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Biomedicines
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Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies...
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Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1501

Special Issue Editors

Dr. Francesco Massari

E-Mail Website
Guest Editor
Cardiology Department, Perinei Hospital, Bari, Italy
Interests: heart failure; cardiomyopathies; cardiac physiology; cardiorenal syndrome; cardiovascular pharmacology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Pietro Scicchitano

E-Mail Website
Guest Editor
Cardiology Department, Perinei Hospital, Bari, Italy
Interests: noninvasive assessment; heart failure; arrhythmias; preventive cardiology; cardiovascular pharmacology; cardio-oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases are the leading cause of death worldwide. The relationship between cardiac and vascular structures is not always considered, and these diseases are often underdiagnosed.

The focus of this Special Issue is to develop new insights into the pathogenesis of vascular alterations in cardiac diseases by outlining the complex genetic, biochemical, and molecular aspects at the center of these alterations.

Early identification of cardiac and vascular diseases as well as the correct evaluation of mechanisms and pathogenetic pathways will help to promote the development of targeted therapies.

This Special Issue also aims to cover the landscape of cardiovascular pharmacology. Authors are invited to contribute their research in the field of pharmacological approaches to cardiac and vascular diseases by outlining the most recent advances in therapies and treatments.

The combination of research in pathogenesis and pharmacology will give a comprehensive overview of cardiovascular diseases and the attempts to improve outcomes for patients.

Dr. Francesco Massari
Dr. Pietro Scicchitano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endothelial function
  • cardiomyopathies
  • cardiovascular pharmacology
  • cardiac therapeutics
  • noninvasive vascular treatments
  • molecular cardiac biomarkers
  • molecular vascular biomarkers

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Related Special Issue

Published Papers (2 papers)

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9 pages, 339 KiB  
Article
Adverse Drug Reactions of Cardiovascular Classes of Medicines—Data for Bulgarian Population
by Zornitsa Mitkova, Anita Dimova, Guenka Petrova and Maria Dimitrova
Biomedicines 2024, 12(10), 2163; https://doi.org/10.3390/biomedicines12102163 - 24 Sep 2024
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Abstract
Objective: Hypertensionis one of the most common chronic diseases, affecting more than 20% of the population. The side effects experienced due to antihypertensive medications, such as tiredness, muscle pain, and insomnia, are often a significant predictor of poor adherence to therapy. The goal [...] Read more.
Objective: Hypertensionis one of the most common chronic diseases, affecting more than 20% of the population. The side effects experienced due to antihypertensive medications, such as tiredness, muscle pain, and insomnia, are often a significant predictor of poor adherence to therapy. The goal of the current study is to present the frequency, type, seriousness, and severity of adverse drug reactions reported to the BDA via Individual Case Safety Reports (ICSRs) and following differentiation of messages found in more than one patient. Methods: We conducted a retrospective analysis of the reported adverse drug reactions (ADRs) reported in the Bulgarian Drug Agency database after treatment with antihyperlipidemic medicines, angiotensin-converting enzyme (ACE) inhibitors, and sartans for the period 2017–2021. Each ICSR form was observed, and data for suspected medicine and type of adverse reaction was analyzed. Results: The total number of processed notifications for adverse drug reactions (ADRs) included in the database is 142. The highest number of ADRs was reported for ARB (58), followed by antihyperlipidemic medicines (55) and ACE inhibitors (29). Most of the assessed adverse events experienced by more than one patient fall into the probable and related categories based on the Global Introspection method classification. Therefore, they have been investigated and are consistent with exposure in the population. Conclusions: Cardiovascular medicines from the groups of ACE inhibitors, sartans, and statins have a high share of reported ADRs in the BDA system. Some of them are severe and need further investigation. Full article
(This article belongs to the Special Issue Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies (2nd Edition))
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12 pages, 2909 KiB  
Case Report
Upper Vascular Thoracic Outlet Syndrome: A Case Study
by Agnieszka Wierciak-Rokowska, Agnieszka Sliwka, Mikolaj Maga, Mateusz Gajda, Katarzyna Bogucka, Pawel Kaczmarczyk and Pawel Maga
Biomedicines 2024, 12(8), 1829; https://doi.org/10.3390/biomedicines12081829 - 12 Aug 2024
Viewed by 596
Abstract
Thoracic outlet syndrome (TOS) is recognised in approximately 8% of the population. Vascular presentation is rare and diagnosis is often elusive due to its rarity. As episodes of TOS in the upper extremities are rare, proven protocols for rehabilitation management are lacking. The [...] Read more.
Thoracic outlet syndrome (TOS) is recognised in approximately 8% of the population. Vascular presentation is rare and diagnosis is often elusive due to its rarity. As episodes of TOS in the upper extremities are rare, proven protocols for rehabilitation management are lacking. The purpose of our article is to present a clinical examination protocol and a treatment protocol for patients after an episode of venous thrombosis in the upper limb (VTOS). We report the case of a middle-aged woman with right venous TOS with pain in the right upper extremity, accompanied by oedema and mild violet discolouration. The results after 10 sessions of physiotherapy were as follows: a reduction in symptoms of approximately 40%, an improvement of approximately 15% in sports performance, and an improvement of approximately 25% in work. There was also an improvement in the results of TOS provocation tests, i.e., a 50–100% improvement in pulse rate and about 30% less discolouration in the extremity. Additionally, there was a significant improvement in posture between the two sides of the upper quadrant. The results after 10 physiotherapy sessions are surprising due to chronic disease after the thrombosis episode. It appears that even after a long period of time since diagnosis, improvement is possible. Full article
(This article belongs to the Special Issue Cardiac and Vascular Diseases: Pathogenesis, Pharmacological Treatments, Advances in Therapies (2nd Edition))
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