Diagnosis, Pathogenesis and Treatment of Pancreatic Ductal Adenocarcinoma
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 2250
Special Issue Editors
Interests: pancreatic cancer; pancreatic ductal adenocarcinoma; pancreatic surgery; hepatobiliary surgery; colorectal surgery; surgical oncology
Special Issues, Collections and Topics in MDPI journals
Interests: pancreatic cancer; pancreatic ductal adenocarcinoma; pancreatic surgery; hepatobiliary surgery; cholangiocarcinoma; hepatocellular carcinoma; liver metastases; colorectal surgery; surgical oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, originating from the epithelial cells of the main pancreatic duct.
The pathogenesis of PDAC is not fully understood, but includes various risk factors such as genetic predisposition, chronic pancreatitis, smoking, obesity, and diabetes. Genetic mutations play a significant role in the development of PDAC, with KRAS, TP53, and CDKN2A among the most commonly altered genes.
Treatment for PDAC depends on the stage of the cancer and the patient's overall health status. Early stage disease may be treated with surgical resection, while later stages or metastatic PDAC might require chemotherapy, radiation therapy, or targeted therapy. Novel treatment approaches, such as immunotherapy and personalized medicine, are being explored in order to improve patient outcomes.
This Special Issue aims to provide an overview of the advancements in preclinical and clinical practices in the field of the treatment of PDAC. We invite authors to submit original research and review articles focusing on this important topic.
Dr. Teresa Perra
Prof. Dr. Alberto Porcu
Guest Editors
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Keywords
- pancreatic cancer
- pancreatic ductal adenocarcinoma
- treatment
- management
- complications
- vascular reconstruction
- neoadjuvant therapy
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