Axonal Pathology: From Cellular Mechanism to Therapy Targets
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 6526
Special Issue Editor
Special Issue Information
Dear Colleagues,
Loss of neurons represents the pathological event in neurodegenerative diseases. In the nervous system, axons convey the communication between neurons. The great sizes of axons make them vulnerable to various insults. Thus far, the majority of studies for potential mechanisms and therapeutic targets for neurodegenerative disorders have focused on events that occur in the cell bodies of neurons. However, white matter defects have been identified as an early neuropathological event, leading to axonal degeneration and eventual death of neurons in many neurodegenerative diseases.
Therefore, we invite authors to submit original research and review articles that focus on the molecular mechanisms and therapeutic potential of axonal pathology. Potential topics include but are not limited to:
- Dystrophic neurite/axonal degeneration
- Cytoskeleton integrity
- Microtubule-based transport
- Ubiquitin–proteasome system
- Autophagy–lysosome system
- Growth factor signaling
- Mitochondria
Dr. Lu-Shiun Her
Guest Editor
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Keywords
- dystrophic neurite
- microtubule-based transport
- ubiquitin-proteasome system
- autophagy-lysosome system
- mitochondria
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