Natural Antioxidants in Pharmaceuticals and Dermatocosmetology

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 492

Special Issue Editor


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Guest Editor
Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square, No. 2, 300041 Timişoara, Romania
Interests: phytochemical characterization; extraction, isolation and characterization of pure bioactive compounds from plants extracts; assessment of the biological activity of plant extracts/pure active phytochemicals; in vitro, in vivo evaluations; clinical trials
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Special Issue Information

Dear Colleagues,

To date, a significant number of pharmaceuticals and dermatocosmetic products have natural compounds as their main active ingredients, available in various forms of extracts (standardized or not) or as pure phytochemicals. Furthermore, there is growing use of these products among the population. The connection between the antioxidant activity of natural compounds and their multitude of beneficial effects for health and dermatocosmetology is strongly validated and substantiated.

The aim of this Special Issue is to present the latest findings on natural antioxidants that can be used in the pharmaceutical and dermatocosmetic fields. Submissions should include studies on active phytochemicals, whether in their pure form or as standardized extracts, that show positive results in managing acute and/or chronic pathologies. Additionally, natural antioxidant molecules that benefit the skin and hair, from both medical and esthetic perspectives, should be reported. The potential interactions of natural antioxidant compounds with synthetic molecules, whether they potentiate or inhibit their effects, should be detailed. Furthermore, the underlying mechanisms of antioxidant effects and biological activities should be thoroughly explored.

We welcome experimental and clinical research papers, as well as in-depth reviews, for this Special Issue.

Prof. Dr. Corina Danciu
Guest Editor

Manuscript Submission Information

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Keywords

  • phytochemicals
  • antioxidant
  • pharmaceuticals
  • dermatocosmetic products
  • in vitro and in vivo evaluations
  • clinical trials

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Published Papers (1 paper)

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Review

34 pages, 17924 KiB  
Review
Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action
by Wioleta Żynda, Agnieszka Ruczaj and Anna Galicka
Antioxidants 2025, 14(4), 389; https://doi.org/10.3390/antiox14040389 - 26 Mar 2025
Viewed by 162
Abstract
The skin, as the largest external organ, is exposed to many environmental factors, such as sunlight and pollution, as well as some synthetic ingredients in cosmetic products used in excess by most people of all ages throughout their lives. Under the influence of [...] Read more.
The skin, as the largest external organ, is exposed to many environmental factors, such as sunlight and pollution, as well as some synthetic ingredients in cosmetic products used in excess by most people of all ages throughout their lives. Under the influence of these factors and with age, the amount of the key building protein, collagen type I, decreases, which leads to a deterioration in the appearance and condition of the skin. Currently, when the average life expectancy increases, the esthetic aspect and maintaining healthy skin are particularly important. In the cosmetic and pharmaceutical industries, attempts have long been made to prevent skin aging by the application of products containing natural compounds, mainly due to their high antioxidant activity. This review collects natural compounds, mainly polyphenols, with stimulating and protective effects on collagen type I in human skin fibroblasts, along with a description of the mechanisms of their action. Some of them have been tested on mice and rats, as well as in clinical trials, and in most cases, the results have been very promising. Nevertheless, there is still a need for an intensification of clinical studies in order to determine their appropriate dosage, safety, and effectiveness. Full article
(This article belongs to the Special Issue Natural Antioxidants in Pharmaceuticals and Dermatocosmetology)
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