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Biomedicines
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Peripheral Artery Disease and Diabetic Foot Ulcer: From Bench to...
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Peripheral Artery Disease and Diabetic Foot Ulcer: From Bench to Clinic (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2851

Special Issue Editors

Prof. Dr. Irene Hinterseher

E-Mail Website
Guest Editor
Berlin Institute of Health, Vascular Surgery Clinic, Charité—Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
Interests: revascularization; vascular; endothelial; growth factor; arterial disease
Special Issues, Collections and Topics in MDPI journals
Dr. Racha El Hage

E-Mail Website
Guest Editor
Department of Vascular Surgery, Universitätsklinikum Ruppin-Brandenburg, Fehrbelliner Str. 38, 16816 Neuruppin, Germany
Interests: arterial disease; microbiome; diabetes and endocrinology; gastroenterology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peripheral artery diseases (PAD) and diabetic foot ulcers (DFU) are life-threatening diseases in the Western world, with crucial importance to the medical field, as they have a major impact on the patient’s quality of life and lead to significant costs for the healthcare system. DFU represent a chronic complication in patients with diabetes; they are often associated with neuropathy and/or peripheral artery disease (PAD) of the lower limb in diabetic patients. PAD is a result of atherosclerosis. The major complication of DFU and PAD is lower limb amputation. Diagnosing PAD is a challenge, as it is asymptomatic in most patients in the early stages and it presents in various ways. Conventional treatments for DFU, including debridement, revascularization, management of infection, and off-loading, have not been shown to be effective enough, and they were not able to reduce the amputation rate. As a result, alternative or additional treatment and new therapeutical approaches in regenerative medicine are required. Furthermore, extra clinical data concerning the risk factors of PAD and DFU, as well as their impact on patients' lives and the healthcare system, are still needed. Molecular inflammatory processes initiating the progress of PAD in diabetics and non-diabetics are still unclear and need to be investigated to create new therapeutical approaches.

Prof. Dr. Irene Hinterseher
Dr. Racha El Hage
Guest Editors

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Keywords

  • peripheral artery diseases
  • diabetic foot ulcer
  • atherosclerosis
  • regenerative medicine
  • inflammatory

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Published Papers (2 papers)

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14 pages, 2972 KiB  
Article
Impact of Peripheral Angioplasty on Wound Oxygenation and Healing in Patients with Chronic Limb-Threatening Ischemia Measured by Near-Infrared Spectroscopy
by Johanna Schremmer, Manuel Stern, Sven Baasen, Patricia Wischmann, Ramy Foerster, Miriam Schillings, Kálmán Bódis, Roberto Sansone, Christian Heiss, Malte Kelm and Lucas Busch
Biomedicines 2024, 12(8), 1805; https://doi.org/10.3390/biomedicines12081805 - 8 Aug 2024
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Abstract
Managing chronic limb-threatening ischemia (CLTI) is challenging due to difficulties in assessing tissue oxygen saturation in ulcers. Near-infrared spectroscopy (NIRS) is a non-invasive method for measuring tissue oxygen saturation (StO2). This study evaluated the effects of endovascular treatment (EVT) on StO [...] Read more.
Managing chronic limb-threatening ischemia (CLTI) is challenging due to difficulties in assessing tissue oxygen saturation in ulcers. Near-infrared spectroscopy (NIRS) is a non-invasive method for measuring tissue oxygen saturation (StO2). This study evaluated the effects of endovascular treatment (EVT) on StO2 and wound healing in CLTI patients, comparing NIRS to standard ankle–brachial index (ABI) measurements. Using the Duesseldorf PTA Registry, 43 CLTI patients were analyzed: 27 underwent EVT, and 16 received conservative treatment. ABI assessed macrocirculation, while NIRS measured wound, wound area, and mean foot StO2 at baseline, post-EVT, and four-month follow-up. Wound severity was classified by wound area and wound, ischemia, and foot infection (WIfI) score. Wound StO2 increased significantly (median (interquartile range (IQR)), 38 (49.3) to 60 (34.5)%, p = 0.004), as did wound area StO2 (median (IQR), 70.9 (21.6) to 72.8 (18.3)%, p < 0.001), with no significant changes in the control group by four-month follow-up. Wound area decreased significantly after EVT (mean ± SD, 343.1 ± 267.8 to 178.1 ± 268.5 mm2, p = 0.01) but not in the control group. Changes in wound StO2, wound area StO2, and WIfI score correlated with wound area reduction, unlike ABI. This small exploratory study shows that NIRS-measured StO2 improvements after EVT correlate with reduced wound area and WIfI scores, highlighting NIRS as a potential enhancement for CLTI wound management in addition to ABI. Full article
(This article belongs to the Special Issue Peripheral Artery Disease and Diabetic Foot Ulcer: From Bench to Clinic (2nd Edition))
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9 pages, 1295 KiB  
Brief Report
Results of the Phase 1 Open-Label Safety Study of Umbilical Cord Lining Mesenchymal Stromal/Stem Cells (Corlicyte®) to Heal Chronic Diabetic Foot Ulcers
by Cecilia C. Low Wang, Tae Chong, Garrett Moore, Benjamin Echalier, Nicola Haakonsen, James E. Carter, Jr., David Mathes, Judith Hsia, Toan Thang Phan, Ivor J. Lim and Brian M. Freed
Biomedicines 2024, 12(6), 1375; https://doi.org/10.3390/biomedicines12061375 - 20 Jun 2024
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Abstract
Background: Mesenchymal stromal/stem cells (MSCs) play a critical role in wound healing. Corlicyte® is an MSC product derived from allogeneic umbilical cord tissue donated under an institutional review board-approved protocol and processed in accordance with section 501(a)(2)(B) of the Federal Food, Drug, [...] Read more.
Background: Mesenchymal stromal/stem cells (MSCs) play a critical role in wound healing. Corlicyte® is an MSC product derived from allogeneic umbilical cord tissue donated under an institutional review board-approved protocol and processed in accordance with section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic Act. This open-label phase 1 trial was performed under a United States Food and Drug Administration Investigational New Drug Application to establish the safety and tolerability of Corlicyte® in patients with diabetes and chronic diabetic foot ulcer (DFU). Methods: Escalating doses were applied topically twice a week for up to 8 weeks after ulcer debridement, wound photography, and measurement. Subjects were followed for 4 weeks after the treatment phase. Adverse events were assessed at every visit. Results: Nine subjects in 2 dosing cohorts completed the trial. No subjects experienced a serious adverse reaction to Corlicyte® or the development of anti-human leukocyte antigen (HLA) antibodies. Sixty percentage of subjects in the lower dose cohort experienced ulcer closure by Day 70 of follow-up, while the mean ulcer size was reduced by 54–67% in the other subjects. Conclusions: Topical administration of Corlicyte®, a novel biologic therapy consisting of allogeneic umbilical cord lining MSCs, appeared safe and tolerable and resulted in a significant decrease in ulcer area, demonstrating its potential as a therapy for healing of chronic DFU. Full article
(This article belongs to the Special Issue Peripheral Artery Disease and Diabetic Foot Ulcer: From Bench to Clinic (2nd Edition))
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