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Bioengineering
Special Issues
Advances in Tissue Engineering and Regenerative Medicine
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Advances in Tissue Engineering and Regenerative Medicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 19545

Special Issue Editors

Dr. Andrea Paola Rodríguez

E-Mail Website
Guest Editor
Laboratorio de Medios e Interfases, Departamento de Bioingeniería, Facultad de Ciencias Exactas y Tecnología, Universidad Nacional de Tucumán, Av. Independencia 1800, Tucumán CP4000, Argentina
Interests: tissue engineering; regenerative medicine and nanotechnology engineering
Prof. Dr. Élida B. Hermida

E-Mail Website
Co-Guest Editor
School of Science and Technology, National University of San Martín (UNSAM), Av. 25 de mayo 1147, B1650HMK, San Martín, Buenos Aires, Argentina
Interests: processing, structural and thermo-mechanical characterization of polymers and composites; biomaterials and scaffolds for tissue engineering and regenerative medicine; environmental impact of plastics; plastics degradation in different environments
Dr. Leandro N. Monsalve

E-Mail Website
Co-Guest Editor
Advanced Material Center, Instituto Nacional de Tecnología Industrial, San Martín, Buenos Aires, Argentina
Interests: carbon nanotubes; polymer composites

Special Issue Information

Dear Colleagues,

We kindly invite and encourage the global research community to send their contributions on tissue engineering and regenerative medicine to this Special Issue.

Tissue engineering and regenerative medicine are major research topics among scientists from all around the world nowadays. They are a multidisciplinary field that applies principles from medicine, materials science, engineering, and molecular biology. Their main objective is the application of engineering techniques for the fabrication of biological substitutes with the ability of totally or partially regenerating impaired organs or tissues. Tissue engineering was initiated in the 1970s and has experienced major breakthroughs since then. However, the design and fabrication of cutting-edge porous scaffolds capable of promoting tissue regeneration and complete functional recovery in every tissue is still a challenge.

This Special Issue of Bioengineering on tissue engineering and regenerative medicine will allow experts from all around the world to gather and show the great potential of research and technological innovation in this field.

Dr. Andrea Paola Rodríguez
Prof. Dr. Élida B. Hermida
Dr. Leandro N. Monsalve
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regenerative medicine
  • biodegradable materials, scaffold, cellular therapy

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Research

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17 pages, 5716 KiB  
Article
An In Vivo Rat Study of Bioresorbable Mg-2Zn-2Ga Alloy Implants
by Alexey Drobyshev, Zaira Gurganchova, Nikolay Redko, Alexander Komissarov, Viacheslav Bazhenov, Eugene S. Statnik, Iuliia A. Sadykova, Eugeny Sviridov, Alexey I. Salimon, Alexander M. Korsunsky, Oleg Zayratyants, Denis Ushmarov and Oleg Yanushevich
Bioengineering 2023, 10(2), 273; https://doi.org/10.3390/bioengineering10020273 - 20 Feb 2023
Cited by 2 | Viewed by 2247
Abstract
In the present study, pins made from the novel Mg-2Zn-2Ga alloy were installed within the femoral bones of six Wistar rats. The level of bioresorption was assessed after 1, 3, and 6 months by radiography, histology, SEM, and EDX. Significant bioresorption was evident [...] Read more.
In the present study, pins made from the novel Mg-2Zn-2Ga alloy were installed within the femoral bones of six Wistar rats. The level of bioresorption was assessed after 1, 3, and 6 months by radiography, histology, SEM, and EDX. Significant bioresorption was evident after 3 months, and complete dissolution of the pins occurred at 6 months after the installation. No pronounced gas cavities could be found at the pin installation sites throughout the postoperative period. The animals’ blood parameters showed no signs of inflammation or toxication. These findings are sufficiently encouraging to motivate further research to broaden the experimental coverage to increase the number of observed animals and to conduct tests involving other, larger animals. Full article
(This article belongs to the Special Issue Advances in Tissue Engineering and Regenerative Medicine)
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13 pages, 2764 KiB  
Article
A Comparative Study Using Fluorescent Confocal Microscopy and Flow Cytometry to Evaluate Chondrocyte Viability in Human Osteochondral Allografts
by Patricia López-Chicón, Tatiana Riba-Tietz, Oscar Fariñas, Pablo-Eduardo Gelber, Ricardo-Pedro Casaroli-Marano and Anna Vilarrodona
Bioengineering 2022, 9(10), 515; https://doi.org/10.3390/bioengineering9100515 - 29 Sep 2022
Cited by 1 | Viewed by 2418
Abstract
The preservation conditions of fresh osteochondral allografts for clinical applications are critical due their objective: to transplant mature hyaline cartilage containing viable chondrocytes, maintaining their metabolic activity and also preserving the structural and functional characteristics of the extracellular matrix. The aim of the [...] Read more.
The preservation conditions of fresh osteochondral allografts for clinical applications are critical due their objective: to transplant mature hyaline cartilage containing viable chondrocytes, maintaining their metabolic activity and also preserving the structural and functional characteristics of the extracellular matrix. The aim of the present study was to compare fluorescence confocal microscopy and flow cytometry techniques to evaluate the viability of the chondrocytes present in the osteochondral tissue, in order to determine their effectiveness and thus ensure reproducibility and robustness of the analysis. To this end, osteochondral allografts from human cadaveric donors were preserved at 4 °C for 3 weeks in a preservation medium supplemented with antibiotic and antifungal agents. Cell viability of chondrocytes was determined by monitoring the cartilage for 3 weeks of preservation by confocal fluorescence microscopy and flow cytometry, obtaining cell viabilities of 83.7 ± 2.6% and 55.8 ± 7.8% for week three, respectively. The confocal fluorescence microscopy approach is more advantageous and accurate, as it correlates better with actual cell viability values for monitoring osteochondral graft preservation, detecting only the cells that died a natural death associated with the preservation method. Full article
(This article belongs to the Special Issue Advances in Tissue Engineering and Regenerative Medicine)
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Review

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18 pages, 3260 KiB  
Review
Recent Advances in Apical Periodontitis Treatment: A Narrative Review
by Zulema Arias, Mohammed Zahedul Islam Nizami, Xiaoting Chen, Xinyi Chai, Bin Xu, Canyan Kuang, Kazuhiro Omori and Shogo Takashiba
Bioengineering 2023, 10(4), 488; https://doi.org/10.3390/bioengineering10040488 - 19 Apr 2023
Cited by 5 | Viewed by 6703
Abstract
Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. However, clinical failure has been reported with this [...] Read more.
Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. However, clinical failure has been reported with this approach; thus, alternative procedures are required. This review highlights recent literature regarding advanced approaches for the treatment of apical periodontitis. Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, have been tested to increase the success rate of treatment for apical periodontitis. Some of these approaches remain in the in vivo phase of research, while others have just entered the translational research phase to validate clinical application. However, a detailed understanding of the molecular mechanisms that occur during development of the immunoinflammatory reaction in apical periodontitis remains unclear. The aim of this review was to summarize advanced approaches for the treatment of apical periodontitis. Further research can confirm the potential of these alternative nonsurgical endodontic treatment approaches. Full article
(This article belongs to the Special Issue Advances in Tissue Engineering and Regenerative Medicine)
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38 pages, 7767 KiB  
Review
Polymeric Materials, Advances and Applications in Tissue Engineering: A Review
by María Cecilia Socci, Gabriela Rodríguez, Emilia Oliva, Shigeko Fushimi, Kiyofumi Takabatake, Hitoshi Nagatsuka, Carmelo José Felice and Andrea Paola Rodríguez
Bioengineering 2023, 10(2), 218; https://doi.org/10.3390/bioengineering10020218 - 6 Feb 2023
Cited by 39 | Viewed by 7085
Abstract
Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in combination with biological and engineering sciences. In recent years, an increase in the demand for therapeutic strategies for improving quality of life has necessitated innovative approaches to designing intelligent biomaterials aimed [...] Read more.
Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in combination with biological and engineering sciences. In recent years, an increase in the demand for therapeutic strategies for improving quality of life has necessitated innovative approaches to designing intelligent biomaterials aimed at the regeneration of tissues and organs. Polymeric porous scaffolds play a critical role in TE strategies for providing a favorable environment for tissue restoration and establishing the interaction of the biomaterial with cells and inducing substances. This article reviewed the various polymeric scaffold materials and their production techniques, as well as the basic elements and principles of TE. Several interesting strategies in eight main TE application areas of epithelial, bone, uterine, vascular, nerve, cartilaginous, cardiac, and urinary tissue were included with the aim of learning about current approaches in TE. Different polymer-based medical devices approved for use in clinical trials and a wide variety of polymeric biomaterials are currently available as commercial products. However, there still are obstacles that limit the clinical translation of TE implants for use wide in humans, and much research work is still needed in the field of regenerative medicine. Full article
(This article belongs to the Special Issue Advances in Tissue Engineering and Regenerative Medicine)
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