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Applications of Nanocarriers for Phytochemical Delivery

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (30 August 2024) | Viewed by 585

Special Issue Editor


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Guest Editor
The Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Interests: drug delivery; lipid nanoparticles; bioavailability; DSC; FTIR; dissolution; solubility; HPLC; separation; pharmaceutical analysis; LC–MS; proteomics; proteome
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Special Issue Information

Dear Colleagues,

In recent decades, nanotechnology has profoundly impacted the field of pharmaceutical sciences, mainly through the development of nanomedicine. This field has witnessed significant advancements in developing diverse nanocarriers tailored for drug delivery. Nanocarriers, including nanoemulsions, liposomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanoparticles, micelles, and inorganic nanoparticles, have garnered considerable attention due to their biodegradability, biocompatibility, and safety profile in the human body. These nanocarriers have demonstrated their efficacy in delivering a wide range of drugs, including small molecules, peptides, proteins, and genes, for various therapeutic applications. By enhancing solubility, stability, absorption, and bioavailability, nanocarriers offer a promising avenue for improving the overall therapeutic outcomes of drugs.

Phytochemicals have gained increasing attention for their potential health benefits. These bioactive substances possess various biological properties, including antioxidant, anti-inflammatory, anticancer, and immune-boosting activities. Various nanocarriers have been used to encapsulate these phytochemicals in an attempt to improve their solubility, stability, and bioavailability while minimizing adverse effects.

In this Special Issue, we welcome original research and reviews on topics including, but not limited to, the development of nanocarriers to encapsulate phytochemicals; the evaluation of phytochemical-loaded nanocarriers regarding drug transport, distribution, and bioavailability; the applications of phytochemical-loaded nanocarriers to treat various diseases in animal models; and comprehensive reviews of phytochemical delivery using various types of nanocarriers.

Dr. Van-An Duong
Guest Editor

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Keywords

  • pharmaceutical
  • phytochemicals
  • drug delivery
  • nanocarriers
  • phytochemical delivery
  • bioavailability

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Published Papers (1 paper)

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Research

23 pages, 1953 KiB  
Article
Microencapsulation of Blueberry (Vaccinium myrtillus L.) Extracts via Ionotropic Gelation: In Vitro Assessment of Bioavailability of Phenolic Compounds and Their Activity against Colon Cancer Cells
by Natalia Żurek, Michał Świeca, Agata Pawłowska and Ireneusz Tomasz Kapusta
Appl. Sci. 2024, 14(17), 7842; https://doi.org/10.3390/app14177842 - 4 Sep 2024
Viewed by 312
Abstract
The aim of the study was to design microcapsules with a core of blueberry fruit extracts (Vaccinium myrtillus L.) using the ionotropic gelation method and then assess the effect of the type of extracts used and the combination of polymers on the [...] Read more.
The aim of the study was to design microcapsules with a core of blueberry fruit extracts (Vaccinium myrtillus L.) using the ionotropic gelation method and then assess the effect of the type of extracts used and the combination of polymers on the profile of phenolic compounds, their in vitro bioavailability, stability during storage, as well as their antioxidant characteristics and cytotoxic activity against colon cancer cells while assessing biocompatibility against normal colon epithelial cells. Encapsulation efficiency (EE), ranging from 8.79 to 74.55%, significantly depended on the extract used and the type of carrier. It was shown that the addition of pectin (Pect) and whey protein isolate (WPI) to alginate (Alg) improved the efficiency of the encapsulation process. For this version of microcapsules, the highest antioxidant activity, phenolic compound content and their stability during storage were also demonstrated. The estimated content of phenolic compounds ranged from 0.48 to 40.07 mg/g, and the dominant compound was cyanidin 3-O-glucoside. In turn, the highest bioavailability of these compounds and the highest cytotoxic activity against cancer cells were characterized by microcapsules with Alg and WPI. Nevertheless, good biocompatibility with normal colon epithelial cells was demonstrated for all versions of microcapsules. The obtained data indicate that the tested variants of microcapsules protect the bioactive compounds of blueberry fruit extracts, which translates into maintaining their health-promoting properties. Full article
(This article belongs to the Special Issue Applications of Nanocarriers for Phytochemical Delivery)
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