Oxidative Stress in Neurodegenerative Diseases
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3038
Special Issue Editor
Interests: physical activity; neurodegeneration; microbiome; cardiovascular disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The aim of the present Special Issue is to investigate the crucial relationship between oxidative stress and neurodegenerative disorders. It is well known that the brain usually needs a large amount of oxygen to carry out its functions. Free radicals, oxygen and nitrogen species, are produced by several pathways that involve mitochondria, neurotransmitters, and redox active transition metals. In addition, neuronal cells have a high content of polyunsaturated fatty acids (PUFAs) in their membranes and poor antioxidant defenses, which make the brain vulnerable to free radicals. In fact, the resulting redox imbalance causes PUFA peroxidation and protein oxidation, altering their structure and function. Oxidative stress is also responsible for abnormalities affecting the autophagy mechanism, causing the accumulation of intracellular and extracellular bodies, containing misfolded proteins related to neuroinflammation and neurodegenerative diseases.
This Special Issue aims to collect original research and review articles in order to understand the physiological, metabolic, and cellular mechanisms that characterize the interaction between the oxidative stress and neurodegenerative disorders.
Potential topics include but are not limited to the following:
- Oxidative stress, inflammation, and neurodegeneration;
- Interaction between RONS and autophagy mechanisms;
- Oxidative stress and the microbiota gut–brain axis;
- The role of free radicals in inducing cell apoptosis;
- The improvement of antioxidant defenses and its effect on neurodegeneration.
Dr. Ferdinando Franzoni
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- neurodegeneration
- inflammation
- apoptosis
- autophagy
