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Indole Derivatives as Tools in New Drug Development

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 619

Special Issue Editor


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Guest Editor
Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata, Italy
Interests: carbazole derivatives; heterocyclic compounds synthesis; antioxidants; medicinal chemistry; medicinal compounds synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Today, indole derivatives constitute an important and versatile class of heterocycles, especially due to their interesting chemical and biological properties, such as antitumor, antiviral, antibacterial, antimicrobial, antifungal, anti-inflammatory, and antihistamine activity. Several indoles, whether synthetic or naturally occurring, possess various industrial applications, and they are used in the pharmaceutical, dye, insecticide, and plastic industries. This Special Issue covers all aspects of the different indole derivatives—for example, benzoindoles, pyranoindoles, indole-carboxylates, carbazoles, and staurosporines. In this Special Issue, research papers and review articles addressing recent studies on the molecular modeling, synthesis, and biological, nutritional, and phytochemical evaluation of indole derivatives will be accepted.

Dr. Anna Caruso
Guest Editor

Manuscript Submission Information

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Keywords

  • indole derivatives
  • benzoindoles
  • carbazoles
  • pyranoindoles
  • staurosporines
  • heterocyclic compounds
  • medicinal chemistry
  • drug development
  • industrial applications

Published Papers (1 paper)

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Research

12 pages, 1668 KiB  
Article
Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages
by Simona Todisco, Vittoria Infantino, Anna Caruso, Anna Santarsiero, Paolo Convertini, Hussein El-Kashef, Federica Giuzio, Maria Stefania Sinicropi and Carmela Saturnino
Appl. Sci. 2024, 14(15), 6747; https://doi.org/10.3390/app14156747 - 2 Aug 2024
Viewed by 213
Abstract
Cyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation. PDE activity and expression are linked to many diseases including inflammatory diseases. In light of their specific [...] Read more.
Cyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation. PDE activity and expression are linked to many diseases including inflammatory diseases. In light of their specific biochemical properties, PDE inhibition has attracted the interest of several researrs In this context, PDE4 inhibition induces anti-inflammatory effects. Piclamilast and rolipram, well-known PDE4 inhibitors, are endowed with common side effects. The selective phosphodiesterase 4B (PDE4B) inhibitors could be a promising approach to overcome these side effects. In the present study, six potential PDE4B inhibitors have been investigated. Through this study, we identified three PDE4B inhibitors in human macrophages activated by lipopolysaccharide. Interestingly, two of them reduced reactive oxygen species production in pro-inflammatory macrophages. Full article
(This article belongs to the Special Issue Indole Derivatives as Tools in New Drug Development)
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