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Biomedicines
Special Issues
Therapeutic Potential of Adipose-Derived Stem Cells
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Therapeutic Potential of Adipose-Derived Stem Cells

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 9811

Special Issue Editors

Dr. Jung-pan Wang

E-Mail Website
Guest Editor
1. Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112201, Taiwan
2. Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei 112201, Taiwan
Interests: adipose-derived stem cells (ADSCs); infant ADSCs; chondrogenic differentiation
Dr. Ming-Hsiao Hu

E-Mail Website
Guest Editor
Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei 100229, Taiwan
Interests: spine surgery; minimally invasive spinal surgery

Special Issue Information

Dear Colleagues,

We are pleased to announce the special issue entitled “Therapeutic Potential of Adipose-Derived Stem Cells (ADSCs)” that aims to collect scientific publications including original and review papers in the field of ADSCs treatment.

Due to the easy collection, multi-potentiality, and elevated responsiveness to different environmental stimuli, ADSCs have been an attractive candidate cell in tissue engineering. Mesenchymal stem cell regeneration studies are provided as an alternative to prevent the disadvantages that using grafts to reconstruct injured sites of articular cartilage and peripheral nerve, including limited sources of donor cartilage, scar formation of the sutured site may inhibit regeneration and cause morbidity to donor sites. In this issue, we target basic and preclinical investigations in ADSCs application.

Dr. Jung-pan Wang
Dr. Ming-Hsiao Hu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipose-derived stem cells (ADSCs)
  • multilineage differentiation
  • cell expansion
  • age of stem cell

Published Papers (3 papers)

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Research

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19 pages, 7691 KiB  
Article
PLGA/Gelatin/Hyaluronic Acid Fibrous Membrane Scaffold for Therapeutic Delivery of Adipose-Derived Stem Cells to Promote Wound Healing
by Chia-Fen Hsieh, Chih-Hao Chen, Hao-Hsi Kao, Darshan Tagadur Govindaraju, Banendu Sunder Dash and Jyh-Ping Chen
Biomedicines 2022, 10(11), 2902; https://doi.org/10.3390/biomedicines10112902 - 11 Nov 2022
Cited by 13 | Viewed by 2297
Abstract
Hyaluronic acid (HA) has been suggested to be a preferential material for the delivery of adipose-derived stem cells (ASCs) in wound healing. By incorporating HA in electrospun poly (lactide-co-glycolide) (PLGA)/gelatin (PG) fibrous membrane scaffolds (FMS), we aim to fabricate PLGA/gelatin/HA (PGH) FMS to [...] Read more.
Hyaluronic acid (HA) has been suggested to be a preferential material for the delivery of adipose-derived stem cells (ASCs) in wound healing. By incorporating HA in electrospun poly (lactide-co-glycolide) (PLGA)/gelatin (PG) fibrous membrane scaffolds (FMS), we aim to fabricate PLGA/gelatin/HA (PGH) FMS to provide a milieu for 3D culture and delivery of ASCs. The prepared FMS shows adequate cytocompatibility and is suitable for attachment and growth of ASCs. Compared with PG, the PGH offers an enhanced proliferation rate of ASCs, shows higher cell viability, and better maintains an ASC-like phenotype during in vitro cell culture. The ASCs in PGH also show upregulated expression of genes associated with angiogenesis and wound healing. From a rat full-thickness wound healing model, a wound treated with PGH/ASCs can accelerate the wound closure rate compared with wounds treated with PGH, alginate wound dressing, and gauze. From H&E and Masson’s trichrome staining, the PGH/ASC treatment can promote wound healing by increasing the epithelialization rate and forming well-organized dermis. This is supported by immunohistochemical staining of macrophages and α-smooth muscle actin, where early recruitment of macrophages, macrophage polarization, and angiogenesis was found due to the delivered ASCs. The content of type III collagen is also higher than type I collagen within the newly formed skin tissue, implying scarless wound healing. Taken together, using PGH FMS as a topical wound dressing material for the therapeutic delivery of ASCs, a wound treated with PGH/ASCs was shown to accelerate wound healing significantly in rats, through modulating immunoreaction, promoting angiogenesis, and reducing scar formation at the wound sites. Full article
(This article belongs to the Special Issue Therapeutic Potential of Adipose-Derived Stem Cells)
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21 pages, 3314 KiB  
Article
Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel
by Elle Koivunotko, Jasmi Snirvi, Arto Merivaara, Riina Harjumäki, Swarna Rautiainen, Minna Kelloniemi, Kirsi Kuismanen, Susanna Miettinen, Marjo Yliperttula and Raili Koivuniemi
Biomedicines 2022, 10(10), 2584; https://doi.org/10.3390/biomedicines10102584 - 15 Oct 2022
Cited by 5 | Viewed by 2999
Abstract
Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies by having immunomodulatory behavior and tissue regenerative properties. Due to the capability of ASCs to differentiate into endothelial cells (ECs) and other angiogenic cell types, such as pericytes, ASCs are a highly [...] Read more.
Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies by having immunomodulatory behavior and tissue regenerative properties. Due to the capability of ASCs to differentiate into endothelial cells (ECs) and other angiogenic cell types, such as pericytes, ASCs are a highly valuable source for stimulating angiogenesis. However, cellular therapies in tissue engineering have faced challenges in poor survival of the cells after transplantation, which is why a protective biomaterial scaffold is required. In this work, we studied the potential of nanofibrillated cellulose (NFC) hydrogel to be utilized as a suitable matrix for three-dimensional (3D) cell culturing of human-derived ASCs (hASCs) and studied their angiogenic properties and differentiation potential in ECs and pericytes. In addition, we tested the effect of hASC-conditioned medium and stimulation with angiopoietin-1 (Ang-1) on human umbilical vein endothelial cells (HUVECs) to induce blood vessel-type tube formation in NFC hydrogel. The hASCs were successfully 3D cell cultured in NFC hydrogel as they formed spheroids and had high cell viability with angiogenic features. Most importantly, they showed angiogenic potential by having pericyte-like characteristics when differentiated in EC medium, and their conditioned medium improved HUVEC viability and tube formation, which recalls the active paracrine properties. This study recommends NFC hydrogel for future use as an animal-free biomaterial scaffold for hASCs in therapeutic angiogenesis and other cell therapy purposes. Full article
(This article belongs to the Special Issue Therapeutic Potential of Adipose-Derived Stem Cells)
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Review

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17 pages, 1264 KiB  
Review
Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis
by Ting-Hui Chang, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang and Hsiu-Jung Liao
Biomedicines 2022, 10(7), 1725; https://doi.org/10.3390/biomedicines10071725 - 18 Jul 2022
Cited by 20 | Viewed by 3916
Abstract
Patients with rheumatoid arthritis (RA), a chronic inflammatory joint disorder, may not respond adequately to current RA treatments. Mesenchymal stem cells (MSCs) elicit several immunomodulatory and anti-inflammatory effects and, thus, have therapeutic potential. Specifically, adipose-derived stem cell (ADSC)-based RA therapy may have considerable [...] Read more.
Patients with rheumatoid arthritis (RA), a chronic inflammatory joint disorder, may not respond adequately to current RA treatments. Mesenchymal stem cells (MSCs) elicit several immunomodulatory and anti-inflammatory effects and, thus, have therapeutic potential. Specifically, adipose-derived stem cell (ADSC)-based RA therapy may have considerable potency in modulating the immune response, and human adipose tissue is abundant and easy to obtain. Paracrine factors, such as exosomes (Exos), contribute to ADSCs’ immunomodulatory function. ADSC-Exo-based treatment can reproduce ADSCs’ immunomodulatory function and overcome the limitations of traditional cell therapy. ADSC-Exos combined with current drug therapies may provide improved therapeutic effects. Using ADSC-Exos, instead of ADSCs, to treat RA may be a promising cell-free treatment strategy. This review summarizes the current knowledge of medical therapies, ADSC-based therapy, and ADSC-Exos for RA and discusses the anti-inflammatory properties of ADSCs and ADSC-Exos. Finally, this review highlights the expanding role and potential immunomodulatory activity of ADSC-Exos in patients with RA. Full article
(This article belongs to the Special Issue Therapeutic Potential of Adipose-Derived Stem Cells)
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