Advances in Pharmacokinetic Drug–Drug Interactions
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2412
Special Issue Editors
Interests: in vitro ADME; in vivo DMPK; drug-drug interactions; PBPK modeling; drug discovery and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The investigation of drug–drug interactions is essential for drug discovery and development. The important mechanisms for pharmacokinetic drug–drug interactions include the inhibition or induction of drug metabolism and transporters. It is essential to evaluate absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic interactions of novel molecules, and investigational drugs for effective drug development. Remarkable progress has been made over the past few decades in ADME and DMPK tools that can promote the development of novel therapies and advances in understanding the effects of diseases on PK and minimize the potential of drug–drug interactions and reduce attrition rates in drug development. This Special Issue welcomes the submission of original research and/or review articles on drug discovery and development related to the advancements of in vitro, in vivo, and ex vivo ADME and DMPK, in vitro to in vivo correlation and extrapolation (IVIVC/E), biotransformation, drug–drug interactions, and pharmacokinetic interactions related to drug-metabolizing enzymes and drug transporters. This Special Issue will promote a quantitative and mechanistic understanding of the pharmacokinetic interactions of novel drug candidates in biological systems.
Dr. Guru Raghavendra Valicherla
Dr. Jiaur Rahaman Gayen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- liquid chromatography mass spectrometry
- in vitro adme (absorption, distribution, metabolism, excretion)
- in vivo pharmacokinetics and drug metabolism
- drug–drug interactions
- drug metabolizing enzymes
- drug transporters
