Redox Signaling at the Crossroads of Immunity, Inflammation, Infectious Disease, and Cancer

Dear Colleague,

Reactive oxygen species (ROS) manifest effects that encompass both beneficial physiological functions as well as damaging alterations of cellular components. These two opposing effects of ROS seem to depend on the amount, location, duration, and types of ROS that are generated within the cell. Indeed, normal functioning of the immune system, both innate and adaptive mechanisms, involve acute ROS production and intricately regulated redox signaling. A dysfunctional immune system resulting from oxidative stress and chronic inflammation are now known to be responsible for the initiation, progression, and therapeutic resistance of numerous diseases. However, despite decades of research in this field, no effective therapy is currently approved for regulating altered redox signaling at the crossroads of immunity, inflammation, infectious diseases, and cancer. This Special Issue of Antioxidants will focus on the mechanisms linked to the regulation of pro- and antioxidants in both normal and pathological circumstances. In addition, this Special Issue will address druggable targets that show promise in clinical settings. Therefore, basic research, clinical case reports, as well as review articles will be accepted.

Dr. Debasis Mondal
Dr. Syed Siraj A. Quadri
Guest Editors

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