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Antioxidants
Special Issues
Reactive Nitrogen Species (RNS) and Redox Signaling in Tumors
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Reactive Nitrogen Species (RNS) and Redox Signaling in Tumors

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2964

Special Issue Editors

Dr. Maria Clara Franco

E-Mail Website
Guest Editor
Center for Translational Science, Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA
Interests: tumors; oxidative stress; glioblastoma; neurodegeneration; reactive nitrogen species
Dr. Luciana Hannibal

E-Mail Website
Guest Editor
Department for Pediatrics, Medical Center, University of Freiburg, 79106 Freiburg, Germany
Interests: vitamin B12; cobalamin; inborn errors of metabolism; metabolites; homocysteine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

In the intricate landscape of tumor biology, the dynamic interplay between reactive nitrogen species (RNS) and redox signaling mechanisms has emerged as a pivotal area of exploration. This Special Issue, “Reactive Nitrogen Species (RNS) and Redox Signaling in Tumors”, serves as a dedicated forum for researchers to delve into the diverse roles played by RNS and redox signaling within the context of tumorigenesis.

By unraveling the complexities of these molecular interactions, we aim to advance our understanding of the underlying mechanisms driving cancer development. Contributions to this Special Issue will shed light on the role of RNS and redox signaling in tumor biology, exploring their impact on cellular processes, signaling pathways, and the overall progression of cancer.

We welcome both innovative research papers and insightful reviews. As we collectively and rigorously navigate this growing field, we anticipate that the insights gained will not only deepen our comprehension of tumor biology but also pave the way for innovative therapeutic strategies and diagnostic approaches.

Dr. Maria Clara Franco
Dr. Luciana Hannibal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor biology
  • reactive nitrogen species
  • redox signaling
  • oxidative stress
  • ROS

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Published Papers (1 paper)

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Review

33 pages, 3174 KiB  
Review
Oxidative Stress and Age-Related Tumors
by Emma Di Carlo and Carlo Sorrentino
Antioxidants 2024, 13(9), 1109; https://doi.org/10.3390/antiox13091109 - 13 Sep 2024
Cited by 5 | Viewed by 2690
Abstract
Oxidative stress is the result of the imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous and exogenous processes, and antioxidant defenses consisting of exogenous and endogenous molecules that protect biological systems from free radical toxicity. Oxidative stress [...] Read more.
Oxidative stress is the result of the imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous and exogenous processes, and antioxidant defenses consisting of exogenous and endogenous molecules that protect biological systems from free radical toxicity. Oxidative stress is a major factor in the aging process, contributing to the accumulation of cellular damage over time. Oxidative damage to cellular biomolecules, leads to DNA alterations, lipid peroxidation, protein oxidation, and mitochondrial dysfunction resulting in cellular senescence, immune system and tissue dysfunctions, and increased susceptibility to age-related pathologies, such as inflammatory disorders, cardiovascular and neurodegenerative diseases, diabetes, and cancer. Oxidative stress-driven DNA damage and mutations, or methylation and histone modification, which alter gene expression, are key determinants of tumor initiation, angiogenesis, metastasis, and therapy resistance. Accumulation of genetic and epigenetic damage, to which oxidative stress contributes, eventually leads to unrestrained cell proliferation, the inhibition of cell differentiation, and the evasion of cell death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, and skin cancers are the most frequent aging-associated malignancies, and oxidative stress is implicated in their pathogenesis and biological behavior. Our aim is to shed light on the molecular and cellular mechanisms that link oxidative stress, aging, and cancers, highlighting the impact of both RONS and antioxidants, provided by diet and exercise, on cellular senescence, immunity, and development of an antitumor response. The dual role of ROS as physiological regulators of cell signaling responsible for cell damage and diseases, as well as its use for anti-tumor therapeutic purposes, will also be discussed. Managing oxidative stress is crucial for promoting healthy aging and reducing the risk of age-related tumors. Full article
(This article belongs to the Special Issue Reactive Nitrogen Species (RNS) and Redox Signaling in Tumors)
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