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Synthesis, Application, and Biological Evaluation of Inorganic and Organic Compounds

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1347

Special Issue Editors


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Guest Editor
Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria
Interests: metal complexes; coordination compounds, experimental studies; structural characterization; biological properties; antibacterial activities; cytotoxicity; anticancer
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria
Interests: antimicrobials; food microbiology; PCR diagnostics; immobilized cells; probiotics; microbial transformations

Special Issue Information

Dear Colleagues,

Our society requires new innovations both to foster its own progress and to address specific challenges. In this regard, chemistry can contribute by discovering new compounds with biological activity. These new compounds can be chemically synthesized or extracted and purified from natural sources, and may hold great potential for use in the treatment of cancer, diabetes, cardiovascular diseases, and other pathologies, pest control in agriculture and veterinary medicine, or in the disinfection of equipment, spaces, or surfaces, among other applications. In this Special Issue, we invite studies that describe the initial synthesis, isolation, preparation, characterization, and biological activities of chemical compounds that could have future applications in biology, pharmacy, medicine, medicinal chemistry, veterinary science, dental medicine, agriculture, and public health.

This Special Issue, "Synthesis, Application, and Biological Evaluation of Inorganic and Organic Compounds", encourages a focus on the following topics:

  1. Synthesis: Methods and processes used to create inorganic compounds in a laboratory setting, including the development of novel synthesis techniques or improvements in existing ones.
  2. Application: The practical use of these inorganic and organic compounds across various fields such as medicine, agriculture, industry, or technology. It could cover their roles in catalysis, materials science, nanoparticles, environmental protection, and in medicine for diagnostic imaging or cancer treatment or medical healing.
  3. Biological Evaluation: The assessment of how these inorganic and organic compounds interact with biological systems, including their potential therapeutic effects, toxicity, or applications in healthcare, such as in drug development, diagnostics, or treatment of diseases.

This title refers to research exploring the creation of new inorganic and organic compounds, their uses in various applications, and their impacts or effectiveness in biological contexts.

Dr. Petja Marinova
Dr. Denica Blazheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic chemistry
  • organic chemistry
  • chemical compounds
  • synthesis
  • metal complexes
  • biological activity
  • medicinal chemistry
  • active compounds
  • biological applications
  • pharmaceutical biotechnology
  • drug discovery and development
  • pharmacology
  • anticancer research
  • cytotoxicity
  • apoptosis
  • antibacterial assays

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Published Papers (1 paper)

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Review

39 pages, 2406 KiB  
Review
A (Comprehensive) Review of the Application of Quantitative Structure–Activity Relationship (QSAR) in the Prediction of New Compounds with Anti-Breast Cancer Activity
by Boris Vasilev and Mariyana Atanasova
Appl. Sci. 2025, 15(3), 1206; https://doi.org/10.3390/app15031206 - 24 Jan 2025
Cited by 1 | Viewed by 1115
Abstract
Computational approaches applied in drug discovery have advanced significantly over the past few decades. These techniques are commonly grouped under the term “computer-aided drug design” (CADD) and are now considered one of the key pillars of pharmaceutical discovery pipelines in both academic and [...] Read more.
Computational approaches applied in drug discovery have advanced significantly over the past few decades. These techniques are commonly grouped under the term “computer-aided drug design” (CADD) and are now considered one of the key pillars of pharmaceutical discovery pipelines in both academic and industrial settings. In this work, we review Quantitative Structure–Activity Relationships (QSARs), one of the most used ligand-based drug design (LBDD) methods, with a focus on its application in the discovery and development of anti-breast cancer drugs. Critical steps in the QSAR methodology, essential for its correct application—but often overlooked, leading to insignificant or misleading models—are examined. Additionally, current anti-breast cancer treatment strategies were briefly overviewed, along with some targets for future treatments. The review covers QSAR studies from the past five years and includes a discussion of notable works that could serve as models for future applications of this interdisciplinary and complex method and that may help in feature drug design and development. Full article
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