3D Printing for Biomedical Applications

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 6267

Special Issue Editor


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Guest Editor
1. Nano-Bio Regenerative Medical Institute, Hallym University, Chuncheon 200-702, Korea
2. Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 200-704, Korea
Interests: biomaterials; silk fibroin; Bio 3D printing, organ on a chip; micrpfludics
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Special Issue Information

Dear Colleague,

Recently, 3D printer technology has gained enormous attention as a preferred application in many sectors, especially for use in biomedical applications. This technology has been applied in several biomedical fields, including patient-specific implants, complex-shaped organ printing, tissue engineering, disease models for better understanding via modeling and imaging, drug development, and the delivery and printing of surgical devices. In the recent past, bio 3D printing technology has progressed toward the aim of fabricating increasingly complex structures with different tissue components and intrinsic microvasculature. Bio 3D printing permits cells, biomaterials, and bioactive molecules to be placed in a precise manner to create a complex 3D tissue structure for biological and clinical applications. Therefore, it is prerequisite to develop a suitable bio-ink with biocompatibility, biodegradability and printability for clinical applications. Although 3D printing technology has gained much attention for biomedical applications, there are still various significant engineering challenges to overcome, including the construction of complex organs and tissues, microfluidics devices, and organs on chips, as well as a lack of bioinks with biocompatibility and printability. Therefore, we would like to welcome any original research articles contributing to the development of bioink, innovative cutting-edge 3D printing technologies, and their diverse application in biomedical fields. We would also like to invite review articles from global experts working in this area, particularly on the latest technological advances on the use 3D printing in biomedical applications.

Dr. Chan Hum Park
Guest Editor

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Keywords

  • Bio 3D printing
  • Bioink
  • Disease model
  • 3D-printed microfluidic devices
  • Organ on a chip
  • Complex organs and tissues
  • Patient-specific implants
  • 3D-printed surgical devices

Published Papers (2 papers)

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Review

21 pages, 6820 KiB  
Review
Three-Dimensional Digital Light-Processing Bioprinting Using Silk Fibroin-Based Bio-Ink: Recent Advancements in Biomedical Applications
by Md. Tipu Sultan, Ok Joo Lee, Joong Seob Lee and Chan Hum Park
Biomedicines 2022, 10(12), 3224; https://doi.org/10.3390/biomedicines10123224 - 12 Dec 2022
Cited by 13 | Viewed by 2488
Abstract
Three-dimensional (3D) bioprinting has been developed as a viable method for fabricating functional tissues and organs by precisely spatially arranging biomaterials, cells, and biochemical components in a layer-by-layer fashion. Among the various bioprinting strategies, digital light-processing (DLP) printing has gained enormous attention due [...] Read more.
Three-dimensional (3D) bioprinting has been developed as a viable method for fabricating functional tissues and organs by precisely spatially arranging biomaterials, cells, and biochemical components in a layer-by-layer fashion. Among the various bioprinting strategies, digital light-processing (DLP) printing has gained enormous attention due to its applications in tissue engineering and biomedical fields. It allows for high spatial resolution and the rapid printing of complex structures. Although bio-ink is a critical aspect of 3D bioprinting, only a few bio-inks have been used for DLP bioprinting in contrast to the number of bio-inks employed for other bioprinters. Recently, silk fibroin (SF), as a natural bio-ink material used for DLP 3D bioprinting, has gained extensive attention with respect to biomedical applications due to its biocompatibility and mechanical properties. This review introduces DLP-based 3D bioprinting, its related technology, and the fabrication process of silk fibroin-based bio-ink. Then, we summarize the applications of DLP 3D bioprinting based on SF-based bio-ink in the tissue engineering and biomedical fields. We also discuss the current limitations and future perspectives of DLP 3D bioprinting using SF-based bio-ink. Full article
(This article belongs to the Special Issue 3D Printing for Biomedical Applications)
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21 pages, 2001 KiB  
Review
Expanding Quality by Design Principles to Support 3D Printed Medical Device Development Following the Renewed Regulatory Framework in Europe
by Livia Adalbert, S P Yamini Kanti, Orsolya Jójárt-Laczkovich, Hussein Akel and Ildikó Csóka
Biomedicines 2022, 10(11), 2947; https://doi.org/10.3390/biomedicines10112947 - 16 Nov 2022
Cited by 3 | Viewed by 3138
Abstract
The vast scope of 3D printing has ignited the production of tailored medical device (MD) development and catalyzed a paradigm shift in the health-care industry, particularly following the COVID pandemic. This review aims to provide an update on the current progress and emerging [...] Read more.
The vast scope of 3D printing has ignited the production of tailored medical device (MD) development and catalyzed a paradigm shift in the health-care industry, particularly following the COVID pandemic. This review aims to provide an update on the current progress and emerging opportunities for additive manufacturing following the introduction of the new medical device regulation (MDR) within the EU. The advent of early-phase implementation of the Quality by Design (QbD) quality management framework in MD development is a focal point. The application of a regulatory supported QbD concept will ensure successful MD development, as well as pointing out the current challenges of 3D bioprinting. Utilizing a QbD scientific and risk-management approach ensures the acceleration of MD development in a more targeted way by building in all stakeholders’ expectations, namely those of the patients, the biomedical industry, and regulatory bodies. Full article
(This article belongs to the Special Issue 3D Printing for Biomedical Applications)
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