Advanced Research of HLA in Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1603
Special Issue Editor
2. Centre of Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania
Interests: immunology; molecular biology; virology
Special Issue Information
Dear Colleagues,
The HLA gene cluster is highly polymorphic and strongly associated with various immune diseases. HLA controls the immune response by encoding important antigen-presenting markers and other proteins of the innate and adaptative immune system.
Recently, scientific research has established strong relationships between specific HLA alleles and different diseases. Early studies focused on the relationship between ankylosing spondylitis and HLA-B*27 underlying the immunogenetic background of this disorder.
Other works have demonstrated connections between HLA genes and autoimmune diseases ( i.e., Celiac disease: HLA-DQA1*05:01, HLA-DQB1*02:01, HLA-DQB1*02:02).
In Crohn's disease, the revealed HLA allele profile was DRB1∗04:05, DRB1∗04:10, DQA1∗03, DQB1∗04:01, and DQB1∗ 04:02.
The HLA gene complex has also been positively associated with the risk of infectious disease onset and development like in chronic hepatitis C virus infection: HLA A*23:01, B*44:02, C*04:02.
Other significant associations include examples like chronic renal diseases: B*40, C*12, C*15, and DRB1*14.
Chronic lymphocytic leukemia has been associated with HLA-DRB1*04:02:01 and HLA-DRB3*02:01:01. HLA-B*57:01 is associated with drug hypersensitivity to carbamazepine and abacavir. This is clinically relevant for treatment selection.
This evidence illustrates the significant role of HLA genes in diseases, both in terms of diagnostics and treatment response. Further research is needed for a better understanding of the molecular mechanisms underlying these associations with specific HLA molecules.
Prof. Dr. Ileana Constantinescu
Guest Editor
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