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Biomedicines
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Approaches to Modulate the Effects of Drug Transporters for Drug...
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Approaches to Modulate the Effects of Drug Transporters for Drug Delivery and Development

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1540

Special Issue Editor

Dr. Guru Raghavendra Valicherla

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
Interests: in vitro ADME; in vivo DMPK; drug-drug interactions; PBPK modeling; drug discovery and development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug transporters are important determinants of the pharmacokinetics and pharmacodynamics of drugs. Clinically relevant transporter-mediated drug–drug interactions are of increasing interest in drug development. A proper understanding of drug transporters’ roles in drug disposition allows reliable evaluation/prediction of pharmacokinetics, of changes due to disease progression or genetic polymorphisms, and of drug–drug interactions. This knowledge will be helpful for developing novel combination therapies, prodrug treatments, and formulation strategies for drug delivery.

This Special Issue welcomes original research and/or review articles of drug delivery and development related to the in vitro, in vivo and ex vivo pharmacokinetics, transporter-mediated drug–drug interactions, modulation effects of drug transporters, novel combination therapies, prodrug treatments, formulation strategies for effective drug delivery and in vitro to in vivo correlation and extrapolation (IVIVC/E). This Special Issue will promote mechanistic understanding of transporter interactions with drugs to improve drug delivery and development.  

Dr. Guru Raghavendra Valicherla
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

17 pages, 4634 KiB  
Article
Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats
by Shimaa S. Ramadan, Farah A. El Zaiat, Engy A. Habashy, Mostafa M. Montaser, Habeba E. Hassan, Shahinaz S. Tharwat, Manal El-khadragy, Ahmed E. Abdel Moneim, Gehad E. Elshopakey and Ahmed M. A. Akabawy
Biomedicines 2023, 11(11), 3054; https://doi.org/10.3390/biomedicines11113054 - 14 Nov 2023
Viewed by 1247
Abstract
Exposure to mercuric chloride (HgCl2), either accidental or occupational, induces substantial liver and kidney damage. Coenzyme Q10 (CoQ10) is a natural antioxidant that also has anti-inflammatory and anti-apoptotic activities. Herein, our study aimed to investigate the possible protective effects of CoQ10 [...] Read more.
Exposure to mercuric chloride (HgCl2), either accidental or occupational, induces substantial liver and kidney damage. Coenzyme Q10 (CoQ10) is a natural antioxidant that also has anti-inflammatory and anti-apoptotic activities. Herein, our study aimed to investigate the possible protective effects of CoQ10 alone or loaded with albumin nanoparticles (CoQ10NPs) against HgCl2-induced hepatorenal toxicity in rats. Experimental animals received CoQ10 (10 mg/kg/oral) or CoQ10NPs (10 mg/kg/oral) and were injected intraperitoneally with HgCl2 (5 mg/kg; three times/week) for two weeks. The results indicated that CoQ10NP pretreatment caused a significant decrease in serum liver and kidney function markers. Moreover, lowered MDA and NO levels were associated with an increase in antioxidant enzyme activities (SOD, GPx, GR, and CAT), along with higher GSH contents, in both the liver and kidneys of intoxicated rats treated with CoQ10NPs. Moreover, HgCl2-intoxicated rats that received CoQ10NPs revealed a significant reduction in the hepatorenal levels of TNF-α, IL-1β, NF-κB, and TGF-β, as well as an increase in the hepatic level of the fibrotic marker (α-SMA). Notably, CoQ10NPs counteracted hepatorenal apoptosis by diminishing the levels of Bax and caspase-3 and boosting the level of Bcl-2. The hepatic and renal histopathological findings supported the abovementioned changes. In conclusion, these data suggest that CoQ10, alone or loaded with albumin nanoparticles, has great power in reversing the hepatic and renal tissue impairment induced by HgCl2 via the modulation of hepatorenal oxidative damage, inflammation, and apoptosis. Therefore, this study provides a valuable therapeutic agent (CoQ10NPs) for preventing and treating several HgCl2-induced hepatorenal disorders. Full article
(This article belongs to the Special Issue Approaches to Modulate the Effects of Drug Transporters for Drug Delivery and Development)
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