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Biomedicines
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Advances in Nanomaterials for Drug Delivery 2.0
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Advances in Nanomaterials for Drug Delivery 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 12865

Special Issue Editors

Dr. Elisabete M. S. Castanheira

E-Mail Website
Guest Editor
Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: drug delivery systems; magnetic and plasmonic nanoparticles; (magneto)liposomes; bionanomaterials; combined cancer therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Sérgio R. S. Veloso

E-Mail Website
Guest Editor
Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: drug delivery systems; biomaterials; nanomaterials; colloids and interfaces; nanomedicine; nanosystems for theranostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last several decades, nanomedicine has provided various high-performance tools to overcome biomedical challenges that have resulted in numerous patents. Particularly, drug delivery systems enabled the surpassing of drug stability and solubility limits, improved the routes for drug administration, reduced the dose-associated toxicity, and enhanced the target specificity by exploring both active and passive delivery strategies.

The combination of different nanomaterials has opened paths for the development of smart multifunctional drug delivery systems, for example, the synergistic use of both therapeutic and diagnostic agents (i.e., theranostic agents) in a single drug carrier. These advancements have enabled the spatial and temporal manipulation of drug delivery systems and thus on-demand drug release upon an external stimulus. This control over drug release remains a major challenge, moving towards multimodal and multifunctional strategies as a means to optimize efficiency and efficacy.

This Special Issue aims to attract the academic and scientific communities within this biomedical field to contribute their developments in drug delivery systems based on nanomaterials. Original research articles and reviews are welcome, including those providing a fundamental understanding of the principles, fabrication, and application of traditional or innovative systems that demonstrate an advantage over current clinical formulations. The systems can include (but are not limited to) biomaterials, carbonaceous materials, as well as magnetic and/or plasmonic materials.

We look forward to receiving your contributions

Dr. Elisabete M. S. Castanheira
Dr. Sérgio R. S. Veloso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • on-demand delivery
  • target therapy
  • theranostic
  • nanomedicine
  • nanoparticles
  • nanomaterials
  • biomaterials
  • multifunctional materials

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Related Special Issue

Published Papers (5 papers)

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Research

Jump to: Review

21 pages, 3976 KiB  
Article
Time-Delayed Anticancer Effect of an Extremely Low Frequency Alternating Magnetic Field and Multimodal Protein–Tannin–Mitoxantrone Carriers with Brillouin Microspectroscopy Visualization In Vitro
by Anatolii A. Abalymov, Roman A. Anisimov, Polina A. Demina, Veronika A. Kildisheva, Alexandra E. Kalinova, Alexey A. Serdobintsev, Nadezhda G. Novikova, Dmitry B. Petrenko, Alexandr V. Sadovnikov, Denis V. Voronin and Maria V. Lomova
Biomedicines 2024, 12(2), 443; https://doi.org/10.3390/biomedicines12020443 - 16 Feb 2024
Viewed by 1615
Abstract
The effect of an extremely low frequency alternating magnetic field (ELF AMF) at frequencies of 17, 48, and 95 Hz at 100 mT on free and internalized 4T1 breast cancer cell submicron magnetic mineral carriers with an anticancer drug, mitoxantrone, was shown. The [...] Read more.
The effect of an extremely low frequency alternating magnetic field (ELF AMF) at frequencies of 17, 48, and 95 Hz at 100 mT on free and internalized 4T1 breast cancer cell submicron magnetic mineral carriers with an anticancer drug, mitoxantrone, was shown. The alternating magnetic field (100 mT; 17, 48, 95 Hz; time of treatment—10.5 min with a 30 s delay) does not lead to the significant destruction of carrier shells and release of mitoxantrone or bovine serum albumin from them according to the data of spectrophotometry, or the heating of carriers in the process of exposure to magnetic fields. The most optimal set of factors that would lead to the suppression of proliferation and survival of cells with anticancer drug carriers on the third day (in comparison with the control and first day) is exposure to an alternating magnetic field of 100 mT in a pulsed mode with a frequency of 95 Hz. The presence of magnetic nanocarriers in cell lines was carried out by a direct label-free method, space-resolved Brillouin light scattering (BLS) spectrometry, which was realized for the first time. The analysis of the series of integrated BLS spectra showed an increase in the magnetic phase in cells with a growth in the number of particles per cell (from 10 to 100) after their internalization. The safety of magnetic carriers in the release of their constituent ions has been evaluated using atomic absorption spectrometry. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Drug Delivery 2.0)
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26 pages, 18264 KiB  
Article
Preparation and Characterization of Novel Polyelectrolyte Liposomes Using Chitosan Succinate Layered over Chitosomes: A Potential Strategy for Colon Cancer Treatment
by Asmaa Mokhtar Yosef, Raghad Saleh Alqarni, Fai Yahya Sayd, Manar Saleem Alhawiti, Raghad M. Almahlawi, Kousalya Prabahar, Ubaidulla Uthumansha, Mansuor A. Alanazi, Mohamed El-Sherbiny, Nehal Elsherbiny and Mona Qushawy
Biomedicines 2024, 12(1), 126; https://doi.org/10.3390/biomedicines12010126 - 8 Jan 2024
Cited by 1 | Viewed by 1735
Abstract
Chitosan succinate is distinguished by its ability to shield the loaded drug from the acidic environment, localize and keep the drug at the colon site, and release the drug over an extended time at basic pH. The current study attempts to develop polyelectrolyte [...] Read more.
Chitosan succinate is distinguished by its ability to shield the loaded drug from the acidic environment, localize and keep the drug at the colon site, and release the drug over an extended time at basic pH. The current study attempts to develop polyelectrolyte liposomes (PEL), using chitosan and chitosan succinate (CSSC), as a carrier for liposomal-assisted colon target delivery of 5 fluorouracil (5FU). The central composite design was used to obtain an optimized formulation of 5FU-chitosomes. The chitosan-coated liposomes (chitosomes) were prepared by thin lipid film hydration technique. After that, the optimized formulation was coated with CSSC, which has several carboxylic (COOH) groups that produce an anionic charge that interacts with the cation NH2 in chitosan. The prepared 5FU-chitosomes formulations were evaluated for entrapment efficiency % (EE%), particle size, and in vitro drug release. The optimized 5FU-chitosomes formulation was examined for particle size, zeta potential, in vitro release, and mucoadhesive properties in comparison with the equivalent 5FU-liposomes and 5FU-PEL. The prepared 5FU-chitosomes exhibited high EE%, small particle size, low polydispersity index, and prolonged drug release. PEL significantly limited the drug release at acidic pH due to the deprotonation of carboxylate ions in CSSC, which resulted in strong repulsive forces, significant swelling, and prolonged drug release. According to a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, PEL treatment significantly decreased the viability of HT-29 cells. When compared to 5FU-liposome and 5FU-chitosome, the in vivo pharmacokinetics characteristics of 5FU-PEL significantly (p < 0.05) improved. The findings show that PEL enhances 5FU permeability, which permits high drug concentrations to enter cells and inhibits the growth of colon cancer cells. Based on the current research, PEL may be used as a liposomal-assisted colon-specific delivery. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Drug Delivery 2.0)
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14 pages, 2895 KiB  
Article
Redox-Active Cerium Fluoride Nanoparticles Selectively Modulate Cellular Response against X-ray Irradiation In Vitro
by Nikita N. Chukavin, Kristina O. Filippova, Artem M. Ermakov, Ekaterina E. Karmanova, Nelli R. Popova, Viktoriia A. Anikina, Olga S. Ivanova, Vladimir K. Ivanov and Anton L. Popov
Biomedicines 2024, 12(1), 11; https://doi.org/10.3390/biomedicines12010011 - 20 Dec 2023
Cited by 4 | Viewed by 1689
Abstract
Ionizing radiation-induced damage in cancer and normal cells leads to apoptosis and cell death, through the intracellular oxidative stress, DNA damage and disorders of their metabolism. Irradiation doses that do not lead to the death of tumor cells can result in the emergence [...] Read more.
Ionizing radiation-induced damage in cancer and normal cells leads to apoptosis and cell death, through the intracellular oxidative stress, DNA damage and disorders of their metabolism. Irradiation doses that do not lead to the death of tumor cells can result in the emergence of radioresistant clones of these cells due to the rearrangement of metabolism and the emergence of new mutations, including those in the genes responsible for DNA repair. The search for the substances capable of modulating the functioning of the tumor cell repair system is an urgent task. Here we analyzed the effect of cerium(III) fluoride nanoparticles (CeF3 NPs) on normal (human mesenchymal stem cells–hMSC) and cancer (MCF-7 line) human cells after X-ray radiation. CeF3 NPs effectively prevent the formation of hydrogen peroxide and hydroxyl radicals in an irradiated aqueous solution, showing pronounced antioxidant properties. CeF3 NPs are able to protect hMSC from radiation-induced proliferation arrest, increasing their viability and mitochondrial membrane potential, and, conversely, inducing the cell death of MCF-7 cancer cells, causing radiation-induced mitochondrial hyperpolarization. CeF3 NPs provided a significant decrease in the number of double-strand breaks (DSBs) in hMSC, while in MCF-7 cells the number of γ-H2AX foci dramatically increased in the presence of CeF3 4 h after irradiation. In the presence of CeF3 NPs, there was a tendency to modulate the expression of most analyzed genes associated with the development of intracellular oxidative stress, cell redox status and the DNA-repair system after X-ray irradiation. Cerium-containing nanoparticles are capable of providing selective protection of hMSC from radiation-induced injuries and are considered as a platform for the development of promising clinical radioprotectors. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Drug Delivery 2.0)
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21 pages, 4667 KiB  
Article
Design of Chitosan-Coated, Quercetin-Loaded PLGA Nanoparticles for Enhanced PSMA-Specific Activity on LnCap Prostate Cancer Cells
by Divesha Essa, Pierre P. D. Kondiah, Pradeep Kumar and Yahya E. Choonara
Biomedicines 2023, 11(4), 1201; https://doi.org/10.3390/biomedicines11041201 - 18 Apr 2023
Cited by 16 | Viewed by 3351
Abstract
Nanoparticles are designed to entrap drugs at a high concentration, escape clearance by the immune system, be selectively taken up by cancer cells, and release bioactives in a rate-modulated manner. In this study, quercetin-loaded PLGA nanoparticles were prepared and optimized to determine whether [...] Read more.
Nanoparticles are designed to entrap drugs at a high concentration, escape clearance by the immune system, be selectively taken up by cancer cells, and release bioactives in a rate-modulated manner. In this study, quercetin-loaded PLGA nanoparticles were prepared and optimized to determine whether coating with chitosan would increase the cellular uptake of the nanoparticles and if the targeting ability of folic acid as a ligand can provide selective toxicity and enhanced uptake in model LnCap prostate cancer cells, which express high levels of the receptor prostate-specific membrane antigen (PSMA), compared to PC-3 cells, that have relatively low PSMA expression. A design of experiments approach was used to optimize the PLGA nanoparticles to have the maximum quercetin loading, optimal cationic charge, and folic acid coating. We examined the in vitro release of quercetin and comparative cytotoxicity and cellular uptake of the optimized PLGA nanoparticles and revealed that the targeted nano-system provided sustained, pH-dependent quercetin release, and higher cytotoxicity and cellular uptake, compared to the non-targeted nano-system on LnCap cells. There was no significant difference in the cytotoxicity or cellular uptake between the targeted and non-targeted nano-systems on PC-3 cells (featured by low levels of PSMA), pointing to a PSMA-specific mechanism of action of the targeted nano-system. The findings suggest that the nano-system can be used as an efficient nanocarrier for the targeted delivery and release of quercetin (and other similar chemotherapeutics) against prostate cancer cells. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Drug Delivery 2.0)
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Review

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19 pages, 1604 KiB  
Review
Pathology and Treatment of Psoriasis Using Nanoformulations
by Divya Thirumal, Rakesh K. Sindhu, Shuchi Goyal, Aayush Sehgal, Ashok Kumar, Marianesan Arockia Babu and Pradeep Kumar
Biomedicines 2023, 11(6), 1589; https://doi.org/10.3390/biomedicines11061589 - 30 May 2023
Cited by 11 | Viewed by 3808
Abstract
Psoriasis (PSO) is an inflammatory skin condition that causes a variety of diseases and significantly decreases the life characteristics of patients, and substantially diminishes patients’ quality of life. PSO usually impairs the skin and is linked to various disorders. Inflammation pathology does not [...] Read more.
Psoriasis (PSO) is an inflammatory skin condition that causes a variety of diseases and significantly decreases the life characteristics of patients, and substantially diminishes patients’ quality of life. PSO usually impairs the skin and is linked to various disorders. Inflammation pathology does not only damage psoriatic skin; it shows how PSO impinges other body parts. Many variables interact with one another and can impact the etiology of psoriasis directly or indirectly. PSO has an effect on approximately 2% of the world’s population, and significant progress has been made in comprehending and treating the alternative PSO by novel drug delivery systems. Topical, systemic, biological, biomaterials, and phototherapy are some of the useful therapies for PSO. Nonetheless, topical treatments remain the gold standard for treating moderate PSO. The applicability of several nanocarrier systems, such as lipid nanoparticles, metallic nanoparticles, and certain phytocompounds, has been briefly explored. The present review focuses mainly on traditional therapeutic strategies as well as on breakthroughs in nanoformulations and drug delivery methods for several anti-psoriatic drugs. Full article
(This article belongs to the Special Issue Advances in Nanomaterials for Drug Delivery 2.0)
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