Tissue Engineering and Cell Therapy for Cartilage Repair

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1238

Special Issue Editor


E-Mail Website
Guest Editor
Dermatologische Klinik und Poliklinik, Universitätsspital Zürich, 8091 Zurich, Switzerland
Interests: biomaterials; mesenchymal stem cells; chondrocytes; hydrogels; immunomodulation; cartilage bioreactor; chondrogenesis; osteoarthritis; regenerative medicine

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to gather publications in order to present a comprehensive overview of the current state-of-the-art techniques, advancements, and challenges in the field of tissue engineering and cell therapy for cartilage repair.

Cartilage is a critical component of our musculoskeletal system, providing cushioning and flexibility to joints. However, it has limited regenerative capabilities, making cartilage injuries and degenerative conditions a significant challenge to treat. In recent years, tissue engineering and cell therapy have emerged as promising approaches for cartilage repair, aiming to restore damaged or degenerated cartilage and improve overall joint function. However, challenges remain, including achieving proper integration with the host tissue, ensuring long-term durability of the repaired cartilage, and addressing potential immune responses.

Despite these challenges, the field of tissue engineering and cell therapy for cartilage repair continues to advance rapidly, with ongoing research focusing on refining scaffold materials, optimizing cell sources, and developing innovative techniques to enhance the effectiveness of these approaches. The ultimate goal is to provide patients with more durable, functional, and personalized solutions for cartilage repair, potentially revolutionizing the treatment of cartilage-related disorders and improving the quality of life for individuals with joint injuries and degenerative conditions.

This Special Issue welcomes original article and reviews in several topics, including, but not limited to, the following:

  1. Novel biomaterials and scaffolds for cartilage tissue engineering.
  2. Stem cell-based approaches for cartilage repair and regeneration.
  3. Preclinical and clinical studies on tissue-engineered cartilage.
  4. Strategies for promoting integration with host tissue and mitigating immune responses.
  5. Advancements in bioreactor technologies for cartilage tissue culture.

Dr. Reihane Ziadlou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • cell therapy
  • cartilage repair
  • regenerative medicine
  • chondrogenesis
  • osteoarthritis
  • hydrogels
  • cartilage tissue-engineering strategies
  • cartilage tissue regeneration

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

19 pages, 2898 KiB  
Review
High Hopes for the Biofabrication of Articular Cartilage—What Lies beyond the Horizon of Tissue Engineering and 3D Bioprinting?
by Yordan Sbirkov, Murad Redzheb, Nico Forraz, Colin McGuckin and Victoria Sarafian
Biomedicines 2024, 12(3), 665; https://doi.org/10.3390/biomedicines12030665 - 15 Mar 2024
Viewed by 1021
Abstract
Technologies and biomaterials for 3D bioprinting have been developing extremely quickly in the past decade as they hold great potential in tissue engineering. This, together with the possibility to differentiate stem cells of different origin into any cell type, raises the hopes in [...] Read more.
Technologies and biomaterials for 3D bioprinting have been developing extremely quickly in the past decade as they hold great potential in tissue engineering. This, together with the possibility to differentiate stem cells of different origin into any cell type, raises the hopes in regenerative medicine once again after the initial breakthrough with stem cells in the 1980s. Nevertheless, three decades of 3D bioprinting experiments have shown that the production of functional tissues would take a longer time than anticipated. Cartilage, one of the simplest tissues in the body, consists of only one cell type. It is not vascularised and innervated and does not have lymphatic vessels either, which makes it a perfect target tissue for successful implantation. The tremendous amount of work since the beginning of this century, combining the efforts of bioengineers, material scientists, biologists, and physicians, has culminated in multiple proof-of-concept constructs that have been implanted in animals. However, there is no single reproducible, standardised, widely accessible and accepted strategy that can be readily applied in the clinic. In this review, we focus on the current progress in the field of the 3D biofabrication of articular cartilage and critically assess failures and future challenges. Full article
(This article belongs to the Special Issue Tissue Engineering and Cell Therapy for Cartilage Repair)
Show Figures

Figure 1

Back to TopTop