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Biomedicines
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Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches
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Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 5243

Special Issue Editor

Dr. Gurjit Singh

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA
Interests: osteoarthritis; pain; depression

Special Issue Information

Dear Colleagues,

Osteoarthritis (OA), the most common form of arthritis, is a leading cause of debilitating pain and disability, affecting more than 32 million people in the US. The prevalence and incidence of OA have been continuously increasing due to increases in lifespan and obesity.

This Special Issue aims to present evidence of the potential targets, therapeutic drugs, and nanoformulations, and their mechanisms in treating osteoarthritis and associated pain. We welcome original research and review papers focused on the mechanism and therapeutic potential of phytochemicals, peptides, and synthetic nanoparticle-based formulations that are engaged in improving osteoarthritic pain in preclinical and clinical studies. Furthermore, we encourage studies using in vivo and in vitro models to explore the mechanism of action and interaction of nanoformulations with molecular mediators of oxidative/nitrosative stress caused by osteoarthritic pain conditions.

Specific topics covered by this Special Issue include:

  • Basic and applied Osteoarthritic pain research.
  • Multidisciplinary Osteoarthritic pain research.
  • Osteoarthritis and comorbidities.
  • Drug studies involve the treatment of Osteoarthritis.
  • Genetics in Osteoarthritis.
  • Molecular mechanisms of Osteoarthritis and associated pain.

Dr. Gurjit Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • pain
  • cartilage degeneration
  • molecular pain pathway

Published Papers (5 papers)

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Research

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11 pages, 1485 KiB  
Article
Performance of Radiological and Biochemical Biomarkers in Predicting Radio-Symptomatic Knee Osteoarthritis Progression
by Ahmad Almhdie-Imjabbar, Hechmi Toumi and Eric Lespessailles
Biomedicines 2024, 12(3), 666; https://doi.org/10.3390/biomedicines12030666 - 16 Mar 2024
Viewed by 614
Abstract
Imaging biomarkers permit improved approaches to identify the most at-risk patients encountering knee osteoarthritis (KOA) progression. This study aimed to investigate the utility of trabecular bone texture (TBT) extracted from plain radiographs, associated with a set of clinical, biochemical, and radiographic data, as [...] Read more.
Imaging biomarkers permit improved approaches to identify the most at-risk patients encountering knee osteoarthritis (KOA) progression. This study aimed to investigate the utility of trabecular bone texture (TBT) extracted from plain radiographs, associated with a set of clinical, biochemical, and radiographic data, as a predictor of long-term radiographic KOA progression. We used data from the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium dataset. The reference model made use of baseline TBT parameters adjusted for clinical covariates and radiological scores. Several models based on a combination of baseline and 24-month TBT variations (TBT∆TBT) were developed using logistic regression and compared to those based on baseline-only TBT parameters. All models were adjusted for baseline clinical covariates, radiological scores, and biochemical descriptors. The best overall performances for the prediction of radio-symptomatic, radiographic, and symptomatic progression were achieved using TBT∆TBT parameters solely, with area under the ROC curve values of 0.658 (95% CI: 0.612–0.705), 0.752 (95% CI: 0.700–0.804), and 0.698 (95% CI: 0.641–0.756), respectively. Adding biochemical markers did not significantly improve the performance of the TBT∆TBT-based model. Additionally, when TBT values were taken from the entire subchondral bone rather than just the medial, lateral, or central compartments, better results were obtained. Full article
(This article belongs to the Special Issue Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches)
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22 pages, 7667 KiB  
Article
Can Combining Hyaluronic Acid and Physiotherapy in Knee Osteoarthritis Improve the Physicochemical Properties of Synovial Fluid?
by Ilie Onu, Robert Gherghel, Isabella Nacu, Florina-Daniela Cojocaru, Liliana Verestiuc, Daniela-Viorelia Matei, Dan Cascaval, Ionela Lacramioara Serban, Daniel Andrei Iordan, Alexandra Tucaliuc and Anca-Irina Galaction
Biomedicines 2024, 12(2), 449; https://doi.org/10.3390/biomedicines12020449 - 17 Feb 2024
Viewed by 1314
Abstract
Known as the degenerative disease of the knee with the highest prevalence, knee osteoarthritis (KOA) is characterized by a gradual destructive mechanism that, in severe cases, can provoke the need for total knee substitution. As the disease progresses, various enzymatic, immunological, and inflammatory [...] Read more.
Known as the degenerative disease of the knee with the highest prevalence, knee osteoarthritis (KOA) is characterized by a gradual destructive mechanism that, in severe cases, can provoke the need for total knee substitution. As the disease progresses, various enzymatic, immunological, and inflammatory processes abnormally degrade hyaluronic acid (HA), SF’s main component, and affect the concentrations of specific proteins, with the final results seriously endangering synovial fluid (SF)’s rheological and tribological features and characteristics. No effective treatments have been found to stop the progression of KOA, but the injection of HA-based viscoelastic gels has been considered (alone or combined with physiotherapy (PT)) as an alternative to symptomatic therapies. In order to evaluate the effect of viscosupplementation and PT on the characteristics of SF, SF aspirated from groups treated for KOA (HA Kombihylan® and groups that received Kombihylan® and complex PT) was analyzed and compared from analytical, spectrophotometrical, and rheological perspectives. In the patients treated with PT, the SF extracted 6 weeks after viscosupplementation had a superior elastic modulus (G′) and viscous moduli (G″), as well as a homogeneous distribution of proteins and polysaccharides. The viscosupplementation fluid improved the bioadhesive properties of the SF, and the use of the viscosupplementation fluid in conjunction with PT was found to be favorable for the distribution of macromolecules and phospholipids, contributing to the lubrication process and the treatment of OA-affected joints. Full article
(This article belongs to the Special Issue Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches)
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15 pages, 891 KiB  
Article
The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study
by Anthe Foubert, Nathalie Anne Roussel, Valérie-Anne Chantrain, Philip Maes, Lies Durnez, Sébastien Lobet, Catherine Lambert, Cédric Hermans and Mira Meeus
Biomedicines 2023, 11(9), 2479; https://doi.org/10.3390/biomedicines11092479 - 07 Sep 2023
Viewed by 952
Abstract
In people with haemophilia (PwH), joint pain is a major comorbidity that is often overlooked and under-treated. It is believed that, to ensure the most successful outcome, pain management should be tailored to the predominant pain phenotype (i.e., nociceptive, neuropathic and nociplastic). The [...] Read more.
In people with haemophilia (PwH), joint pain is a major comorbidity that is often overlooked and under-treated. It is believed that, to ensure the most successful outcome, pain management should be tailored to the predominant pain phenotype (i.e., nociceptive, neuropathic and nociplastic). The 2021 clinical criteria and grading system for nociplastic pain, established by the International Association for the Study of Pain (IASP), emphasize the necessity of early-stage identification and predominant pain type classification. Consistent with findings in other chronic musculoskeletal pain conditions, studies suggest that a subgroup of PwH suffers from nociplastic pain, i.e., pain arising from altered nociception rather than structural damage, but this has not yet been explored in PwH. This study aimed to identify PwH with “unlikely”, “possible” and “probable” nociplastic pain and investigate differences in anthropometric, demographic and clinical characteristics and psychological factors between subgroups of PwH and healthy individuals.: The IASP clinical criteria and grading system were used to classify pain types in adult men with moderate or severe haemophilia recruited from two Belgian haemophilia treatment centres. Statistical analyses were applied to study between-subgroup differences. Of 94 PwH, 80 PwH (85%) were classified with “unlikely” and 14 (15%) with “at least possible” nociplastic pain (including 5 PwH (5%) with “possible” and 9 PwH (10%) with “probable” nociplastic pain). PwH in both the “unlikely” and “at least possible” nociplastic pain groups showed significantly higher levels of unhelpful psychological factors compared to healthy individuals. Additionally, age may partially account for the observed differences in body height and psychological factors. Larger sample sizes may be needed to detect more subtle between-group differences. study confirmed the presence of nociplastic pain in haemophilia, categorising a notable subgroup as individuals who experience at least possible nociplastic pain. These exploratory insights may provide a starting point for future studies and the development of more effective and tailored pain management. Full article
(This article belongs to the Special Issue Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches)
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Review

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18 pages, 346 KiB  
Review
Pain Management Strategies in Osteoarthritis
by Luca Farinelli, Michele Riccio, Antonio Gigante and Francesco De Francesco
Biomedicines 2024, 12(4), 805; https://doi.org/10.3390/biomedicines12040805 - 04 Apr 2024
Viewed by 530
Abstract
Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to manage this disease. However, the current standard of care does not provide satisfactory pain relief for many patients. The pathophysiology of OA is complex, and its presentation [...] Read more.
Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to manage this disease. However, the current standard of care does not provide satisfactory pain relief for many patients. The pathophysiology of OA is complex, and its presentation as a clinical syndrome is associated with the pathologies of multiple joint tissues. Treatment options are generally classified as pharmacologic, nonpharmacologic, surgical, and complementary and/or alternative, typically used in combination to achieve optimal results. The goals of treatment are the alleviation of symptoms and improvement in functional status. Several studies are exploring various directions for OA pain management, including tissue regeneration techniques, personalized medicine, and targeted drug therapies. The aim of the present narrative review is to extensively describe all the treatments available in the current practice, further describing the most important innovative therapies. Advancements in understanding the molecular and genetic aspects of osteoarthritis may lead to more effective and tailored treatment approaches in the future. Full article
(This article belongs to the Special Issue Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches)
19 pages, 352 KiB  
Review
Pathogenic Mechanisms and Therapeutic Approaches in Obesity-Related Knee Osteoarthritis
by Russka Shumnalieva, Georgi Kotov, Plamena Ermencheva and Simeon Monov
Biomedicines 2024, 12(1), 9; https://doi.org/10.3390/biomedicines12010009 - 20 Dec 2023
Cited by 1 | Viewed by 1404
Abstract
The knee is the joint most frequently involved in osteoarthritis, a common joint disorder in the adult population that is associated with significant chronic joint pain, reduced mobility and quality of life. Recent studies have established an association between obesity and the development [...] Read more.
The knee is the joint most frequently involved in osteoarthritis, a common joint disorder in the adult population that is associated with significant chronic joint pain, reduced mobility and quality of life. Recent studies have established an association between obesity and the development of knee osteoarthritis that goes beyond the increased mechanical load on the knees as weight-bearing joints. This link is based on the maintenance of a chronic low-grade inflammation, altered secretion of adipokines by the adipose tissue and development of sarcopenia. Major adipokines involved in the pathogenesis of obesity-related knee osteoarthritis include adiponectin, which appears to have a protective effect, as well as leptin, resistin and visfatin, which are associated with higher pain scores and more severe structural damage. Joint pain in knee osteoarthritis may be both nociceptive and neuropathic and is the result of complex mechanisms driven by nerve growth factor, calcitonin gene-related peptide and pro-inflammatory cytokines. The role of endogenous cannabinoids and gut microbiota in common mechanisms between obesity and knee pain has recently been studied. The aim of the present review is to highlight major pathogenic mechanisms in obesity-related knee osteoarthritis with special attention on pain and to comment on possible therapeutic approaches. Full article
(This article belongs to the Special Issue Osteoarthritis and Associated Pain: Molecular Research and Novel Therapeutic Approaches)
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