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Biomedicines
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Recent Advances in Obesity-Related Metabolic Diseases: 2nd Edition
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Recent Advances in Obesity-Related Metabolic Diseases: 2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1772

Special Issue Editor

Dr. Sandip Mukherjee

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Guest Editor
Division of Geriatrics and Nutritional Science, Washington University in St. Louis, 660 S. Euclid Ave., St. Louis, MO 63110, USA
Interests: obesity; metabolism; insulin resistance; adipose tissue; liver; NAD metabolism; mitochondria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of obesity has significantly increased in the past few decades because of sedentary life styles and limited physical activity. Obesity is now considered a global epidemic disease. Obesity is a chronic disease that can cause or aggravate co-morbidities including type two diabetes mellitus (T2DM), hypertension, cardiovascular disease (CVD), metabolic dysfunction-associated steatotic liver disease (MAFLD), metabolic dysfunction-associated steatohepatitis (MASH), and certain other diseases.

The major contributor of obesity-induced metabolic dysfunction includes dysfunction of adipose tissue, liver, skeletal muscle, gut, and brain. Unfortunately, we do not have a comprehensive knowledge about these individual organs and their cross-talk during pathological conditions. Enormous research has been conducted and is also actively pursuing a search for novel targets which could be pharmacologically targeted to combat these diseases.

The Special Issue aims to summarize research studies involving obesity and associated comorbidities. The major focus is studies reporting novel pathways or targets in obesity. Translational studies including pre-clinical studies with rodents and human subjects are also encouraged in this issue.

Original research articles include (but not limited to) deciphering novel pathways with molecular mechanisms, unravelling the role of unknown or less-characterized proteins in obesity metabolism, and exploring the function of adipose tissue, liver, heart, and muscle.

Dr. Sandip Mukherjee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • metabolism
  • adipose tissue
  • liver inflammation
  • hyperglycemia
  • hyperlipidemia
  • cardiovascular diseases
  • new drug targets
  • translational studies

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Related Special Issue

Published Papers (2 papers)

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Research

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15 pages, 1505 KB  
Article
Vitamin D Status in Patients at the Department of Internal, Autoimmune, and Metabolic Diseases—A Descriptive Cross-Sectional Study
by Zuzanna Pawlus, Patryk Mosiołek, Karolina Bierć, Aleksandra Pilśniak, Agata Janoska-Gawrońska and Michał Holecki
Biomedicines 2025, 13(9), 2170; https://doi.org/10.3390/biomedicines13092170 - 5 Sep 2025
Viewed by 356
Abstract
Background: Vitamin D plays a crucial role in numerous physiological systems, including the muscular, immune, and endocrine systems, as well as calcium and bone homeostasis. Vitamin D deficiency, a global health problem affecting billions of people, is associated with adverse health outcomes and [...] Read more.
Background: Vitamin D plays a crucial role in numerous physiological systems, including the muscular, immune, and endocrine systems, as well as calcium and bone homeostasis. Vitamin D deficiency, a global health problem affecting billions of people, is associated with adverse health outcomes and can serve as a marker for health status, disease severity, and length of hospital stay (LOS). Nutritional supplementation has been shown to be highly beneficial and is strongly recommended. Methods: In this study, the medical records of 834 hospitalized patients were retrospectively analyzed, with a focus on 25-hydroxyvitamin D [25(OH)D] levels. The patients were divided into groups based on serum vitamin D levels: deficient, suboptimal, adequate, and high. Correlations between vitamin D levels, LOS, laboratory parameters, comorbidities, seasonal variations, medical diagnosis of deficiency, and supplementation were examined. Results: Vitamin D deficiency was common and associated with a longer LOS. Women had higher vitamin D levels than men. No seasonal variation was observed. Only 14% of the patients took supplements before hospitalization, and 61% of the patients with vitamin D deficiency received supplementation. Conclusions: Routine vitamin D screening, tailored supplementation, and increased public awareness are essential to reduce hospitalizations, improve treatment outcomes, and promote independence among at-risk groups. Full article
(This article belongs to the Special Issue Recent Advances in Obesity-Related Metabolic Diseases: 2nd Edition)
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Review

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38 pages, 1649 KB  
Review
The Gut Microbiome in Human Obesity: A Comprehensive Review
by Alejandro Borrego-Ruiz and Juan J. Borrego
Biomedicines 2025, 13(9), 2173; https://doi.org/10.3390/biomedicines13092173 - 5 Sep 2025
Viewed by 1122
Abstract
An estimated 2.6 billion individuals are currently living with overweight or obesity, and this number is projected to exceed 4 billion by 2035. Consequently, unless this increasing trajectory is effectively addressed, the trend is expected to continue in the coming years. The gut [...] Read more.
An estimated 2.6 billion individuals are currently living with overweight or obesity, and this number is projected to exceed 4 billion by 2035. Consequently, unless this increasing trajectory is effectively addressed, the trend is expected to continue in the coming years. The gut microbiome has emerged as a central regulator of host metabolism and energy homeostasis, making its detailed characterization crucial for the advancement of innovative therapeutic strategies and for elucidating mechanisms underlying metabolic health and disease. This review examines human obesity through the lens of the gut microbiome, providing a comprehensive overview of its role by addressing gut microbiome alterations, microbiome-driven mechanisms, dietary influences, prebiotic effects, microbiome-based therapeutics, and other approaches in the treatment of obesity and related metabolic disorders. The composition of the gut microbiome is altered in obesity and characterized by reduced microbial diversity and inconsistent shifts in dominant bacterial phyla, which collectively contribute to metabolic dysregulation. The gut microbiome influences obesity through multiple mechanisms. These include regulating energy balance and insulin sensitivity via short-chain fatty acids, inducing chronic inflammation, modulating metabolic and appetite genes, altering bile acid signaling, and promoting fat storage by inhibiting fasting-induced adipose factor. Dietary patterns exert a profound influence on gut microbiome composition and function, with plant-based diets conferring protective effects against obesity and its comorbidities. Microbiome-based therapeutics, including probiotics, synbiotics, and fecal microbiota transplantation, have demonstrated potential in modulating key metabolic and inflammatory pathways associated with obesity. As the scientific understanding of the human gut microbiome continues to advance, the integration of microbiome-based therapies into standard clinical practice is poised to become increasingly feasible and therapeutically transformative, particularly for obesity, a complex condition that demands innovative and customized interventions. Full article
(This article belongs to the Special Issue Recent Advances in Obesity-Related Metabolic Diseases: 2nd Edition)
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