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Antioxidants
Special Issues
Oxidative Stress in Fish
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Oxidative Stress in Fish

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 6809

Special Issue Editor

Prof. Dr. Leonardo José Gil Barcellos

E-Mail Website
Guest Editor
Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, BR 285, Passo Fundo 99052-900, RS, Brazil
Interests: animal physiology; fish; oxidative stress; Oxidative stress as a mechanism of toxicity

Special Issue Information

Dear Colleagues,

Oxidation processes occur all the time—whether in humans, animals in general or even in plants, everything that is alive oxidizes. The result of oxidation processes is compensated by the body's antioxidant systems: when some physiological imbalance occurs, either endogenously or environmentally, oxidative control can be drastically altered. Many diseases that still do not have a clarified etiology are related to the establishment of oxidative stress, given by the increase in reactive oxygen species (ROS) or nitrogen (RNS). To understand oxidation and reduction processes, different live models are applied in research, with fish being a great model for oxidative studies. Fish in general, due to the environment in which they live (water), are often affected by contaminants for human use that end up reaching wastewater. This contamination can affect their development and put the species at risk. Many of the behavioral changes observed in fish research are related to high levels of oxidative stress, and thus, many disorders of animal behavior that are still poorly understood may be related to oxidative imbalance. In addition, in intensive fish production systems, due to abiotic stresses (sound, density, chemical or procedural), this can end up increasing levels of oxidative stress, resulting in productivity losses.

In this Special Issue, we aim to address the novelty involving oxidative stress in fish and highlight the causal and progression relationships of different comorbidities in humans or in animals that can compromise the survival of nontarget species in the environment as well as result in lack of production in intensive production of fish.

Prof. Dr. Leonardo José Gil Barcellos
Guest Editor

Manuscript Submission Information

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Keywords

  • oxidative stress as a mechanism of toxicity
  • oxidative stress biomarkers in fish
  • oxidative stress and behavior
  • antioxidant compounds on oxidative damage
  • oxidative stress on neuronal damage and alterations

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Published Papers (3 papers)

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Research

19 pages, 7016 KiB  
Article
Chronic Effects of Carbamazepine, Progesterone and Their Mixtures at Environmentally Relevant Concentrations on Biochemical Markers of Zebrafish (Danio rerio)
by András Ács, Xinyue Liang, Illés Bock, Jeffrey Griffitts, Bence Ivánovics, Erna Vásárhelyi, Árpád Ferincz, Zsolt Pirger, Béla Urbányi and Zsolt Csenki
Antioxidants 2022, 11(9), 1776; https://doi.org/10.3390/antiox11091776 - 8 Sep 2022
Cited by 4 | Viewed by 1985
Abstract
The impact of pharmaceuticals on non-target organisms in the environment is of increasing concern and study. Pharmaceuticals and other pollutants are often present as mixtures in an environmental compartment. Studies on the toxicological implications of these drugs on fish, particularly as mixtures at [...] Read more.
The impact of pharmaceuticals on non-target organisms in the environment is of increasing concern and study. Pharmaceuticals and other pollutants are often present as mixtures in an environmental compartment. Studies on the toxicological implications of these drugs on fish, particularly as mixtures at environmentally relevant concentrations, are very limited. Thus, this study aimed to evaluate the chronic effects of the anticonvulsant drug carbamazepine (CBZ) and progesterone (P4) at environmentally relevant concentrations, individually and in binary mixtures, applying a suite of biomarkers at the molecular level in zebrafish (Danio rerio). The effects on biotransformation enzymes 7-ethoxyresorufin O-deethylase (EROD) and glutathione-S-transferase (GST), antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione peroxidases (GPxSe and GPxTOT), and glutathione reductase (GR), and markers of damage, such as DNA strand breaks (DNAsb), lactate dehydrogenase (LDH), lipid peroxidation (LPO), and vitellogenin-like proteins (VTG), were evaluated. Analyses of the biochemical markers indicated that a synergistic dose-ratio-dependent effect of CBZ and P4 in zebrafish occurs after chronic exposure regarding VTG, biotransformation enzymes (EROD, GST), and oxidative stress marker (DNAsb). The results suggest a synergistic effect regarding VTG, thus indicating a high risk to the reproductive success of fish if these pharmaceuticals co-occur. Full article
(This article belongs to the Special Issue Oxidative Stress in Fish)
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16 pages, 3189 KiB  
Article
Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)
by Wagner Antonio Tamagno, Carla Alves, Diego Tessaro, Nathália Tafarel Sutorillo, Wallace Santin and Leonardo José Gil Barcellos
Antioxidants 2022, 11(8), 1507; https://doi.org/10.3390/antiox11081507 - 31 Jul 2022
Cited by 3 | Viewed by 2196
Abstract
Ilex paraguariensis (Herb mate) is a native plant from South America, widely consumed through the infusion of dried leaves. The presence of antioxidant properties in herb mate may be relevant and contribute to evaluating the effect of its compounds against oxidative stress, which [...] Read more.
Ilex paraguariensis (Herb mate) is a native plant from South America, widely consumed through the infusion of dried leaves. The presence of antioxidant properties in herb mate may be relevant and contribute to evaluating the effect of its compounds against oxidative stress, which could cause neurodegenerative diseases. Despite having health benefits, there are reports of the presence of heavy metals in extracts obtained from the infusion. One of these metals is iron (Fe), found in large amounts in herb mate. To reverse the cumulative effects of metals and Fe in the body, the use of Deferoxamine (Dfx) is indicated, being a potent chelator of Fe. In this work, we aimed to evaluate the antioxidant potential of the micro-encapsulated extract of I. paraguariensis (MEIP) supplemented with Dfx on zebrafish behavior and biochemical biomarkers. To evaluate the effect per se and the supplementation, four groups were established: the first group was the control (water); the second, fish treated with MEIP; the third group was formed of fish treated with Dfx; while the fourth group was treated with both MEIP and Dfx. When applied alone, Dfx presents an anxiogenic-like pattern on zebrafish (Danio rerio), while the MEIP shows an anxiolytic-like behavior. The antioxidant enzymes are re-modulated close to control when the MEIP + Dfx is applied. The cholinergic system shows an activation of the signaling, as well as the heme radical group formation, which is not affected by the Dfx-chelating effect. Thus, the supplementation of MEIP with Dfx is important to transform this extract into one that is safer and healthier for human consumption. Full article
(This article belongs to the Special Issue Oxidative Stress in Fish)
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15 pages, 2030 KiB  
Article
Biochemical Marker Assessment of Chronic Carbamazepine Exposure at Environmentally Relevant Concentrations in Juvenile Common Carp (Cyprinus carpio)
by Xinyue Liang, Zsolt Csenki, Bence Ivánovics, Illés Bock, Balázs Csorbai, József Molnár, Erna Vásárhelyi, Jeffrey Griffitts, Árpád Ferincz, Béla Urbányi and András Ács
Antioxidants 2022, 11(6), 1136; https://doi.org/10.3390/antiox11061136 - 9 Jun 2022
Cited by 6 | Viewed by 1950
Abstract
Worldwide, the anticonvulsant drug carbamazepine (CBZ) is the most frequently identified pharmaceutical residue detected in rivers. Reported chronic effects of CBZ in non-target freshwater organisms, particularly fish, include oxidative stress and damage to liver tissues. Studies on CBZ effects in fish are mostly [...] Read more.
Worldwide, the anticonvulsant drug carbamazepine (CBZ) is the most frequently identified pharmaceutical residue detected in rivers. Reported chronic effects of CBZ in non-target freshwater organisms, particularly fish, include oxidative stress and damage to liver tissues. Studies on CBZ effects in fish are mostly limited to zebrafish and rainbow trout studies. Furthermore, there are only a few chronic CBZ studies using near environmental concentrations. In this study, we provide data on subacute effects of CBZ exposure (28 days) to common carp (Cyprinus carpio), employing a set of biochemical markers of damage and exposure. CBZ was found to induce a significant change in the hepatic antioxidant status of fish subjected to 5 µg/L. Moreover, with increasing concentrations, enzymatic and non-enzymatic biomarkers of oxidative defence (catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), DNA strand breaks)), toxicant biotransformation (ethoxyresorufin-o-demethylase (EROD), glutathione-S-transferase (GST)), and organ and tissue damage (lactate dehydrogenase (LDH), cetylcholinesterase (AChE)) were altered. The AChE, LDH, and lipid peroxidation (LPO) results indicate the occurrence of apoptotic process activation and tissue damage after 28 days of exposure to CBZ. These findings suggest significant adverse effects of CBZ exposure to common carp at concentrations often found in surface waters. Full article
(This article belongs to the Special Issue Oxidative Stress in Fish)
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