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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multidisciplinary Approaches in Complex Ear, Nose and Throat Pathology

edited by

Daniela Vrinceanu

and

Mihai Dumitru

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1338 | Submission Open

Keywords: complex ENT pathology; head and neck cancer; cancer; personalized therapy; trauma; sleep disorders; immune ENT diseases; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Development on Lipid Nanoparticles

edited by

Ligia Ribeiro

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1247 | Submission Open

Keywords: lipid nanoparticles; nanomedicine; drug delivery systems; mRNA delivery; gene therapy; lipid-based carriers; nanoparticle formulation; targeted delivery; vaccine technology; pharmaceutical nanotechnology

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Multidisciplinary Advances in Cancer Care—Innovations in Early Detection, Precision Medicine, and AI Driven Strategies

edited by

Eva Y W Cheung

Ricky Wu

and Ellie S.M. Chu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1231 | Submission Open

Keywords: cancer early detection; multi-cancer screening; liquid biopsy; cancer biomarkers; tumor imaging and prognostics radiomics and artificial intelligence; precision oncology; targeted therapies; immunotherapy and tumor microenvironment; cancer prevention

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in the Diagnosis and Interventional Management of Peripheral Artery Disease: Emerging Technologies, Evidence, and Clinical Pathways

edited by Ioannis Skalidis

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1194 | Submission Open

Keywords: peripheral artery disease; peripheral interventions; atherosclerosis; angioplasty; diagnosis and treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

RNA Therapy in Cancer Treatment: From Design to Clinical Translation

edited by Zhouxiao Li

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1172 | Submission Open

Keywords: mRNA vaccines; RNA interference (siRNA/miRNA); non-coding RNA therapeutics; lipid nanoparticles (LNPs); tumor microenvironment; neoantigen targeting; combination immunotherapy; clinical translation

(This special issue belongs to the Section Gene and Cell Therapy)

Macrophages and Immune Modulation in Cancer Therapy

edited by

Max Kam-Kwan Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: tumor-associated macrophages; macrophage plasticity; macrophage reprogramming; immune modulation; macrophage-targeted therapies; macrophage–stromal interactions

(This special issue belongs to the Section Cancer Biology and Oncology)

Bridging Advanced Research and Clinical Applications: AI and Molecular Insights in Gynecologic Oncology

edited by

Mario Fordellone

and

Marco La Verde

submission deadline 31 Jul 2026 | Viewed by 1066 | Submission Open

Keywords: gynecologic cancer biomarkers; AI-driven molecular analysis; machine learning models; ovarian cancer gene signatures; endometrial cancer profiling; cervical cancer prediction; multi-omics integration; prognostic and predictive algorithms; precision gynecologic oncology; translational bioinformatics

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Single-Cell Sequencing in Diseases

edited by Sedat Kacar

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1063 | Submission Open

Keywords: single-cell sequencing; bioinformatics analysis; spatial transcriptomics; cellular heterogeneity; data-driven discovery; disease biology

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advancing Precision Radiation Oncology in Head and Neck Cancers

edited by

Wing-Keen Yap

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1003 | Submission Open

Keywords: precision radiation oncology; head and neck cancers; oncogenetics; genomic biomarkers; radiosensitivity; adaptive radiotherapy; artificial intelligence; immunotherapy integration; proton therapy; deescalation strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

Cardiac Arrhythmias and Arrhythmogenic Disorders: Pathomechanisms, Diagnostics and Novel Treatment Options

edited by Michela Casella and

Yari Valeri

submission deadline 31 Jul 2026 | 2 articles | Viewed by 969 | Submission Open

Keywords: arrhythmias; arrhythmogenic disorders; cardiomyopathies; genetics; cardiac MRI; atrial fibrillation; premature ventricular contraction; ventricular tachycardia; catheter ablation

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights into Pregnancy Health

edited by Robert Brawura Biskupski Samaha and

Chi Chiu Wang

submission deadline 31 Jul 2026 | 2 articles | Viewed by 951 | Submission Open

Keywords: prenatal diagnosis and treatment; maternal health; factors influencing pregnancy outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Clinical Genetics and Genomics of Neurodegenerative Diseases

edited by

Justin Miller

and

Laura Ibanez

submission deadline 31 Jul 2026 | 1 articles | Viewed by 933 | Submission Open

Keywords: dementia; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; ALS; genetics; genomics; translational medicine; frontotemporal dementia; LATE; prion disease; neurocognitive impairment; GWAS; polygenic risk

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Heart Failure Pharmacotherapy

edited by

Persoulla A. Nicolaou

submission deadline 31 Jul 2026 | 1 articles | Viewed by 842 | Submission Open

Keywords: heart failure; pharmacotherapy; precision medicine; pharmacogenomics; pharmacokinetics; pharmacodynamics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches—2nd Edition

edited by

Lu Li

submission deadline 31 Jul 2026 | 2 articles | Viewed by 815 | Submission Open

Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Radiological and Optical Imaging for Clinical Oncology

edited by

Jia-Sheng Hong

and

Wei-Kai Lee

submission deadline 31 Jul 2026 | Viewed by 775 | Submission Open

Keywords: clinical oncology; medical imaging; artificial intelligence; deep learning; radiomics; image-guided therapy; treatment response; prognosis; optical imaging; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Emerging Strategies in Targeted and Smart Drug Delivery

edited by Candace Day

submission deadline 31 Jul 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: targeted drug delivery; nanoparticles; drug delivery carriers; controlled release; therapeutic agents; drug formulation

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Epigenetic Regulation and Its Impact for Medicine (3rd Edition)

edited by

Marie Černá

submission deadline 31 Jul 2026 | 1 articles | Viewed by 584 | Submission Open

Keywords: gene expression; DNA methylation; histone modifications; non-coding RNAs; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Additive Manufacturing in Biomedical Applications

edited by

Paweł Turek

submission deadline 31 Jul 2026 | Viewed by 564 | Submission Open

Keywords: additive manufacturing; scaffolds; implant; anatomical models; in vivo; in vitro; surface texture; geometrical accuracy; biomaterials; surface roughness

(This special issue belongs to the Section Biomedical Engineering and Materials)

Multiple Sclerosis: Neuro-Technology and New Approaches for Treatment, Diagnosis and Symptom Monitoring

edited by

Michelangelo Dini

and Letizia Leocani

submission deadline 31 Jul 2026 | Viewed by 524 | Submission Open

Keywords: multiple sclerosis; treatment; neuromodulation; digital biomarkers; digital tools; artificial intelligence; wearable sensors; eHealth

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 3rd Edition

edited by

Ana Maria Dascalu

and

Dragos Serban

submission deadline 31 Jul 2026 | 1 articles | Viewed by 507 | Submission Open

Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Unleashing the Power of Innovative Nanoparticles for Enhanced Radiation Therapy

edited by Fangchao Jiang

submission deadline 31 Jul 2026 | Viewed by 491 | Submission Open

Keywords: nanomedicine; drug delivery; radiation therapy; nanotheranostics; nanoparticles; cancer treatment; biomaterial

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Esophageal Cancer: Pathogenesis and Therapeutic Strategies

edited by

Boopathi Subramaniyan

submission deadline 31 Jul 2026 | Viewed by 385 | Submission Open

Keywords: ESCC; EACC; biomarkers; transcription factors; signaling pathways; immune cells; metabolism; animal model; cell lineage and gender

(This special issue belongs to the Section Cancer Biology and Oncology)

Novel Strategies for Oncogene-Addicted Lung Cancers: Not Rare Anymore

edited by

Carminia Maria Della Corte

submission deadline 31 Jul 2026 | Viewed by 374 | Submission Open

Keywords: target therapy; EMT; biomarkers; cancer mutations; preclinical models

(This special issue belongs to the Section Cancer Biology and Oncology)

Structure-Based Drug Molecule Design and Organic Synthesis

edited by

Sateesh Dubbu

submission deadline 31 Jul 2026 | Viewed by 373 | Submission Open

Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Glaucoma: The Mechanisms and Novel Therapeutic Approaches

edited by Samantha Sze Wan Shan

submission deadline 31 Jul 2026 | Viewed by 371 | Submission Open

Keywords: intraocular pressure; ocular hypertension; outflow facility; gene-editing; epigenetic modifications; small RNAs; translational studies; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Skeletal Muscle Ageing: From Molecular Mechanism to Treatment

edited by Can Cui and

Manuela Bozzi

submission deadline 31 Jul 2026 | Viewed by 359 | Submission Open

Keywords: skeletal muscle aging; sarcopenia; muscle regeneration; neuromuscular degeneration; molecular mechanisms of aging; mitochondrial dysfunction; inflammation and aging; therapeutic interventions; exercise and muscle health; musculoskeletal disorders in aging

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuroinflammation: From Mechanisms to Therapeutic Approaches

edited by

Yuen Gao

submission deadline 31 Jul 2026 | Viewed by 357 | Submission Open

Keywords: neuroinflammation; molecular mechanism; cell-free stem-cell-based therapy; anti-inflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Rewiring Immune Fate: Immunometabolic and Epigenetic Mechanisms in Therapeutic Immunomodulation in Inflammation, Aging, and Cancer

edited by

Sandip Ashok Sonar

and

Thoihen Heikrujam

submission deadline 31 Jul 2026 | Viewed by 346 | Submission Open

Keywords: immunotherapy; cell therapy; immunometabolism; epigenetic reprogramming; chronic inflammation; immunosenescence; anti-cancer immunity; regeneration of the immune system; system biology of immunometabolism; tumor microenvironment; neuroimmune communication; graft versus host diseases; stromal regulation of structure and function of lymphoid organs

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Research of Chronic Kidney Disease

edited by Jingyuan Xie

submission deadline 31 Jul 2026 | Viewed by 342 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; biomarker discovery; inflammation; fibrosis; genetic kidney disease; glomerulonephritis; diabetic nephrology

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathomechanisms of Disturbances Underlying Chronic Disorders—Third Edition

edited by

Dorota Formanowicz

submission deadline 31 Jul 2026 | Viewed by 340 | Submission Open

Keywords: chronic disorders; atherosclerosis; inflammation; oxidative stress; lipoproteins; endothelial dysfunction; biomarkers; pathomechanisms

(This special issue belongs to the Section Immunology and Immunotherapy)

Diagnostic Biomarkers and Novel Therapeutics Targets for Fragile X Syndrome, Autism Spectrum Disorders and Genetic Neurodevelopmental Diseases: Advances and Challenges, 2nd Edition

edited by Yolanda De Diego-Otero and Rocio Calvo-Medina

submission deadline 31 Jul 2026 | Viewed by 328 | Submission Open

Keywords: fragile X syndrome; autism spectrum disorders; neurodevelopmental disorders; developmental neuroscience; cognitive development

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress and Challenges in Heart Transplantation

edited by Ricardo Gimeno Costa

submission deadline 31 Jul 2026 | Viewed by 318 | Submission Open

Keywords: heart transplantation; donor selection; organ utilization; immunosuppression; rejection management; emerging therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Dopamine and Androgen Receptor Signaling: Novel Insights in Cancer Biology

edited by Srijan Acharya

submission deadline 31 Jul 2026 | Viewed by 311 | Submission Open

Keywords: dopamine signaling; androgen receptor; cancer biology; hormone-sensitive tumors; signal transduction; tumor microenvironment; neurotransmitters in cancer; prostate cancer; breast cancer; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Cardiac Dysfunction: From Early Detection to Innovative Therapies

edited by

Carla Contaldi

submission deadline 31 Jul 2026 | Viewed by 300 | Submission Open

Keywords: cardiac dysfunction; heart failure; early detection; advanced heart failure; advanced cardiac imaging; biomarkers; innovative therapies; risk stratification; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Insights into Musculoskeletal Diseases

edited by

Simon Fuk-Tan Tang

submission deadline 31 Jul 2026 | Viewed by 299 | Submission Open

Keywords: musculoskeletal diseases; myopathies; tendinopathy, tissue engineering; echo-guided injection, regenerative medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomedical Applications of Microfluidics

edited by

Surjendu Maity

submission deadline 31 Jul 2026 | Viewed by 297 | Submission Open

Keywords: microfluidics; organ-on-a-chip; lab-on-a-chip; disease modeling; regenerative medicine; cancer immunotherapy; biosensors; mathematical modeling; AI/ML; realtime sensing

(This special issue belongs to the Section Biomedical Engineering and Materials)

Pathogenesis and Therapeutic Intervention of Alzheimer's Disease

edited by Chanchal Sharma

submission deadline 31 Jul 2026 | Viewed by 294 | Submission Open

Keywords: dementia; Alzheimer’s disease; neuroinflammation; microglia; gene therapy; stem cells; blood–brain barrier; oxidative stress; gut-microbiome; diet; artificial intelligence

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Natural Products in Cancer Research: From Traditional Medicine to Modern Drugs

edited by Chih-Jui Chang and

Che-Hsin Lee

submission deadline 31 Jul 2026 | Viewed by 286 | Submission Open

Keywords: natural products; cancer therapy; tranditional Chinese medicine (TCM); pharmacology; precision oncology; tanslational research

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

The Role of Immunity and Inflammation in Cardiovascular Diseases

edited by

Radu Sebastian Gavril

and

Florin Mitu

submission deadline 31 Jul 2026 | Viewed by 278 | Submission Open

Keywords: cardiovascular diseases; immunity; inflammation; atherosclerosis; vascular remodeling; biomarkers; microbiome; immunomodulation; targeted therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Precision Microbiome Modulation for Metabolic and Inflammatory Diseases

edited by

Sidharth Mishra

submission deadline 31 Jul 2026 | Viewed by 274 | Submission Open

Keywords: gut microbiome; systemic inflammation; insulin resistance; non-alcoholic fatty liver disease (NAFLD); neuroinflammation; metabolic syndrome

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advanced Research in Neuroprotection: 2nd Edition

edited by

Christos Bakirtzis

and Evangelia Kesidou

submission deadline 31 Jul 2026 | Viewed by 271 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood–brain barrier

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

State-of-the-Art Cancer Biology, Biodiagnostics and Therapeutics in Japan—Second Edition

edited by

Takaaki Hirotsu

Eric Di Luccio

and Hideshi Ishii

submission deadline 31 Jul 2026 | Viewed by 270 | Submission Open

Keywords: cancer biology; epigenetics; early detection; diagnosis; biodiagnosis; novel therapeutics; new paradigms

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Diagnosis and Genomic Insights in Cancer

edited by Jingjing Hu

submission deadline 31 Jul 2026 | Viewed by 266 | Submission Open

Keywords: oncogenes; gene therapy; next-generation sequencing (NGS); targeted therapy; personalized medicine; cancer diagnosis; cancer therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

State of the Art on Demyelinating Diseases in Latin America

edited by

Víctor M. Rivera

and Liliana Patrucco

submission deadline 31 Jul 2026 | Viewed by 262 | Submission Open

Keywords: demyelinating disorders; multiple sclerosis; neuromyelitis optica spectrum disorder; MOG antibody-associated disease; IgG-Aquarin-4 antibody; anti-MOG antibody; acute disseminated encephalomyeloitis; MRI; cerebrospinal fluid; steroids; disease modifying therapies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Bioinformatics Analysis of RNA for Human Health and Disease—2nd Edition

edited by

Jihwan Ha

submission deadline 31 Jul 2026 | Viewed by 262 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g., m6A, pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Osteoblast Differentiation in Skeletal Disease States

edited by

Kyeong-Min Kim

and

Won-gu Jang

submission deadline 31 Jul 2026 | Viewed by 254 | Submission Open

Keywords: osteoblast differentiation; bone remodeling; skeletal diseases; inflammation and bone metabolism; cellular stress pathways; mesenchymal stem cells

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research in Myeloproliferative Neoplasms

edited by

Uros Markovic

and

Marco Santoro

submission deadline 31 Jul 2026 | Viewed by 239 | Submission Open

Keywords: myeloproliferative neoplasms; chronic myeloid leukemia; nutrition; symptoms; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Extracellular Vesicles for Diagnosis and Therapy of Human Diseases, 2nd Edition

edited by

Zoran Minic

submission deadline 31 Jul 2026 | Viewed by 238 | Submission Open

Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology

(This special issue belongs to the Section Molecular and Translational Medicine)

Modern Approaches to Breast Cancer Biology and Therapy

edited by Zofia Łapińska and Anna Szewczyk

submission deadline 31 Jul 2026 | Viewed by 227 | Submission Open

Keywords: breast cancer; molecular pathology; hormonal therapy; estrogen receptor signaling; targeted therapies; immunotherapy; electric pulse-based therapies; precision oncology; biomarkers (ER/PR/HER2); multigene testing; combination therapies; therapeutic resistance; novel treatment strategies

(This special issue belongs to the Section Cancer Biology and Oncology)

Advanced Research in Hypertrophic Cardiomyopathy (2nd Edition)

edited by Said Alsidawi,

Juan Maria Farina

and