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Biomedicines
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Advanced Research in Interstitial Lung Diseases
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Advanced Research in Interstitial Lung Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 5689

Special Issue Editor

Dr. Pin-Kuei Fu

E-Mail Website
Guest Editor
1. Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
2. Integrated Care Center of Interstitial Lung Disease, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Interests: interstitial lung disease; pulmonary physiology; outcome prediciton; new drug development in ILD

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a paper to this Special Issue of “Advanced Research on Interstitial Lung Diseases”.

Interstitial lung diseases (ILDs) encompass a group of diverse lung disorders characterized by the inflammation and scarring of lung tissue, leading to impaired lung function. Some common ILDs include idiopathic pulmonary fibrosis (IPF), sarcoidosis, and hypersensitivity pneumonitis. Unfortunately, there are challenges in promptly and accurately diagnosing these conditions. Accurate diagnosis plays a pivotal role in predicting outcomes and effectively addressing the condition, as treatment approaches vary across different ILD subcategories, and individuals exhibit varying responses to conventional therapies.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Early and accurate diagnosis of interstitial lung abnormality (ILA).
  2. Specific biomarkers for outcome prediction and personalized treatment approaches in IPF or connective-tissue-disease-associated ILD (CTD-ILD).
  3. Hypersensitivity pneumonitis.
  4. Research on rare interstitial lung disease.
  5. Using machine learning or an artificial intelligence (AI) model in the research on ILD.
  6. Long-term follow-up cohort study in ILD.
  7. Rheumatoid-arthritis-associated ILD (RA-ILD) and Sjogren’s-syndrome-associated ILD.
  8. Genetic markers for susceptibility and prognosis.
  9. The impact of comorbidity on the long-term outcomes of IPF or CTD-ILD (such as pulmonary hypertension, emphysema…).

I look forward to receiving your contributions.

Dr. Pin-Kuei Fu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypersensitivy pneumonitis
  • interstitial lung abnormality (ILA)
  • connective-tissue-disease-associated ILD (CTD-ILD)
  • idiopathic pulmonary fibrosis (IPF)
  • rheumatoid-arthritis-associated ILD (RA-ILD)
  • sjogren’s-syndrome-associated ILD
  • genetic markers
  • biomarkers
  • machine learning
  • artificial intelligence
  • comorbidity
  • high-resolution computed tomography
  • image analysis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

25 pages, 10336 KiB  
Review
Sarcoidosis versus Granulomatous and Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency: A Comparative Review
by Helena Buso, Claudia Discardi, Patrick Bez, Francesco Muscianisi, Jessica Ceccato, Cinzia Milito, Davide Firinu, Nicholas Landini, Mark G. Jones, Carla Felice, Marcello Rattazzi, Riccardo Scarpa and Francesco Cinetto
Biomedicines 2024, 12(7), 1503; https://doi.org/10.3390/biomedicines12071503 - 6 Jul 2024
Cited by 3 | Viewed by 2464
Abstract
Sarcoidosis and Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) are two rare entities primarily characterised by the development of Interstitial Lung Disease (ILD) in the context of systemic immune dysregulation. These two conditions partially share the immunological background and pathologic findings, with granuloma [...] Read more.
Sarcoidosis and Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) are two rare entities primarily characterised by the development of Interstitial Lung Disease (ILD) in the context of systemic immune dysregulation. These two conditions partially share the immunological background and pathologic findings, with granuloma as the main common feature. In this narrative review, we performed a careful comparison between sarcoidosis and GLILD, with an overview of their main similarities and differences, starting from a clinical perspective and ending with a deeper look at the immunopathogenesis and possible target therapies. Sarcoidosis occurs in immunocompetent individuals, whereas GLILD occurs in patients affected by common variable immunodeficiency (CVID). Moreover, peculiar extrapulmonary manifestations and radiological and histological features may help distinguish the two diseases. Despite that, common pathogenetic pathways have been suggested and both these disorders can cause progressive impairment of lung function and variable systemic granulomatous and non-granulomatous complications, leading to significant morbidity, reduced quality of life, and survival. Due to the rarity of these conditions and the extreme clinical variability, there are still many open questions concerning their pathogenesis, natural history, and optimal management. However, if studied in parallel, these two entities might benefit from each other, leading to a better understanding of their pathogenesis and to more tailored treatment approaches. Full article
(This article belongs to the Special Issue Advanced Research in Interstitial Lung Diseases)
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22 pages, 1319 KiB  
Review
Club Cells—A Guardian against Occupational Hazards
by Marina Ruxandra Otelea, Corina Oancea, Daniela Reisz, Monica Adriana Vaida, Andreea Maftei and Florina Georgeta Popescu
Biomedicines 2024, 12(1), 78; https://doi.org/10.3390/biomedicines12010078 - 28 Dec 2023
Viewed by 2714
Abstract
Club cells have a distinct role in the epithelial repair and defense mechanisms of the lung. After exposure to environmental pollutants, during chronic exposure, the secretion of club cells secretory protein (CCSP) decreases. Exposure to occupational hazards certainly has a role in a [...] Read more.
Club cells have a distinct role in the epithelial repair and defense mechanisms of the lung. After exposure to environmental pollutants, during chronic exposure, the secretion of club cells secretory protein (CCSP) decreases. Exposure to occupational hazards certainly has a role in a large number of interstitial lung diseases. According to the American Thoracic Society and the European Respiratory Society, around 40% of the all interstitial lung disease is attributed to occupational hazards. Some of them are very well characterized (pneumoconiosis, hypersensitivity pneumonitis), whereas others are consequences of acute exposure (e.g., paraquat) or persistent exposure (e.g., isocyanate). The category of vapors, gases, dusts, and fumes (VGDF) has been proven to produce subclinical modifications. The inflammation and altered repair process resulting from the exposure to occupational respiratory hazards create vicious loops of cooperation between epithelial cells, mesenchymal cells, innate defense mechanisms, and immune cells. The secretions of club cells modulate the communication between macrophages, epithelial cells, and fibroblasts mitigating the inflammation and/or reducing the fibrotic process. In this review, we describe the mechanisms by which club cells contribute to the development of interstitial lung diseases and the potential role for club cells as biomarkers for occupational-related fibrosis. Full article
(This article belongs to the Special Issue Advanced Research in Interstitial Lung Diseases)
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