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Heterocyclic Compounds: Discovery, Synthesis and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 259

Special Issue Editor


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Guest Editor
1. Department of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy
2. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy
Interests: carbazole derivatives; heterocyclic compounds synthesis; antioxidants; medicinal chemistry; medicinal compounds synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Heterocyclic compounds containing sulphur, oxygen or nitrogen have attracted particular interest among researchers. Many biologically active agents, both of natural and synthetic origin, bear a heterocyclic structure (for example, ellipticine, papaverine, emetine, theophylline, atropine, codeine, reserpine, morphine, diazepam, chlorpromazine, amiodarone, bergapten and barbiturates). These compounds represent a great concern due to the attractive structural characteristics and encouraging therapeutic effects, including antitumor, antiviral, antibacterial, antimicrobial, antifungal, anti-inflammatory, pain-relieving, anxiolytic and antihistamine activity. Thus, several heterocyclic compounds possess various industrial applications, and they are used in pharmaceutical, dyes, insecticides and plastic industries. This Special Issue will publish research papers with topics including, but not limited to, the synthesis and/or application of heterocycles endowed with any biological action. We also welcome contributions that highlight the importance of the sulphur, oxygen or nitrogen-based scaffolds that are widely found in cosmetics, dyes, agrochemicals and functional materials. Therefore, in this Special Issue, we will accept research papers and review articles addressing studies on the molecular modelling, synthesis, delivery systems, biological, nutritional, phytochemical evaluation and all applications of heterocycle compounds.

Dr. Anna Caruso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • heterocyclic compounds
  • N-containing heterocycle
  • O-containing heterocycle
  • S-containing heterocycle
  • medicinal chemistry
  • drug development
  • industrial applications
  • therapeutic agent
  • biological activity

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Published Papers (1 paper)

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Review

15 pages, 1486 KiB  
Review
The Potential of Indole Alkaloids in Bone Health and Osteoporosis Management
by Anna Caruso, Virginia Caira, Hussein El-Kashef and Carmela Saturnino
Appl. Sci. 2024, 14(18), 8124; https://doi.org/10.3390/app14188124 - 10 Sep 2024
Viewed by 205
Abstract
Indole alkaloids, a class of plant-derived nitrogen-containing compounds, have emerged as promising candidates for osteoporosis treatment. Their favorable biocompatibility profile demonstrated efficacy in preclinical models, and low reported toxicity make them attractive alternatives to existing therapies. This review focuses on the therapeutic potential [...] Read more.
Indole alkaloids, a class of plant-derived nitrogen-containing compounds, have emerged as promising candidates for osteoporosis treatment. Their favorable biocompatibility profile demonstrated efficacy in preclinical models, and low reported toxicity make them attractive alternatives to existing therapies. This review focuses on the therapeutic potential of specific indole alkaloids, including vindoline, rutaecarpine, harmine, and its derivatives, in promoting bone health and managing osteoporosis. Full article
(This article belongs to the Special Issue Heterocyclic Compounds: Discovery, Synthesis and Applications)
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