Physiological and Structural Changes in Erythrocytes in Hypertensive Patients

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1836

Special Issue Editors


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Guest Editor
1. Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia
2. Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia
Interests: erythrocyte physiology; erythrocyte deformability; erythrocyte osmotic resistance; nitric oxide; oxidative stress; cardiovascular physiology; aging; hypertension; natural antioxidants

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Guest Editor
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia
Interests: enzymes; enzyme kinetics; sodium–potassium ATPase; experimental hypertension; sex differences; aging; antioxidants; membrane proteins; membrane ion transport

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Guest Editor
Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia
Interests: hypertension; blood pressure; aging; endothelial function; vascular physiology; experimental hypertension; nitric oxide; reactive oxygen species; vasoconstriction; vasorelaxation; vascular reactivity

Special Issue Information

Dear Colleagues,

Hypertension is a multifactorial disease that represents a major risk factor for renal, cardiovascular, and cerebrovascular diseases, and is a significant underlying cause of global mortality and morbidity. There are multiple indices to suggest that erythrocyte quality is impaired in conditions of hypertension. However, it is not always clear whether the physiological and structural abnormalities of erythrocytes are involved in the pathophysiology of hypertension, or if these changes occur as a consequence of increased blood pressure within the circulation.

The adequate function of erythrocytes is a basic requirement for the proper function of all tissues, organs, and organ systems in the human body. We believe that protecting erythrocyte quality leads to an improvement in the quality of macro- and microcirculation, with the potential to lower blood pressure.

We would like to invite you to submit original work or review articles for this Special Issue of Biology. Topics of interest include recent knowledge regarding erythrocyte membrane composition, membrane fluidity, deformability, ion channel function, Ca2+ homeostasis, oxidative stress markers, nitric oxide production, hemolysis, eryptosis, and “erythroprotection”, either in hypertensive patients or in animal models of hypertension.

Dr. Jana Radosinska
Dr. Norbert Vrbjar
Dr. Angelika Puzserova
Guest Editors

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Keywords

  • hypertension
  • erythrocyte properties
  • erythrocyte membrane
  • nitric oxide
  • membrane ion transport
  • oxidative stress
  • hemolysis
  • hemorheology
  • membrane fluidity
  • eryptosis

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Published Papers (1 paper)

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Research

17 pages, 3219 KiB  
Article
Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties
by Jana Radosinska, Marta Kollarova, Tomas Jasenovec, Dominika Radosinska, Norbert Vrbjar, Peter Balis and Angelika Puzserova
Biology 2023, 12(7), 1030; https://doi.org/10.3390/biology12071030 - 21 Jul 2023
Cited by 1 | Viewed by 1439
Abstract
Erythrocyte deformability, crucial for oxygen delivery to tissues, plays an important role in the etiology of various diseases. As the factor maintaining the erythrocyte deformability, nitric oxide (NO) has been identified. Reduced NO bioavailability also plays a role in the pathogenesis of hypertension. [...] Read more.
Erythrocyte deformability, crucial for oxygen delivery to tissues, plays an important role in the etiology of various diseases. As the factor maintaining the erythrocyte deformability, nitric oxide (NO) has been identified. Reduced NO bioavailability also plays a role in the pathogenesis of hypertension. Our aim was to determine whether aging and hypertension affect erythrocyte deformability and NO production by erythrocytes in experimental animals divided into six groups according to age (7, 20 and 52 weeks), labeled WKY-7, WKY-20 and WKY-52 for normotensive Wistar-Kyoto (WKY) rats, and SHR-7, SHR-20 and SHR-52 for spontaneously hypertensive rats (SHR). The filtration method for the determination of erythrocyte deformability and the fluorescent probe DAF-2 DA for NO production were applied. Deformability and NO production by erythrocytes increased at a younger age, while a decrease in both parameters was observed at an older age. Strain-related differences in deformability were observed at 7 and 52 weeks of age. SHR-7 had reduced deformability and SHR-52 had increased deformability compared with age-matched WKY. Changes in NO production under hypertensive conditions are an unlikely primary factor affecting erythrocyte deformability, whereas age-related changes in deformability are at least partially associated with changes in NO production. However, an interpretation of data obtained in erythrocyte parameters observed in SHRs of human hypertension requires precaution. Full article
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