Repair and Regeneration of Skeletal Muscle

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Developmental and Reproductive Biology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2116

Special Issue Editor


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Guest Editor
1. Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Northeast Agricultural University, Harbin 150030, China
2. Laboratory of Cell and Developmental Biology, Northeast Agricultural University, Harbin 150030, China
Interests: muscle post-injury regeneration and repair; muscle nutrition and disease

Special Issue Information

Dear Colleagues,

Skeletal muscle, as one of the most important organs in the human body, plays a variety of important physiological functions in human beings, such as movement and metabolism. Aging, chronic diseases, drug stimulation, physical trauma, and other factors usually cause skeletal muscle sarcopenia, atrophy, or injury. Severe skeletal muscle damage often impairs the function of skeletal-muscle-specific stem cells, muscle satellite cells (MuSCs), making it difficult to repair skeletal muscle injury and seriously affecting normal physiological activities and quality of life. This has always been a hot topic in the fields of life science and regenerative medicine. Therefore, this Special Issue welcomes submissions of research conducted from a wide range of angles, from studies elucidating the roles and developmental mechanisms of MuSCs to those exploring novel methods and strategies such as drug intervention, stem cell therapy, tissue engineering technology, and so on, for effectively promoting skeletal muscle regeneration and repair. We hope that our research will help to promote the regeneration and repair of skeletal muscle injury, maintain the homeostasis of skeletal muscle tissue, and restore the health of skeletal muscle.

Prof. Dr. Huili Tong
Guest Editor

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Keywords

  • skeletal muscle
  • sarcopenia
  • atrophy
  • muscle satellite cells
  • regeneration and repair

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Published Papers (1 paper)

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Review

26 pages, 1328 KiB  
Review
From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders
by Elisa Duranti and Chiara Villa
Biology 2024, 13(9), 719; https://doi.org/10.3390/biology13090719 - 12 Sep 2024
Viewed by 1816
Abstract
Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD), primarily affect the central nervous system, leading to progressive neuronal loss and motor and cognitive dysfunction. However, recent studies have revealed that muscle tissue also plays a significant [...] Read more.
Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD), primarily affect the central nervous system, leading to progressive neuronal loss and motor and cognitive dysfunction. However, recent studies have revealed that muscle tissue also plays a significant role in these diseases. ALS is characterized by severe muscle wasting as a result of motor neuron degeneration, as well as alterations in gene expression, protein aggregation, and oxidative stress. Muscle atrophy and mitochondrial dysfunction are also observed in AD, which may exacerbate cognitive decline due to systemic metabolic dysregulation. PD patients exhibit muscle fiber atrophy, altered muscle composition, and α-synuclein aggregation within muscle cells, contributing to motor symptoms and disease progression. Systemic inflammation and impaired protein degradation pathways are common among these disorders, highlighting muscle tissue as a key player in disease progression. Understanding these muscle-related changes offers potential therapeutic avenues, such as targeting mitochondrial function, reducing inflammation, and promoting muscle regeneration with exercise and pharmacological interventions. This review emphasizes the importance of considering an integrative approach to neurodegenerative disease research, considering both central and peripheral pathological mechanisms, in order to develop more effective treatments and improve patient outcomes. Full article
(This article belongs to the Special Issue Repair and Regeneration of Skeletal Muscle)
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