Oxidative Stress and Mitochondrial Function in Exercise and Physical Activity

Dear Colleagues,

Several chronic diseases are related to oxidative stress and are highly related to a higher incidence of sedentarism and inactivity. Several groups have postulated that exercise and physical activity represent good strategies for promoting health and fighting chronic diseases including hypertension, heart failure, myocardial infarction, diabetes, anxiety, and depression, among others. Exercise is also an important tool for stimulating several intracellular cascades that culminate in an increase in proteins and active molecules that are capable of interacting with a higher rate of production of reactive oxygen species (ROS). Therefore, the more we can stimulate antioxidant defenses, the lower the probability of inducing oxidative damage in cellular components. It is well known that the main site where ROS are produced is in the mitochondria; therefore, a homeostatic imbalance in the function of this organelle is associated with an increase in ROS and the establishment of oxidative stress. In this Special Issue, we aim to share research focusing on the effects of physical activity, physical exercise, and training to promote health and counterbalance the deleterious effects of ROS production and oxidative damage associated with the mitochondrial dysfunction induced by inappropriate lifestyles (sedentarism, overnutrition, smoking, alcohol consumption, drug abuse, etc.). With this in mind, we welcome studies that have investigated the outcomes of physical activity, sedentary behavior, and physical exercise and training associated with oxidative stress biomarkers (in lipids, proteins, or DNA) in experimental or clinical studies (involving mice, rats, children, adolescents, adults, older adults, or gender differences) in physiological or disease-related conditions. Our objective in this Special Issue of Antioxidants is to highlight the relevance of the expanding efficacy of physical activity and exercise against chronic diseases.

As Guest Editor, I invite you to contribute to the Special Issue on “Oxidative Stress and Mitochondrial Function in Exercise and Physical Activity”. Original research reports and reviews will be published online in Antioxidants.

Dr. Cláudia Jacques Lagranha
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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• mitochondrial function
• oxidative stress
• diseases
• exercise
• physical activity