2025 March - 114 articles
The construction of artificial microorganisms often relies on the transfer of genomes from donor to acceptor cells. This synthetic biology approach has been considerably fostered by the J. Craig Venter Institute but apparently depends on the use of m...
The increasing global demand for natural substances such as the sesquiterpene α-humulene makes optimizing microbial production essential. A production process using the versatile host Cupriavidus necator has been recently improved by adjusting...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, with immunotherapy being a first-line treatment at the advanced stage and beyond. Hypoxia plays a critical role in tumor progression and resistance to therapy. This study dev...
The aim of this study was to predict Bruch’s membrane opening-minimum rim Width (BMO-MRW), a relatively new parameter using conventional optical coherence tomography (OCT) parameter, using retinal nerve fibre layer (RNFL) thickness and visual f...
Over the last several decades, computational biomechanics has been intensively investigated as part of the study of human body systems (musculoskeletal, cardiovascular, digestive, etc [...]
Intra-experimental factor setting shifts in intensified design of experiments (iDoE) enhance understanding of bioproduction processes by capturing their dynamics and are thus essential to fulfill quality by design (QbD) ambitions. Determining the inf...
Cranial sutures play critical roles in load distribution and neuroprotection, with their biomechanical performance intimately linked to morphological complexity. The purpose of this study was to investigate the effect of different morphologies of cra...
Background: Hallux limitus (HL) is a condition marked by the restricted dorsiflexion of the first metatarsophalangeal joint, causing pain and functional limitations, especially during the propulsive phase of walking. This restriction affects the gait...
The purpose of this paper is to provide researchers with a description of a data library representing human interaction with medium- to large-sized objects in everyday life. The library includes motion capture data characterizing human and object mot...
Scaffolds are critical in regenerative medicine, particularly in bone tissue engineering, where they mimic the extracellular matrix to support tissue regeneration. Scaffold efficacy depends on precise control of 3D printing parameters, which determin...
Pulse oximetry is essential for monitoring arterial oxygen saturation (
The analysis of human gait is a cornerstone in diagnosing and monitoring a variety of neuromuscular and orthopedic conditions. Recent technological advancements have paved the way for innovative methodologies that combine multimodal neuroimaging and...
Proteins are essential for all living organisms, playing key roles in biochemical reactions, structural support, signal transduction, and gene regulation. Their importance in biomedical research is highlighted by their role as drug targets in various...
Lung ultrasound (LUS) is a non-invasive bedside imaging technique for diagnosing pulmonary conditions, especially in critical care settings. A-lines and B-lines are important features in LUS images that help to assess lung health and identify changes...
Electroencephalography (EEG)-basedpersonal identification has gained significant attention, but fluctuations in emotional states often affect model accuracy. Previous studies suggest that multisensory stimuli, such as video and olfactory cues, can en...
The healthcare industry seeks to integrate AI into clinical applications, yet understanding AI decision making remains a challenge for healthcare practitioners as these systems often function as black boxes. Our work benchmarks the Pattern Discovery...
The gastrointestinal (GI) tract, an integral part of the digestive system, absorbs nutrients from ingested food, starting from the mouth to the anus. GI tract cancer significantly impacts global health, necessitating precise treatment methods. Radiat...
Following tooth extraction, the bone structure is prone to atrophic changes. Alveolar ridge resorption can compromise subsequent implant treatment not only at the extraction site itself but also by affecting the bone support of adjacent teeth. Variou...
Background: Surgical indication of ascending thoracic aortic aneurysms (ATAA) is generally performed in prevention. Guidelines use aortic diameter as a predictor of rupture and dissection; however, this single parameter alone has a limited value in p...
Giant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare...
The primary challenges in the tissue engineering of small-diameter artificial blood vessels include inadequate mechanical properties and insufficient anticoagulation capabilities. To address these challenges, urea-pyrimidone (Upy)-based polyurethane...
Capillary electrophoresis based on laser-induced fluorescence (CE-LIF) plays an important role in the analysis of nucleic acids. However, the commercial CE-LIF is not only quite expensive but also inflexible, thus hindering its widespread use in the...
The COVID-19 pandemic has highlighted the significant infection risks posed by aerosol generating procedures (AGPs). We developed a hood that covers the patient’s respiratory area, incorporating a negative pressure system to contain aerosols. T...
After tooth extraction, resorptive changes in extraction sockets and the adjacent alveolar ridge can affect subsequent tooth replacement and implantation. Several surgical concepts, including the application of autologous blood concentrate platelet-r...
Protecting people at work and at leisure, and improving their quality of life, is one of the major challenges faced in this century [...]
This study aimed to quantitatively assess trunk and cervical non-neutral postures assumed by surgeons during the performance of routine open procedures. Indeed, musculoskeletal disorders are frequently reported by surgeons, especially at the head and...
Bacterial infections remain a global healthcare challenge, requiring precise diagnostic modalities to guide therapeutic interventions. Current molecular imaging agents predominantly detect nonspecific hemodynamic alterations and lack pathogen-specifi...
Hallux limitus pathology is defined as a limitation of the dorsiflexion movement of the first toe without degenerative involvement of the first metatarsophalangeal joint, which produces pain and generates functional impairment, especially in the prop...
Purpose: We aimed to develop a simple nomogram and online calculator that can identify the optimal subpopulation of pediatric acute myeloid leukemia (AML) patients who would benefit most from gemtuzumab ozogamicin (GO) therapy. Methods: Within the fr...
Because of their nature, biomarkers for neuropsychiatric diseases were out of the reach of medical diagnostic technology until the past few decades. In recent years, the confluence of greater, affordable computer power with the need for more efficien...
Running-induced fatigue affects several biomechanical parameters, and yet few studies are focused on the acceleration spikes’ asymmetries. This study aimed to evaluate the effects of a 30 min run on lower limbs spikes’ asymmetries. Eighte...
Background: We address the application of artificial intelligence (AI) techniques in thyroid cytopathology, specifically for diagnosing papillary thyroid carcinoma (PTC), the most common type of thyroid cancer. Methods: Our research introduces deep l...
Strength training machines incorporating advanced electro-mechanical technologies can produce hybrid resistances with variable inertia, such as a resistance that progressively changes from gravitational (inertial) to pneumatic (non-inertial) across t...
Objective: The cancer death rate has accelerated at an alarming rate, making accurate diagnosis at the primary stages crucial to enhance prognosis. This has deepened the issue of cancer mortality, which is already at an exponential scale. It has been...
Intelligent heart sound diagnosis based on Convolutional Neural Networks (CNN) has been attracting increasing attention due to its accuracy and efficiency, which have been improved by recent studies. However, the performance of CNN models, heavily in...
Current routine diagnostic procedures for back pain mainly focus on static spinal analyses. Dynamic Surface Topography (DST) is an easy-to-use, radiation-free addition, allowing spine analyses under dynamic conditions. Until now, it is unclear if thi...
The integration of artificial intelligence (AI) into ultrasound medicine has revolutionized medical imaging, enhancing diagnostic accuracy and clinical workflows. This review focuses on the applications, challenges, and future directions of AI techno...
Neurological diseases leading to motor deficits constitute significant challenges to healthcare systems. Despite technological advancements in data acquisition, sensor development, data processing, and virtual reality (VR), a suitable framework for p...
Accurate sleep staging is critical for assessing sleep quality and diagnosing sleep disorders. Recent research efforts on automated sleep staging have focused on complex deep learning architectures that have achieved modest improvements in classifica...
Coronary heart disease, a leading global cause of mortality, has witnessed significant advancement through robotic coronary artery bypass grafting (CABG), with the internal mammary artery (IMA) emerging as the preferred “golden conduit” f...
Microalgae are valuable sources of bioactive compounds. However, their production requires strategies to enhance metabolic responses. This study explores how Chlorella vulgaris responds to different salinity conditions using a two-stage cultivation s...
The core characteristics of autism spectrum disorder (ASD) are atypical neurodevelopmental disorders. Transcranial direct current stimulation (tDCS), as a non-invasive brain stimulation technique, has been applied in the treatment of various neurodev...
The rising prevalence of skin lesions places a heavy burden on global health resources and necessitates an early and precise diagnosis for successful treatment. The diagnostic potential of recent multi-modal skin lesion detection algorithms is limite...
Hands-free visual assistive devices that consider the safety of the visually impaired have been researched, but many of them interfere with other senses, such as hearing. Therefore, phosphenes have been researched as a method of presenting visual inf...
Monitoring the training load is crucial in sports science research, as it provides scientific evidence for assessing training effects, optimizing athletic performance, and preventing overtraining by quantifying both external and internal loads. Altho...
Age-related macular degeneration (AMD), a progressive neurodegenerative disorder affecting the central retina, is pathologically defined by the irreversible degeneration of photoreceptors and retinal pigment epithelium (RPE), coupled with extracellul...
Patients undergoing aortic valve repair or replacement with associated alterations in stiffness characteristics often develop abnormalities in the aortic sinus vortex, which may impact aortic valve function. The correlation between altered aortic sin...
Shape Memory Alloys (SMAs) have emerged as a promising actuation technology for wearable rehabilitation robots due to their unique properties, including the shape memory effect, high actuation stress, pseudoelasticity, and three-dimensional actuation...
Polyp segmentation is crucial for early colorectal cancer detection, but accurately delineating polyps is challenging due to their variations in size, shape, and texture and low contrast with surrounding tissues. Existing methods often rely solely on...
Skin diseases are listed among the most frequently encountered diseases. Skin diseases such as eczema, melanoma, and others necessitate early diagnosis to avoid further complications. This study aims to enhance the diagnosis of skin disease by utiliz...
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