Oxidative DNA Damage and Mechanism of Aging in Insects
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 4485
Special Issue Editor
Interests: Drosophila; development; DNA repair; oxidative stress; aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recently, many studies have revealed the molecular mechanism of oxidative DNA damage repair, mainly using cultured mammalian cells and unicellular organisms such as yeast and bacteria. Furthermore, other recent studies have argued a relationship between oxidative DNA damage and a progression of aging; although, the theory that the accumulation of reactive oxygen species in internal organs is a major promoter of aging has been considered negatively. However, aging studies using mammalian models take longer to obtain a conclusion. On the contrary, insects have an advantage to studies on oxidative DNA damage at the organism level and the mechanism of aging, due to their rapid growth, shorter lifespan, and lower experimental costs. For example, in the fruit fly Drosophila melanogaster, the most advanced genetic techniques that facilitate experimental investigation at cellular and organism levels have been established. In the past, this organism has been used in many studies to investigate the mechanisms of DNA repair. Recent studies have identified Drosophila orthologs of many essential genes for the repair of DNA damage, including oxidative DNA damage, in other organisms. These findings enhance the value of this organism as a model for investigations on DNA damage repair and aging at the organism level.
Therefore, we have planned a Special Issue entitled “Oxidative DNA Damage and Mechanism of Aging in Insects”. Manuscripts that deal with genes and proteins related to oxidative DNA damage repair and a relationship between oxidative DNA damage and aging that appears in insects are required for submission.
Dr. Yosihhiro Inoue
Guest Editor
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Keywords
- DNA repair mechanisms
- Oxidative stress response
- Ageing
- Insects as models for Oxidative DNA Damage and Mechanism of Aging
- Screening of Antioxidants using Insect models
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