Role of Reactive Nitrogen and Oxygen Species in Cellular Functions and Diseases

Dear Colleagues,

Nitro-oxidative stress is characterized by a pathologically elevated generation of reactive nitrogen species (RNS) (such as nitrogen monoxide (NO), nitrogen dioxide (NO₂), and peroxynitrite) as well as reactive oxygen species (ROS) (such as superoxide anion, hydrogen peroxide, hydroxyl radical, or singlet oxygen). The formation of such a reactive and, thus, potentially deleterious species is typically the result of altered cellular metabolism. Interestingly, high levels of RNS and ROS, often leading to various redox balance disorders or dysregulated redox signaling, are hallmarks of  a developing pathology or existing disease, including neurodegenerative disorders and cancer.  Depending on the cellular context, diverse reactive nitrogen species can mediate cellular signaling pathways, ultimately leading to cytotoxicity, and thus can be targeted with sophisticated molecular tools in prevention and treatment of different pathologies. This Special Issue is specifically oriented on the discussion of the role of nitric oxide derivatives in the pathogenesis of cancer and neuronal cell degeneration from a biological, chemical and biochemical point of view, cell survival mechanisms, and molecular induction of cell death.

Dr. Magdalena Gorska-Ponikowska
Dr. Narcyz Knap
Prof. Dr. Michal Wozniak
Guest Editors

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