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Biomedicines
Special Issues
Metabolic Disorders in Pregnancy: From (Epi)genetics to Functional Consequences 2.0
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Metabolic Disorders in Pregnancy: From (Epi)genetics to Functional Consequences 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1907

Special Issue Editors

Dr. Jasminka Štefulj

E-Mail Website1 Website2
Guest Editor
Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
Interests: (epi)genetics of complex diseases; obesity; diabetes; mental disorders; serotonin
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Gernot Desoye

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria
Interests: placenta; fetal growth; diabetes; obesity; insulin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic disorders in pregnancy are a growing health problem worldwide. The global epidemic of obesity is leading to an increased number of women who enter pregnancy with excessive body fat, predisposing them to pregnancy-related metabolic conditions such as gestational diabetes mellitus (GDM). Both maternal obesity and GDM are associated with serious short-term and long-term adverse consequences for mother and child. The aim of this Special Issue is to gather the latest studies that deepen our current understanding of the pathophysiological mechanisms involved in metabolic disorders in pregnancy, with a focus on maternal obesity and GDM. We are particularly interested in studies of genetic and epigenetic factors, their interactions, functional consequences at the molecular, cellular, and whole organism levels, and potential utility as diagnostic or prognostic biomarkers. Studies on the influence of fetal sex and the role of the placenta are also appreciated. Both original research articles and reviews are of interest.

Dr. Jasminka Štefulj
Prof. Dr. Gernot Desoye
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy
  • obesity
  • gestational diabetes mellitus
  • genetic variants
  • epigenetics
  • DNA methylation
  • histone modification
  • microRNA
  • sex differences
  • placenta

Published Papers (1 paper)

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Research

15 pages, 2730 KiB  
Article
Glucose, Insulin and Oxygen Modulate Expression of Serotonin-Regulating Genes in Human First-Trimester Trophoblast Cell Line ACH-3P
by Maja Perić, Marina Horvatiček, Veronika Tandl, Ivona Bečeheli, Alejandro Majali-Martinez, Gernot Desoye and Jasminka Štefulj
Biomedicines 2023, 11(6), 1619; https://doi.org/10.3390/biomedicines11061619 - 2 Jun 2023
Cited by 1 | Viewed by 1520
Abstract
Serotonin signaling plays an important role in regulating development and functions of the placenta. We hypothesized that metabolic disturbances associated with maternal obesity and/or gestational diabetes mellitus (GDM) affect placental serotonin homeostasis. Therefore, we examined the effects of high glucose (25 mM) and [...] Read more.
Serotonin signaling plays an important role in regulating development and functions of the placenta. We hypothesized that metabolic disturbances associated with maternal obesity and/or gestational diabetes mellitus (GDM) affect placental serotonin homeostasis. Therefore, we examined the effects of high glucose (25 mM) and insulin (10 nM)—two hallmarks of maternal obesity and GDM—on mRNA expression of key regulators of serotonin homeostasis, including serotonin transporter (SERT), tryptophan hydroxylase 1 (TPH1), and monoamine oxidase A (MAOA), in the first-trimester trophoblast cell line ACH-3P, focusing on oxygen levels characteristic of early human placental development. Glucose downregulated expression of SERT and MAOA independently of oxygen level and upregulated expression of TPH1 at 6.5% oxygen but not at 2.5% oxygen. Compared to 6.5% oxygen, 2.5% oxygen upregulated SERT and downregulated TPH1 expression, with no effect on MAOA expression. Insulin upregulated SERT only at 2.5% oxygen but had no effect on TPH1 and MAOA expression. These results suggest that maternal metabolic alterations in early pregnancy may be a driving force for changes in placental serotonin homeostasis. Full article
(This article belongs to the Special Issue Metabolic Disorders in Pregnancy: From (Epi)genetics to Functional Consequences 2.0)
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