Biological Advances in Pregnancy Complications

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Developmental and Reproductive Biology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 914

Special Issue Editors


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Guest Editor
Department of Obstetrics, Gynecology & Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Interests: preeclampsia; gestational diabetes; infections; preterm labor; depression & anxiety; pregnancy loss/miscarriage; stillbirth

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Guest Editor
Department of Obstetrics, Gynecology & Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Interests: 3D ultrasound; 4D ultrasound; genetic amniocentesis; genetic screening; gynecologic ultrasound; high risk pregnancy; maternal fetal medicine; nuchal translucency measurement; prenatal diagnosis

Special Issue Information

Dear Colleagues,

Placenta-mediated complications result in significant short- and long-term maternal and fetal/neonatal morbidity and mortality. Preterm birth, hypertensive disorders of pregnancy, fetal growth restriction, abruption, and fetal loss comprise the collection of complications, collectively termed placenta-mediated complications. Obesity, gestational and pre-gestational diabetes, zoonotic diseases, and heat stress are increasingly prevalent worldwide. We are interested in the impact of combined exposures and their effects on both mothers and fetuses/neonates in the short and long term. Maternal pregnancy complications include metabolic syndrome or its components and other non-cardiovascular complications. For neonates, adverse outcomes include breathing, heart, brain, digestive, blood, and immune system problems and developmental delays in the babies. However, the biology aspect of these pregnancy complications and childbirth issues have not been studied well thus far. Thus, we plan to launch a Special Issue dealing with these aspects, which we believe will be helpful for both basic and clinical researchers to understand pregnancy complications better.

We are pleased to invite you and your colleagues to submit your work to this Special Issue, "Biological Advances in Pregnancy Complications." We welcome original articles, reviews, and potentially relevant communications. 

We look forward to receiving your contributions.

Dr. Arumugam R. Jayakumar
Prof. Dr. Michael J. Paidas
Guest Editors

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Keywords

  • preeclampsia
  • gestational diabetes
  • preterm birth
  • placental biology
  • fetal growth restriction
  • hypertensive disorders of pregnancy
  • maternal-fetal medicine
  • pregnancy-associated infections
  • immunological adaptations in pregnancy
  • epigenetics of pregnancy complications

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Published Papers (1 paper)

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Research

11 pages, 1333 KiB  
Article
Polymorphism of Folate Metabolism Genes among Ethnic Kazakh Women with Preeclampsia in Kazakhstan: A Descriptive Study
by Lyazzat Kaldygulova, Sauran Yerdessov, Talshyn Ukybassova, Yevgeniy Kim, Dinmukhamed Ayaganov and Andrey Gaiday
Biology 2024, 13(9), 648; https://doi.org/10.3390/biology13090648 - 23 Aug 2024
Cited by 1 | Viewed by 699
Abstract
Introduction: Preeclampsia is a severe multifactorial complication of pregnancy. Studies found associations between folate metabolism genes’ polymorphisms and preeclampsia. However, investigations in this field are limited among Asian populations. Thus, the study’s aim was to evaluate the prevalence of methionine synthase (MTR [...] Read more.
Introduction: Preeclampsia is a severe multifactorial complication of pregnancy. Studies found associations between folate metabolism genes’ polymorphisms and preeclampsia. However, investigations in this field are limited among Asian populations. Thus, the study’s aim was to evaluate the prevalence of methionine synthase (MTR), methionine synthase reductase (MTRR), and methylenetetrahydrofolate reductase (MTHFR) genes’ polymorphisms among ethnic Kazakh women with preeclampsia. Methods: This was a retrospective study involving 4246 patients’ data for the period of 2018–2022. Identification of MTR, MTRR, and MTHFR genes’ polymorphism was performed via PR-PCR. Peripheral blood samples were obtained for the analyses. In total, 4246 patients’ data of Kazakh ethnicity with preeclampsia at >20 weeks gestational age who had undergone an investigation to identify polymorphisms of the folate metabolism pathway genes for the period of 5 years were included in this study. Results: The most common and prevalent mutation was the MTRR A66G polymorphism: 24.5% of all tested patients with preeclampsia had the MTRR A66G polymorphism. It was highest among the 35–39 age group participants. The second most prevalent was the MTHFR C677T polymorphism: 9% of women with preeclampsia had the MTHFR C677T mutation. It was highest among women aged 30–34. There was a rare association of the MTR A2756G mutation with preeclampsia among the study participants. Conclusions: The identified levels of MTRR A66G and MTHFR C677T polymorphisms among the study participants suggest the importance of evaluating MTRR and MTHFR polymorphisms in women with preeclampsia. The role of the MTR A2756G polymorphism in the development of preeclampsia needs to be further investigated. Full article
(This article belongs to the Special Issue Biological Advances in Pregnancy Complications)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Dear Colleagues,

Placenta-mediated complications result in significant short- and long-term maternal and fetal/neonatal morbidity and mortality, including preterm birth, hypertensive disorders of pregnancy, fetal growth restriction, abruption, and fetal loss. Obesity, gestational and pre-gestational diabetes, zoonotic diseases, and heat stress are increasingly prevalent worldwide. We are interested in the impact of combined exposures on mothers and babies in the short and long term. Maternal complications include metabolic syndrome and non-cardiovascular issues, while neonates may experience various health problems and developmental delays. However, the biological aspects of these complications have not been well studied. To address this gap, we plan to launch a Special Issue focusing on these topics, beneficial for basic and clinical researchers.

We invite you and your colleagues to submit contributions to the Special Issue, "Biological Advances in Pregnancy Complications." We welcome original articles, reviews, and relevant communications for consideration. Your insights will enhance our understanding of pregnancy complications.

We look forward to your valuable contributions.

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