Approaches for the Reconstruction of Protein Families’ and Superfamilies’ Evolution with Consequences for De Novo Protein Design 2.0
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 8866
Special Issue Editor
2. Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190 Wien, Austria
Interests: molecular phylogeny analysis; peroxidases; catalases; phylogenetic analysis; reactive oxygen species; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
I invite you to submit your original research work and reviews for the new issue of Biology (MDPI) with the title “Approaches for the Reconstruction of Protein Families’ and Superfamilies’ Evolution with Consequences for De Novo Protein Design 2.0”. The focus of this updated issue topic is obtaining a comprehensive overview on various important achievements in the analysis of molecular evolution and structure–function relationships in diverse protein families and superfamilies originating from divergent organisms (both prokaryotic and eukaryotic). It will surely be interesting to compare convergent and divergent pathways of molecular evolution for distinct proteins based on experimental data and resolved 3D structures and to find out certain unifying rules. Additionally, the search for archetypal subfamilies and the sequences and structures of reconstructed ancestors is of great importance. This topic has already frequently been present in the literature of the last two decades, but the purpose of this Special Issue is to bring together current research outcomes from various experts and teams in one place to obtain a rather comprehensive overview of the capacity and possibilities of convergent and divergent modes of evolution within various protein folds for future perspectives of a targeted approach for de novo protein design.
Dr. Marcel Zamocky
Guest Editor
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Keywords
- protein family evolution
- protein superfamily
- convergent evolution
- divergent evolution
- molecular phylogeny
- horizontal gene transfer
- structure–function relationship
- de novo protein design
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