The Advances of Cold Plasma in the Biomedicines 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 6104

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Department of Oral Anatomy, School of Dentistry, Pusan National University, Yangsan 50612, Korea
Interests: tissue regeneration; cancer treatment; detal treatment; plasma medical device
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Special Issue Information

Dear Colleagues,

Plasma used in industrial fields requires a vacuum state and can generate high heat. When the temperature of the plasma is less than 250 degrees Celsius, it is called low-temperature plasma. In order to be treated on human tissues, the temperature of the plasma must be less than 40 degrees Celsius. In that respect, it has recently been referred to as cold plasma. The definition of plasma in a biomedical sense seems align more appropriately with cold plasma than low-temperature atmospheric pressure plasma or non-thermal plasma. Therefore, in this Special Issue, I look forward to the unified usage of the term “cold plasma”.

Plasma medicine, which started when cold plasma was applied to bacteria and cells, has made considerable progress over the past 20 years. The scope of plasma research has expanded from just killing pathogens and cancer cells to tissue regeneration and selective cancer cell death. Among the numerous constituents of plasma, studies on which ones have medical functions and the mechanisms by which plasma-induced biomedical phenomena depend on are being actively conducted. Plasma medical devices are being developed based on these studies, and it is expected that various plasma medical devices will be introduced to the medical market in the near future.

In the current research climate, this Special Issue calls for advanced plasma medicine research results by not only explaining various life phenomena induced by plasma, but also cellular or histologic mechanisms. The scope of the research subject is limited to bacteria living in animals, animal cells and tissues, and biomaterials that can be inserted into the human body. Experimental papers and review papers consistent with this research topic are both eligible.

Prof. Dr. Gyoocheon Kim
Guest Editor

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Keywords

  • cold plasma (non-thermal plasma, low temperature plasma)
  • pathogen sterilization
  • regeneration
  • disease treatment
  • medical device
  • biomaterial

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Published Papers (2 papers)

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Research

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12 pages, 3146 KiB  
Article
Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice
by Seoul-Hee Nam, Jeong-Hae Choi and Gyoo-Cheon Kim
Biomedicines 2023, 11(6), 1563; https://doi.org/10.3390/biomedicines11061563 - 27 May 2023
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Abstract
Ultraviolet (UV) is the main cause of sunburn on the skin as it induces erythema and accelerates pigmentation. Vitamin C is one of the most frequently used compounds to reduce UV-induced skin pigmentation, but it has limitations in absorption through the skin. In [...] Read more.
Ultraviolet (UV) is the main cause of sunburn on the skin as it induces erythema and accelerates pigmentation. Vitamin C is one of the most frequently used compounds to reduce UV-induced skin pigmentation, but it has limitations in absorption through the skin. In this study, we tested whether a no-ozone cold plasma (NCP) treatment can improve UV-irradiated skin by helping the action of Vitamin C. For this, among five groups of HRM-2 hairless mice, four groups of mice were subjected to UVB irradiation, and three groups of UVB-treated mice were treated with NCP, Vitamin C, and NCP + Vitamin C, respectively. For evaluating the effect of each treatment, the melanin and erythema index was measured during animal experiments. Histological changes were monitored by performing H&E and MTS and IHC against tyrosinase and melanin. As a result, the naturally recovered mice showed a 28-point decrease in the melanin index, whereas a decrease of around 88, 74.3, and 106 points was detected in NCP-, Vitamin C-, and NCP + vitamin C-treated mice, respectively. Likewise, only a 39-point reduction in the erythema index was monitored in naturally recovered mice, but the NCP-, vitamin C-, and NCP + vitamin C-treated mice showed a 87.3-, 77-, and 111-point reduction, respectively. Interestingly, the skin tissues of the mice treated with NCP in combination with Vitamin C mostly recovered from UVB-induced damage. Altogether, this study elucidated the beneficial effect of the treatment of NCP in combination with Vitamin C on the UVB-irradiated skin, which might be helpful for treating sunburn on the skin. Full article
(This article belongs to the Special Issue The Advances of Cold Plasma in the Biomedicines 2.0)
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Review

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12 pages, 3354 KiB  
Review
Plasma Scalpels: Devices, Diagnostics, and Applications
by Ao Xiao, Dawei Liu, Dongcheng He, Xinpei Lu and Kostya (Ken) Ostrikov
Biomedicines 2022, 10(11), 2967; https://doi.org/10.3390/biomedicines10112967 - 17 Nov 2022
Cited by 10 | Viewed by 3683
Abstract
The plasma scalpel is an application of gas discharges in electrosurgery. This paper introduces the device structure and physicochemical parameters of the two types of plasma scalpels, namely, a single-electrode Ar discharge device (argon plasma coagulation) and a two-electrode discharge device in normal [...] Read more.
The plasma scalpel is an application of gas discharges in electrosurgery. This paper introduces the device structure and physicochemical parameters of the two types of plasma scalpels, namely, a single-electrode Ar discharge device (argon plasma coagulation) and a two-electrode discharge device in normal saline. The diagnostic methods, including the voltage and current characteristics, optical emission spectroscopy, electron spin resonance, and high-speed imaging, are introduced to determine the critical process parameters, such as the plasma power, the gas temperature, the electron density, and the density of active species, and study the ignition dynamics of the plasma discharges in water. The efficacy of the plasma scalpel is mainly based on the physical effects of the electric current and electric field, in addition to the chemical effects of high-density energetic electrons and reactive species. These two effects can be adjusted separately to increase the treatment efficacy of the plasma scalpel. Specific guidance on further improvements of the plasma scalpel devices is also provided. Full article
(This article belongs to the Special Issue The Advances of Cold Plasma in the Biomedicines 2.0)
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