Blood Microrheology in Health and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 July 2023)
Special Issue Editor
Interests: hemodynamics and microcirculation in health and disease; biofluid dynamics and mechanics; biomedical imaging and bio-microscopy, both in vitro and in vivo (in animals and humans); biomedical and computer engineering and informatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The red blood cells (RBCs) are a crucial factor affecting normal blood microfluidics since the plasma flows in a completely different way without them. Under specific conditions, and with the contribution of other blood cells and proteins, the aggregability increases to such a degree that local microthrombi are formed. In addition, hemodynamics plays an important role since the behavior of blood changes at very low or high shear rates and stresses. Some of the RBC properties that affect the microrheology of blood are deformability, aggregability, membrane viscosity, cytoplasmic viscosity, and endurance to shear stress. Some of the related pathological conditions are microthrombosis, sickle cell disease, and related retinopathy and nephropathy.
In addition, in the process of microthrombosis, the coagulation pathways are essential, and the drugs that are used today target one or more of the coagulation factors. However, most studies are at the clinical level and not at the microrheology level either in vivo or in vitro.
Biomarkers are commonly used in medicine for characterizing a normal or abnormal biological process or disease or pharmacological response. Biomarkers can be biochemical molecules or physical quantities–properties of the body at the systemic, tissue, or molecular level.
The scope of this Special Issue is to accept original research and reviews on the latest developments on blood cell properties and biomarkers related to blood microfluidics, and/or on how blood microfluidics may change under the influence of disease or drugs inside microvessels in vivo or in vitro.
Dr. Aristotle G. Koutsiaris
Guest Editor
Manuscript Submission Information
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Keywords
- blood cell
- aggregability
- viscosity
- velocity
- shear rate
- microrheology
- microvessels
- disease
- thrombosis
- biomarkers
- anticoagulation drugs
