Exercise-Induced Neuroplasticity: Insights from Physiological and Epigenetic Adaptations

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 1852

Special Issue Editors


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Guest Editor
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Interests: oxidative stress; brain function; neurodegeneration; antioxidant capability; physical exercise
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Interests: oxidative stress; brain function; neurodegeneration; antioxidant capability; physical exercise

Special Issue Information

Dear Colleagues,

Neuroplasticity denotes the ability of the central nervous system to organize, modify and adapt its circuits and neuronal connections in response to internal and external stimuli. In this regard, physical exercise has been widely shown to promote brain plasticity through the release of several neurotrophic factors that in turn affect neuronal metabolism, nerve growth, and new synaptic connections as well as trigger intracellular molecular pathways in order to ensure neuronal survival and prevent neurodegeneration. In addition, exercise has been proven to directly affect the expression of neuroplasticity-related genes through epigenetic modifications including DNA methylation, histone modifications and microRNAs (miRNAs).

We are pleased to invite you to submit your manuscript to our current Special Issue whose purpose is to investigate molecular and epigenetic mechanisms affecting exercise-induced neuroplasticity; both original research articles and reviews are welcome.

Research areas may include (but are not limited to) the following:

  • The effect of chronic and acute exercise on brain plasticity;
  • The role of neurotrophic factors;
  • Exercise and brain metabolism;
  • Physical activity and neuroplasticity in children and young adults;
  • The effect of exercise on brain health in neurodegenerative disorders;
  • Epigenetic modifications affecting brain plasticity;
  • Cerebral oxidative stress and exercise-induced antioxidant responses;
  • The role of lactate.

Dr. Ferdinando Franzoni
Dr. Giorgia Scarfò
Guest Editors

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Keywords

  • exercise
  • neuroplasticity
  • epigenetic modifications
  • neurotrophic factors
  • lactate
  • oxidative stress
  • synaptic changes

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Published Papers (1 paper)

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Review

13 pages, 2659 KiB  
Review
Sprint Interval Training Improves Brain-Derived Neurotropic Factor-Induced Benefits in Brain Health—A Possible Molecular Signaling Intervention
by Xueqiang Zhu, Wenjia Chen and Anand Thirupathi
Biology 2024, 13(8), 562; https://doi.org/10.3390/biology13080562 - 26 Jul 2024
Cited by 1 | Viewed by 1499
Abstract
Physical exercise can significantly impact our bodies, affecting our functional capacity, structure establishment, and molecular makeup. The magnitude of these changes depends on the specific exercise protocols used. For instance, low-to-moderate-intensity exercise can activate important molecular targets in the short term, such as [...] Read more.
Physical exercise can significantly impact our bodies, affecting our functional capacity, structure establishment, and molecular makeup. The magnitude of these changes depends on the specific exercise protocols used. For instance, low-to-moderate-intensity exercise can activate important molecular targets in the short term, such as BDNF-mediated signaling, while high-intensity exercise can maintain these signaling molecules in the active state for a longer term. This makes it challenging to recommend specific exercises for obtaining BDNF-induced benefits. Additionally, exercise-induced molecular signaling targets can have positive and negative effects, with some exercises blunting these targets and others activating them. For example, increasing BDNF concentration through exercise can be beneficial for brain health, but it may also have a negative impact on conditions such as bipolar disorder. Therefore, a deeper understanding of a specific exercise-mediated mechanistic approach is required. This review will delve into how the sprint exercise-mediated activation of BDNF could help maintain brain health and explore potential molecular interventions. Full article
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