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Photonics in BioMedical Progress
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Photonics in BioMedical Progress

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 13132

Special Issue Editor

Dr. Jinsik Kim

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Dongguk University, Goyang-si, Korea
Interests: MEMS based Biosensors with multi-functionalized microfluidic chips; optical and electrical biosensor such as Si-optoelectronics, colorimetric analysis with FRET (Fluorescent Resonance energy transfer) or FET with 2-D carbon materials. And the methods to enhance the performance of sensing with manipulations of biomolecules with optical and electrokinetic methods.

Special Issue Information

Dear Colleagues,

 The photonics which is a huge and important part in physics or electrical engineering. Indeed, photonics has brought about the rapid development of various telecommunication, including the LASER industry, biological and chemical sensing technologies. In addition, research in various fields related to source, amplification, modulation, detection, transmission and etc. is being conducted within the photonics. Convergence of the specific fields with biomedical engineering has the potential to bring about tremendous advances for overcoming barrier of conventional methods in biomedical engineering.
Therefore, this special issue is dedicated to compile a collection the novel approaches of research or review results from a broad category related to the application of biomedical engineering with Photonics. Since the main goal of present special issue is to introduce the demonstration of convergence between biomedical engineering and various technologies of photonics, the topics are appropriate to show the results of the utilization of photonics for various bio medical engineering related purposed such as treatment or diagnosis. And the techniques related to photonics are described below.

Dr. Jinsik Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Laser therapeutics,
  • Laser, Imaging sensor,
  • Colorimetric sensor,
  • Plasmonics,
  • Photo-acoustics,
  • Fiber optics,
  • Opto-electronics,
  • Optical modulations and others related to photonics

Published Papers (5 papers)

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Research

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7 pages, 1439 KiB  
Article
Broadband Passively Mode-Locked Fiber Laser with DNA Aqueous Solution as Saturable Absorber
by Mijin Kim, Jeong Je Kim, Sang Bae Lee, Dal-Young Kim, Kwanil Lee and Wonsuk Lee
Appl. Sci. 2021, 11(21), 9871; https://doi.org/10.3390/app11219871 - 22 Oct 2021
Cited by 7 | Viewed by 1661
Abstract
We demonstrate a passively mode-locked fiber laser using aqueous DNA solution as a saturable absorber (SA), with broadband pulse laser emission from 1 to 1.5 µm. The mode-locked laser with erbium-doped fiber as the gain material has a center wavelength of 1563 nm, [...] Read more.
We demonstrate a passively mode-locked fiber laser using aqueous DNA solution as a saturable absorber (SA), with broadband pulse laser emission from 1 to 1.5 µm. The mode-locked laser with erbium-doped fiber as the gain material has a center wavelength of 1563 nm, a 3 dB bandwidth of 3.9 nm, and a pulse width of 822 fs, whereas the laser with ytterbium-doped fiber as the gain material and an identical DNA aqueous SA has a center wavelength of 1037 nm, a 3 dB bandwidth of 5.04 nm, and a pulse width of 250 ps. The proposed laser, which is simple and cost effective to fabricate, exhibits excellent long-term stability as well as thermal stability during high-power operation. This mode-locked laser scheme with a liquid-phase DNA component has the potential to provide in-depth understanding of the optical nonlinearity and usefulness of DNA. Full article
(This article belongs to the Special Issue Photonics in BioMedical Progress)
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12 pages, 3183 KiB  
Article
Validation of Fucoxanthin from Microalgae Phaeodactylum tricornutum for the Detection of Amyloid Burden in Transgenic Mouse Models of Alzheimer’s Disease
by A-Hyeon Lee, Sung-Chul Hong, Inwook Park, Soljee Yoon, YoungSoo Kim, Jinsik Kim and Seung-Hoon Yang
Appl. Sci. 2021, 11(13), 5878; https://doi.org/10.3390/app11135878 - 24 Jun 2021
Cited by 3 | Viewed by 2424
Abstract
The visualization of misfolded Aβ peptides by using fluorescence chemical dyes is very important in Alzheimer’s disease (AD) diagnosis. Here, we describe the fluorescent substance, fucoxanthin, which detects Aβ aggregates in the brain of AD transgenic mouse models. We found that fucoxanthin from [...] Read more.
The visualization of misfolded Aβ peptides by using fluorescence chemical dyes is very important in Alzheimer’s disease (AD) diagnosis. Here, we describe the fluorescent substance, fucoxanthin, which detects Aβ aggregates in the brain of AD transgenic mouse models. We found that fucoxanthin from the microalgae Phaeodactylum tricornutum has fluorescent excitation and emission wavelengths without any interference for Aβ interaction. Thus, we applied it to monitor Aβ aggregation in AD transgenic mouse models. Aβ plaques were visualized using fucoxanthin in the brain tissue of APP/PS1 and 5×FAD mice by histological staining with different staining methods. By comparing fucoxanthin-positive and thioflavin S-positive stained regions in the brains, we found that they are colocalized and that fucoxanthin can detect Aβ aggregates. Our finding suggests that fucoxanthin from P. tricornutum can be a new Aβ fluorescent imaging reagent in AD diagnosis. Full article
(This article belongs to the Special Issue Photonics in BioMedical Progress)
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11 pages, 4070 KiB  
Article
Fabrication of Lensed Optical Fibers for Biosensing Probes Using CO2 and Femtosecond Lasers
by Ki-Dong Lim, Hun-Kook Choi, Ik-Bu Sohn, Byeong-Ha Lee and Jin-Tae Kim
Appl. Sci. 2021, 11(9), 3738; https://doi.org/10.3390/app11093738 - 21 Apr 2021
Cited by 6 | Viewed by 2519
Abstract
We propose a new method for precisely fabricating a lensed fiber with a desired focal length by first cleaving a coreless silica fiber using an ultrafast femtosecond laser without thermal effects and subsequently shaping the radius of curvature at the optical-fiber end using [...] Read more.
We propose a new method for precisely fabricating a lensed fiber with a desired focal length by first cleaving a coreless silica fiber using an ultrafast femtosecond laser without thermal effects and subsequently shaping the radius of curvature at the optical-fiber end using a CO2 laser. The precisely cleaved segment of the coreless silica fiber obtained with the femtosecond laser is attached to a long single-mode fiber. The beam-exposure time and laser power of the CO2 laser are adjusted to melt the coreless-fiber end to yield a uniform, consistent, and precise radius of curvature, thereby realizing a lensed optical fiber. The precision of the radius of curvature in this case is greater than those obtained with the conventional arc discharge method with thermal treatment requiring fairly complex processes and yielding relatively low fabrication accuracy. In our study, we observe a difference between the measured and calculated focal lengths of the fabricated lens, possibly because the exact value of the mode field diameter is uncertain. On the other hand, the beam size measured using the knife-edge method matches closely with the theoretical size. Our findings confirm the feasibility of fabricating lensed optical fibers for fiber-based biosensing using CO2 and femtosecond lasers. Full article
(This article belongs to the Special Issue Photonics in BioMedical Progress)
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10 pages, 2855 KiB  
Article
Enhancement of Optical Chirality Using Metasurfaces for Enantiomer-Selective Molecular Sensing
by Sangtae Jeon and Soo Jin Kim
Appl. Sci. 2021, 11(7), 2989; https://doi.org/10.3390/app11072989 - 26 Mar 2021
Cited by 4 | Viewed by 3122
Abstract
Circular dichroism (CD) is a physical property observed in chiral molecules by inducing the difference of absorption between left- and right-handed circularly polarized light (CPL). Circular dichroism spectroscopy is widely used in the field of chemistry and biology to distinguish the enantiomers, which [...] Read more.
Circular dichroism (CD) is a physical property observed in chiral molecules by inducing the difference of absorption between left- and right-handed circularly polarized light (CPL). Circular dichroism spectroscopy is widely used in the field of chemistry and biology to distinguish the enantiomers, which typically show either positive or severe side effects in biological applications depending on the molecular structures’ chirality. To effectively detect the chirality of molecules, diverse designs of nanostructured platforms are proposed based on optical resonances that can enhance the optical chirality and amplify the signal of circular dichroism. However, the underlying physics between the optical chirality and the resonance in a nanostructure is largely unexplored, and thus designing rules for optimal chiral detection is still elusive. Here, we carry out an in-depth analysis of chiral enhancement (C enhancement) in nanostructured surfaces to find the relationship between optical resonances and chirality. Based on the relations, we optimize the nanostructured metasurface to induce effective chiral detection of enantiomers for diverse conditions of molecule distribution. We believe that the proposed designing rules and physics pave the important pathway to enhance the optical chirality for effective circular dichroism spectroscopy. Full article
(This article belongs to the Special Issue Photonics in BioMedical Progress)
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Review

Jump to: Research

18 pages, 2475 KiB  
Review
Optical Modalities for Research, Diagnosis, and Treatment of Stroke and the Consequent Brain Injuries
by Sung Suk Oh, Yoonhee Kim, Yoon Bum Lee, Seung Kuk Bae, Jun Sik Kim, Sang-hyun An and Jong-ryul Choi
Appl. Sci. 2022, 12(4), 1891; https://doi.org/10.3390/app12041891 (registering DOI) - 11 Feb 2022
Cited by 4 | Viewed by 2592
Abstract
Stroke is the second most common cause of death and third most common cause of disability worldwide. Therefore, it is an important disease from a medical standpoint. For this reason, various studies have developed diagnostic and therapeutic techniques for stroke. Among them, developments [...] Read more.
Stroke is the second most common cause of death and third most common cause of disability worldwide. Therefore, it is an important disease from a medical standpoint. For this reason, various studies have developed diagnostic and therapeutic techniques for stroke. Among them, developments and applications of optical modalities are being extensively studied. In this article, we explored three important optical modalities for research, diagnostic, and therapeutics for stroke and the brain injuries related to it: (1) photochemical thrombosis to investigate stroke animal models; (2) optical imaging techniques for in vivo preclinical studies on stroke; and (3) optical neurostimulation based therapy for stroke. We believe that an exploration and an analysis of previous studies will help us proceed from research to clinical applications of optical modalities for research, diagnosis, and treatment of stroke. Full article
(This article belongs to the Special Issue Photonics in BioMedical Progress)
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