Mitochondria Biology in Reproductive Function
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 93961
Special Issue Editors
2. Infertility Service, San Salvatore Hospital, L’Aquila, Italy
Interests: ovarian aging; mitochondria; sirtuins; oxidative stress; glycative stress; male infertility
Special Issue Information
Dear Colleagues,
Mitochondria are multitasking organelles involved in a wide range of processes central to cell functions. Beyond energy generation, they are crucial for intracellular redox regulation, calcium signaling, and cell death. By integrating signaling networks, mitochondria activate an adaptive response to stress and provide the energy necessary to sustain homeostasis. Mitochondria-based events regulate different aspects of reproductive function, and mitochondrial defects are known to cause infertility. The mature oocyte has the largest number of mitochondria and mtDNA copies per cell, 2 x 105, which is significantly more than that of other cell types with high energy requirements. Disturbances in functionality and distribution of mitochondria are associated with female advanced age and metabolic stress. Since sperm mitochondria are destroyed inside the embryo, deficits in oocyte mitochondria manifest not only as reduced oocyte competence and embryo development but also contribute to post-implantation failure, long-term cell function, and adult disease. Mitochondria are crucial in many sperm functions, including motility, hyperactivation, capacitation, acrosome reaction, and fertilization; thus, their role is considered to be highly relevant to reproductive function. However, the overall mitochondrial impact on female and male fertility and the potential of therapeutic attempts to restore mitochondrial function are yet to be uncovered.
We invite you to submit research or review articles to this Special Issue, which will bring together current findings concerning mitochondrial activities involved in reproductive function under normal and diseased states as well as potential strategies to mitigate mitochondrial dysfunction. It is hoped that the Special Issue provides a useful resource and stimulates further work in this fascinating area.
Prof. Dr. Carla Tatone
Dr. Giovanna Di Emidio
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondria
- energy metabolism
- oxidative stress
- sperm
- oocyte
- reproduction
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