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Biomedicines
Special Issues
Molecular Research on Osteoarthritis and Osteoporosis
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Molecular Research on Osteoarthritis and Osteoporosis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1846

Special Issue Editor

Dr. Bo Qiu

E-Mail Website
Guest Editor
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China
Interests: osteoarthritis; chondrocyte; inflammation; MSC; signaling pathways
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Osteoarthritis is a degenerative joint disease that affects millions worldwide, leading to chronic pain, impaired mobility, and reduced quality of life. Complementary to this, osteoporosis is a systemic skeletal disorder characterized by reduced bone density, increased risk of fractures, and substantial morbidity. Both diseases pose significant challenges to public health, necessitating a comprehensive understanding of their underlying molecular mechanisms to develop effective prevention strategies, diagnostics, and therapeutic interventions.

This Special Issue aims to provide a comprehensive platform for researchers and scholars to contribute original research articles, reviews, and perspectives addressing the molecular aspects of osteoarthritis and osteoporosis. The objective is to deepen our understanding of the underlying cellular and molecular processes involved in these conditions, ultimately leading to improved diagnostic, prevention, and treatment strategies.

We welcome submissions focusing on various aspects, including, but not limited to, the following:

  • The molecular pathways and signaling mechanisms underlying osteoarthritis and osteoporosis development and progression.
  • The identification and characterization of biomarkers for early detection, prognosis, and monitoring of these diseases.
  • Emerging therapeutic targets and novel molecular interventions to alleviate symptoms and halt disease progression.
  • Epigenetic modifications, gene expression regulation, and non-coding RNAs associated with the pathogenesis of osteoarthritis and osteoporosis.
  • Advances in genomics, proteomics, and metabolomics studies to unravel the intricate molecular interactions involved in these diseases.
  • Animal models, cell culture systems, and innovative molecular tools employed in osteoarthritis and osteoporosis research.

We encourage researchers from diverse disciplines, including molecular biology, biochemistry, genetics, and pharmaceutics, to contribute and collaborate in advancing our knowledge in this field. We also invite clinicians to present their perspectives on translating molecular research findings into clinical applications for the benefit of patients.

Dr. Bo Qiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • osteoporosis
  • signaling pathway
  • therapeutic target
  • genomics
  • metabolomics
  • animal model
  • epigenetic modifications

Published Papers (3 papers)

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Research

12 pages, 569 KiB  
Article
The Effect of Denosumab on Rotator Cuff Repair in Women Aged 60 and over with Osteoporosis: A Prospective Observational Study
by Ki-Tae Kim, Sanghyeon Lee, Ho-Won Lee, Shi-Hyun Kim and Yong-Beom Lee
Biomedicines 2024, 12(5), 1069; https://doi.org/10.3390/biomedicines12051069 - 12 May 2024
Viewed by 312
Abstract
Background: In previous studies, denosumab, a RANKL human monoclonal antibody used in osteoporosis treatment, has shown efficacy in tendon healing after rotator cuff repair. This prospective study investigated the effects of denosumab on tendon healing, re-tear rates, and clinical outcomes post rotator cuff [...] Read more.
Background: In previous studies, denosumab, a RANKL human monoclonal antibody used in osteoporosis treatment, has shown efficacy in tendon healing after rotator cuff repair. This prospective study investigated the effects of denosumab on tendon healing, re-tear rates, and clinical outcomes post rotator cuff repair in women with osteoporosis. Method: This was a prospective, observational study, employing propensity score matching for the control group. From March 2018 to March 2023, female patients over the age of 60 with normal bone density undergoing arthroscopic rotator cuff repair were selected as controls through propensity score matching (PSM) and compared with female patients of the same age group with osteoporosis who were receiving denosumab treatment. The control group was matched using 1-to-2 propensity score matching. Radiological examinations and functional outcomes were assessed preoperatively and at 6 months postoperatively. Results: In the final analysis, the study comprised 34 patients in the denosumab treatment group (Group 1) and 68 patients in the control group (Group 2). The functional scores showed significant improvement at 6 months post-surgery in both groups. No significant difference in the functional scores was observed among the groups. The re-tear rate, defined according to Sugaya’s classification (types IV and V) as re-tear, was slightly higher in Group 1 at 16.7% (6 of 34) compared to Group 2 at 11.7% (8 of 68), but the difference was not statistically significant (p = 0.469). The re-tear patterns, classified according to Rhee’s classification, also showed no significant difference among the groups (Group 1: 2/4 of 6; Group 2: 4/4 of 8; p = 0.571). The occurrence of type I re-tear exhibited no significant difference between the two groups (5.9% vs. 5.9%; p = 1.000). Conclusions: The administration of denosumab following arthroscopic rotator cuff repair in women aged 60 and over with osteoporosis resulted in a re-tear rate that was similar to that observed in patients without osteoporosis. This result suggests that denosumab administration might be beneficial for rotator cuff healing, particularly in the context of osteoporosis, a known risk factor for increased retear rates. Therefore, comprehensive osteoporosis screening and treatment should be considered in conjunction with rotator cuff repair surgery in middle-aged women. Full article
(This article belongs to the Special Issue Molecular Research on Osteoarthritis and Osteoporosis)
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11 pages, 1206 KiB  
Article
Cartilage Collagen Neoepitope C2C Expression in the Articular Cartilage and Its Relation to Joint Tissue Damage in Patients with Knee Osteoarthritis
by Taavi Torga, Siim Suutre, Kalle Kisand, Marina Aunapuu and Andres Arend
Biomedicines 2024, 12(5), 1063; https://doi.org/10.3390/biomedicines12051063 - 11 May 2024
Viewed by 268
Abstract
Pathological cleavage of type II collagen (Col2) and generation of Col2 neoepitopes can serve as useful molecular markers of the progression of osteoarthritis (OA). One of such potential biomarkers is type II collagen neoepitope C2C. The aim of this study was to correlate [...] Read more.
Pathological cleavage of type II collagen (Col2) and generation of Col2 neoepitopes can serve as useful molecular markers of the progression of osteoarthritis (OA). One of such potential biomarkers is type II collagen neoepitope C2C. The aim of this study was to correlate the degree of articular cartilage damage in OA patients with C2C expression in histological samples of tissues removed during total knee replacement. Cartilage samples were obtained from 27 patients ranging in age from 55 to 66 years. In each patient, medial and lateral tibia plateau samples were analyzed according to the OARSI histopathology grading system. The C2C expression was evaluated on histological slides by semi-quantitative analysis using ImageJ Fiji 2.14.0 software. Spearman’s rank correlation analysis revealed a positive weak correlation (rho = 0.289, p = 0.0356) between the histological grade of tissue damage and the percentage of C2C staining. In addition, a highly significant positive correlation (rho = 0.388, p = 0.0041) was discovered between the osteoarthritis score (combining the histological grade of damage with the OA macroscopic stage) and the percentage of C2C staining in the samples. The C2C expression was detected in all the regions of the articular cartilage (i.e., the superficial zone, mid zone, deep zone and tidemark area, and the zone of calcified cartilage). Our findings imply that local expression of C2C correlates with the articular cartilage damage in OA-affected knees. This confirms that C2C can be used as a prospective marker for assessing pathological changes in the OA course and OA clinical trials. Full article
(This article belongs to the Special Issue Molecular Research on Osteoarthritis and Osteoporosis)
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16 pages, 2481 KiB  
Article
Using Macrophage Polarization in Human Platelet Lysate to Test the Immunomodulatory Potential of Cells for Clinical Use
by Silvia Lopa, Francesca Libonati, Katia Mareschi, Giuseppe Talò, Stefania Brambilla, Vincenzo Raffo, Luciana Labanca, Luigi Zagra, Matteo Moretti, Laura de Girolamo and Alessandra Colombini
Biomedicines 2024, 12(4), 833; https://doi.org/10.3390/biomedicines12040833 - 9 Apr 2024
Viewed by 579
Abstract
Macrophage-based co-cultures are used to test the immunomodulatory function of candidate cells for clinical use. This study aimed to characterize a macrophage polarization model using human platelet lysate (hPL) as a GMP-compliant alternative to Fetal Bovine Serum (FBS). Primary human monocytes were differentiated [...] Read more.
Macrophage-based co-cultures are used to test the immunomodulatory function of candidate cells for clinical use. This study aimed to characterize a macrophage polarization model using human platelet lysate (hPL) as a GMP-compliant alternative to Fetal Bovine Serum (FBS). Primary human monocytes were differentiated into unpolarized (M0) or polarized (M1, M2a, and M2c) macrophages in an hPL- or FBS-based medium. The protein secretion profiles and expression of phenotypic markers (CD80 for M1, CD206 for M2a, and CD163 for M2c) were analyzed. Subsequently, chondrocytes were tested in an hPL-based co-culture model to assess their immunomodulatory function in view of their possible use in patients with osteoarthritis. The results showed similar marker regulation between hPL and FBS cultures, but lower basal levels of CD206 and CD163 in hPL-cultured macrophages. Functional co-culture experiments with chondrocytes revealed increased CD206 expression both in hPL and in FBS, indicating an interaction between macrophages and chondrocytes. While markers in FBS-cultured macrophages were confirmed in hPL-cultured cells, the interpretation of marker modulation in immunomodulatory assays with hPL-based cultures should be carried out cautiously due to the observed differences in the basal marker levels for CD206 and CD163. This research underscores the utility of hPL as a GMP-compliant alternative to FBS for macrophage-based co-cultures and highlights the importance of understanding marker expressions in different culture conditions. Full article
(This article belongs to the Special Issue Molecular Research on Osteoarthritis and Osteoporosis)
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