Advancements in Induced Pluripotent Stem Cells

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 923

Special Issue Editor


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Guest Editor
Head of Translational Research with iPS Cells Group, Research Institute Hospital 12 de Octubre, i+12, Madrid, Spain
Interests: induced pluripotent stem cells; McArdle disease; mitochondrial disorders; modeling disorders; CRISPR/Cas9; drug repurposing studies; tissue engineering
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Special Issue Information

Dear Colleagues,

Since the creation of induced pluripotent stem cells (iPSCs), by the Nobel Prize laureate Dr. Shinya Yamanaka, many laboratories worldwide are working to generate and apply these cells to the investigation of the ethiopathogeny behind diseases and the search for new therapies against them. The aim of this Special Issue is to collect high-quality papers, fully dedicated to iPSCs and their applications, from top experts in this field. We particularly encourage researchers to submit comprehensive review papers and original articles that showcase the latest advancements in this area. By doing so, we aim to create a collection of high-quality papers that explore the potential of iPSCs and shed light on their diverse applications in addressing various challenges in medical research and treatment.

Dr. M. Esther Gallardo
Guest Editor

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Keywords

  • induced pluripotent stem cells
  • organoids
  • tissue engineering
  • biomaterials
  • reprogramming
  • iPSC-based cell modelling
  • cell therapy
  • microfluidics
  • drug discovery

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Published Papers (1 paper)

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Review

14 pages, 2450 KiB  
Review
Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles in Liver Injury
by Jingjing Dong, Ying Luo and Yingtang Gao
Biomedicines 2024, 12(11), 2489; https://doi.org/10.3390/biomedicines12112489 - 30 Oct 2024
Viewed by 463
Abstract
Liver injury caused by various factors significantly impacts human health. Stem cell transplantation has potential for enhancing liver functionality, but safety concerns such as immune rejection, tumorigenesis, and the formation of emboli in the lungs remain. Recent studies have shown that stem cells [...] Read more.
Liver injury caused by various factors significantly impacts human health. Stem cell transplantation has potential for enhancing liver functionality, but safety concerns such as immune rejection, tumorigenesis, and the formation of emboli in the lungs remain. Recent studies have shown that stem cells primarily exert their effects through the secretion of extracellular vesicles (EVs). EVs have been shown to play crucial roles in reducing inflammation, preventing cell death, and promoting liver cell proliferation. Additionally, they can function as carriers to deliver targeted drugs to the liver, thereby exerting specific physiological effects. EVs possess several advantages, including structural stability, low immunogenicity, minimal tumorigenicity targeting capabilities, and convenient collection. Consequently, EVs have garnered significant attention from researchers and are expected to become alternative therapeutic agents to stem cell therapy. This article provides a comprehensive review of the current research progress in the use of stem cell-derived EVs in the treatment of liver injury. Full article
(This article belongs to the Special Issue Advancements in Induced Pluripotent Stem Cells)
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