymes located within the mitochondria. Interestingly, recent studies show that age-induced mitochondrial defects in the ETC can be improved. Treatments including the supplementation of metformin, 4-PBA, and SS-31 can improve mitochondrial function in aged heart mitochondria. The effects of these treatments on antioxidants in aged heart mitochondria need to be studied further. We anticipate that more treatment options can be used to improve aging-induced mitochondrial dysfunction.
In this Special Issue, we invite original research articles on research linked to potential strategies targeted to improve mitochondrial function in aged hearts, especially by decreasing ROS generation or increasing antioxidant function, especially in the alteration of PRDXs, GRX2, and p66shc. All manuscripts should be submitted online.
Dr. Edward Lesnefsky
Dr. Qun Chen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- mitochondrial respiratory chain
- antioxidants
- reactive oxygen species
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.