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Biology
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Physiology and Pathophysiology of Obesity
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Physiology and Pathophysiology of Obesity

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 442

Special Issue Editor

Dr. Yifei Kang

E-Mail Website
Guest Editor
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Interests: diet-Induced obesity mice; dietary interavtion on metabolic disroders; metagenomics; metabolomics; transcriptiomcs

Special Issue Information

Dear Colleagues,

Obesity is a major public health concern as it increases the risk of developing chronic diseases such as type 2 diabetes, heart disease, stroke, and some cancers. Lifestyle interventions such as dietary changes, physical activity, and behavioral therapy are the first-line treatment for obesity. Among them, diet plays a paramount role in shaping the physiology and pathophysiology of obesity, exerting profound effects on both its development and progression. The intricate interplay between dietary intake and metabolic processes influences energy balance, adipose tissue function, hormonal regulation, and systemic inflammation. Therefore, understanding the impact of diet on the development and treatment of obesity is fundamental for the design of effective strategies.

This Special Issue aims to present a compilation of research focusing on the treatment effects of dietary interventions, as well as the pathophysiological mechanisms underlying obesity and its associated comorbidities.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Dietary style;
  • Dietary supplementation;
  • Functional food;
  • Alternative food.

I look forward to receiving your contributions.

Dr. Yifei Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary intervention
  • alternative food
  • food supplementation
  • weight loss
  • weight management
  • obesity comorbidities
  • obesity pathophysiology

Published Papers (1 paper)

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Research

21 pages, 2324 KiB  
Article
Effect of Liposomal Protium heptaphyllum (Alb.) March Extract in the Treatment of Obesity Induced by High-Calorie Diet
by Naiéle Sartori Patias, Eveline Aparecida Isquierdo Fonseca de Queiroz, Stela Regina Ferrarini, Gisele Facholi Bomfim, Danilo Henrique Aguiar, Adilson Paulo Sinhorin, Alexandre Aymberé Bello, Geovana Vicentini Fazolo da Silva, Larissa Cavalheiro and Valéria Dornelles Gindri Sinhorin
Biology 2024, 13(7), 535; https://doi.org/10.3390/biology13070535 - 17 Jul 2024
Viewed by 226
Abstract
Obesity, a chronic disease, resulted from excessive consumption of high-calorie foods, leading to an energy imbalance. Protium heptaphyllum (P. heptaphyllum) was used in folk medicine for its analgesic, anti-inflammatory, and healing properties. The association of the extract from P. heptaphyllum with [...] Read more.
Obesity, a chronic disease, resulted from excessive consumption of high-calorie foods, leading to an energy imbalance. Protium heptaphyllum (P. heptaphyllum) was used in folk medicine for its analgesic, anti-inflammatory, and healing properties. The association of the extract from P. heptaphyllum with nanotechnology was innovative for combining high technology with active ingredients that are easily accessible in the Amazon region. This study evaluated the effect of liposomes containing the ethyl acetate fraction of the crude extract of P. heptaphyllum leaves on obesity. Male Wistar rats treated with a high-calorie diet for 8 weeks to induce obesity received treatment with the liposome formulation containing P. heptaphyllum extract (1 mg/kg/day, via gavage) for 14 days. Morphological, metabolic, redox status, immunological, and histological parameters were evaluated in the adipose and liver tissue of the animals. The groups were divided as follows: C: control; P: liposomes containing extract; O: obese, and OP: obese + liposomes containing extract. The obesity model resulted in increases in body weight, caloric intake, body fat weight, and in the lipid profile. In adipose tissue, P decreased SOD (superoxide dismutase) activity in obese animals. In the liver, a positive modulation of the extract was observed in relation to glucose, amino acids, lactate, hepatoprotective action, and anti-inflammatory activity, with a decrease in interleukin 1β (IL-1β) in obese animals. The results showed an improvement in the functional and inflammatory aspects, but the treatment was not effective in alleviating general changes related to obesity, such as weight gain, fat, glucose, triglycerides, and inflammation in adipose tissue, highlighting the complexity of responses in different organs during obesity and treatment with P. heptaphyllum. Full article
(This article belongs to the Special Issue Physiology and Pathophysiology of Obesity)
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