Cell-free DNA in Cancer Diagnostics: Current Advances
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 4027
Special Issue Editors
Interests: molecular biology; human physiology; metabolism; physiology markers; oncology; cancer biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The presence of cell-free nucleic acids in the plasma of healthy individuals was first reported in 1948. Since then, elevated levels of cfDNA have been found in various physiological and pathological conditions. An important research milestone in the molecular application of cell-free DNA as a marker, was the development of dedicated extraction kits and more sensitive detection instruments based on polymerase chain reaction such as quantitative PCR (qPCR), droplet digital PCR (ddPCR), or next-generation sequencing (NGS). Thanks to these developments, the diagnostic and therapeutic landscape of personalized medicine in cancer diagnostics has expanded rapidly. The instruments were able to detect even a small percentage of cell-free tumor DNA (ctDNA) with specific mutations. The advancement holds great promise to improve cancer treatment management, especially in the advanced stages of the disease and metastasis. Minimally invasive liquid biopsy belongs to the extensively studied issues of future cancer diagnostics.
In this Special Issue, we would like to provide a general idea of the advances of potential prognostic and diagnostic significance of cell-free DNA. On behalf of Biology, we cordially invite you to contribute an article to this project.
Dr. Robert Stawski
Dr. Ewelina Perdas
Guest Editors
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Keywords
- cell-free DNA
- ct DNA
- liquid biopsy
- diagnostics
- oncology
- cancer
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