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Biomedicines
Special Issues
Kawasaki Disease
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Kawasaki Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 729

Special Issue Editor

Dr. Kazuyoshi Saito

E-Mail Website
Guest Editor
Department of Pediatrics, Fujita Health University, Toyoake, Japan
Interests: kawasaki disease

Special Issue Information

Dear Colleagues,

We are pleased to announce the production of a Special Issue on Kawasaki disease. This issue will focus on the latest research findings and developments pertaining to Kawasaki disease, including topics such as micro RNAs, cytokine profiles in serum and urine, electrophysiology such as HR variability, QTc and QT dispersion.

Kawasaki disease is a systemic vasculitis with unknown etiology that especially affect coronary arteries, potentially leading to the development of coronary artery aneurysms. We would like to focus on the pathophysiology of these vasculitis with respect to microRNAs and cytokines and also wish to establish an exact diagnosis through the help of various elements of electrophysiology. 

We invite submissions in the form of original research articles and reviews that address these topics and will help to advance our understanding of Kawasaki disease.

Dr. Kazuyoshi Saito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Kawasaki disease
  • micro RNAs
  • cytokine profiles in serum and urine
  • electrophysiology
  • HR variability
  • QTc and QT dispersion

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Published Papers (2 papers)

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Research

17 pages, 1615 KiB  
Article
Kawasaki Disease Diagnosis and Treatment in over 1000 Patients: A Continuum of Dysregulated Inflammatory Responses
by Stejara A. Netea, Giske Biesbroek, Diana van Stijn, Sietse Q. Nagelkerke, Kawasaki Study Group, CAHAL Group, KIRI Group, Irene M. Kuipers and Taco W. Kuijpers
Biomedicines 2024, 12(9), 2014; https://doi.org/10.3390/biomedicines12092014 - 3 Sep 2024
Viewed by 224
Abstract
Background: Kawasaki disease (KD) is a pediatric vasculitis, leading to coronary artery aneurysms (CAAs) in ~4–14%. Attention to the etiology and course of KD was generated by the close mimic of a SARS-CoV-2-induced phenotype, called multisystem inflammatory syndrome in children (MIS-C). Methods: A [...] Read more.
Background: Kawasaki disease (KD) is a pediatric vasculitis, leading to coronary artery aneurysms (CAAs) in ~4–14%. Attention to the etiology and course of KD was generated by the close mimic of a SARS-CoV-2-induced phenotype, called multisystem inflammatory syndrome in children (MIS-C). Methods: A total of 1179 cases were collected from 2012 with ~50% of cases retrospectively included. Clinical characteristics were described and risk factors for CAA (persistence) were investigated. Phenotypic patterns of the prospectively included KD patients were evaluated. These patterns were also compared to the seronegative KD and seropositive MIS-C cases identified during the SARS-CoV-2 pandemic. Results: KD mostly affected boys and children < 5 years. IVIG resistance, CAAs, and giant CAAs occurred in 24.5%, 21.4%, and 6.6%, respectively. Giant CAAs were significantly more likely to normalize to a normal Z score in patients that were younger than 2.5 years old at the time of initial giant CAA (χ2 test p = 0.02). In our prospective (SARS-CoV-2-seronegative) KD series, there was a diminishing male predominance over time, whereas the proportions of incomplete presentations (p < 0.001) and patients with circulatory shock (p = 0.04) increased since the COVID-19 pandemic. Pre- and post-pandemic KD cases presented with different levels of C-reactive protein, thrombocyte counts, and hemoglobin levels over the years. Compared to pandemic KD, SARS-CoV-2-seropositive MIS-C patients were older (p < 0.001), and more often required intensive care admission (p < 0.001), with a gradual decrease over time between 2020 and 2022 (p = 0.04). KD carried a substantial risk of CAA development in contrast to MIS-C. Conclusion: the phenotypic changes seen over the last twelve years of our prospective follow-up study suggest a spectrum of hyperinflammatory states with potentially different triggering events within this clinical entity. Full article
(This article belongs to the Special Issue Kawasaki Disease)
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13 pages, 557 KiB  
Article
Coronary Arteries Lesions in Kawasaki Disease: Risk Factors in an Italian Cohort
by Elisabetta Morana, Fiorentina Guida, Laura Andreozzi, Leonardo Frazzoni, Lucia Augusta Baselli, Francesca Lami, Elena Corinaldesi, Cristina Cicero, Lorenzo Mambelli, Barbara Bigucci, Andrea Taddio, Chiara Ghizzi, Michela Cappella, Paola Fernicola, Marcello Lanari, Rocco Maurizio Zagari and Marianna Fabi
Biomedicines 2024, 12(9), 2010; https://doi.org/10.3390/biomedicines12092010 - 3 Sep 2024
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Abstract
Background: Kawasaki disease (KD) is a systemic vasculitis of medium arteries, particularly involving coronary arteries. Coronary artery lesions (CALs) is the most serious complication in the acute stage, potentially leading to ischemic cardiomyopathy, myocardial infarction and sudden death. Environmental factors and genetic [...] Read more.
Background: Kawasaki disease (KD) is a systemic vasculitis of medium arteries, particularly involving coronary arteries. Coronary artery lesions (CALs) is the most serious complication in the acute stage, potentially leading to ischemic cardiomyopathy, myocardial infarction and sudden death. Environmental factors and genetic background contribute to individual susceptibility to develop CALs. The aim of this study was to define the risk factors for CALs in an Italian cohort. Methods: Data of KD patients from 10 Italian sites were registered into a REDCap database where demographic and clinical data, laboratory findings and coronary status were recorded. KD was diagnosed according to AHA definition. We used multiple logistic regression analysis to identify independent risk factors for CALs. Results: A total of 517 patients were enrolled, mainly Caucasians (83.6%). Presentation was complete in 321 patients (62.8%) and IVIG responsiveness in 360 (70%). CALs developed in 136/517 (26.31%). Gender, age, ethnicity, clinical presentation, fever duration, non-coronary cardiac events, Hb, albumin and CRP were significantly different between patients with and without CALs, while seasonality was not. Male gender, age < 18 months, Asian ethnicity, incomplete presentation and fever > 10 days were independent risk factors for CALs. Conclusions: Age younger than 18 months, incomplete KD and longer fever duration are risk factors for CALs. Asian ethnicity also represents a risk factor in our Italian Cohort. Full article
(This article belongs to the Special Issue Kawasaki Disease)
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