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Biomolecules
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The Role of Arginine and Arginine Metabolites in Cerebro- and...
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The Role of Arginine and Arginine Metabolites in Cerebro- and Cardiovascular Disease Targeted Therapy

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 1461

Special Issue Editors

Prof. Dr. Edzard Schwedhelm

E-Mail Website
Guest Editor
Institute for Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
Interests: biomarkers of cardiovascular diseases; vasoactive messenger and drug intervention; arginine metabolism as a therapeutic target
Prof. Dr. Arduino A. Mangoni

E-Mail Website
Guest Editor
Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedfor Park, SA 5042, Australia
Interests: drug and biomarker discovery; drug repurposing; aging; cancer; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals
Dr. Roman N. Rodionov

E-Mail Website
Guest Editor
Associate Professor, Department of Internal Medicine III, Technische Universität Dresden, 01307 Dresden, Germany
Interests: novel cardiovascular risk factors; endogenous non-proteinogenic amino acids; cardiovascular remodelling
Dr. Ying Wang

E-Mail Website
Guest Editor
Assistant Professor, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA
Interests: endothelial cells; vascular intergrity; inflammation

Special Issue Information

Dear Colleagues,

Cerebro- and cardiovascular diseases are still the leading causes of death worldwide. While the pharmacological treatment of risk factors like hypertension, hyperlipidaemia, diabetes and thrombosis has reduced the risk at the population level, there is a lack of individualized treatment options. In recent years, potential therapeutic targets related to the arginine/nitric oxide/cyclic guanosine monophosphate pathway have been identified. Understanding functional and mechanistic principles to elucidate the underlying (patho)mechanisms of those biomolecules will be the focus of this Special Issue.

We would like to invite you to contribute your research and review manuscripts that report on molecules (small and large) that are precursors, inhibitors or metabolites of the nitric oxide/cyclic guanosine monophosphate pathway and novel therapeutic targets. This includes the identification, validation, and pre-clinical application of biomarkers in innovative diagnostic procedures, drug discovery/development and disease pathogenesis.

We look forward to reading your contributions.

Prof. Dr. Edzard Schwedhelm
Prof. Dr. Arduino A. Mangoni
Dr. Roman N. Rodionov
Dr. Ying Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alanine:glyoxylate aminotransferase 2
  • asymmetric dimethylarginine
  • cyclic guanosine monophosphate
  • dimethylarginine dimythylaminohydrolase 1
  • homoarginine
  • nitric oxide
  • symmetric dimethylarginine

Published Papers (1 paper)

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Research

15 pages, 1697 KiB  
Article
Diurnal Variation of L-Arginine and the Cardiovascular Risk Markers Asymmetric and Symmetric Dimethylarginine and Homoarginine in Rotating Night Shift Workers and Controls
by Juliane Hannemann, Debra J. Skene, Benita Middleton, Edzard Schwedhelm, Anika Laing and Rainer Böger
Biomolecules 2023, 13(9), 1282; https://doi.org/10.3390/biom13091282 - 22 Aug 2023
Viewed by 1242
Abstract
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) interfere with nitric oxide (NO) formation from L-arginine via different mechanisms. ADMA is a biomarker of cardiovascular disease and mortality, whilst SDMA is a biomarker of mortality after ischemic stroke. Homoarginine, another L-arginine-derived amino acid, is [...] Read more.
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) interfere with nitric oxide (NO) formation from L-arginine via different mechanisms. ADMA is a biomarker of cardiovascular disease and mortality, whilst SDMA is a biomarker of mortality after ischemic stroke. Homoarginine, another L-arginine-derived amino acid, is associated with stroke and congestive heart failure. Acute ischemic events like myocardial infarction show a time-of-day variation in the timing of their onset, as do NO-mediated vascular function and blood pressure. We studied whether the plasma concentrations of L-arginine-related amino acid metabolites show diurnal variation in a clinical study comparing 12 non-night shift workers with 60 rotating night shift workers. The plasma concentrations of L-arginine-related biomarkers, melatonin, and cortisol were measured every 3 h during a 24-h period. In addition, 24-h blood pressure recordings were performed. In non-night shift workers, L-arginine and homoarginine plasma concentrations showed diurnal variation with a 12-h period, which were both attenuated in night shift workers. ADMA and SDMA showed a 24-h rhythmicity with no significant differences in phase between night shift and non-night shift workers. The plasma profiles of melatonin and cortisol were not significantly different between both groups, suggesting that the rotating night shift work does not have a major influence on central suprachiasmatic nuclei clock timing. In addition, systolic and diastolic blood pressure patterns were similar between both groups. Our data show diurnal variation of dimethylarginines with the timing of their acrophases corresponding to the published timing of the peak incidence of cardiac ischemic events. Full article
(This article belongs to the Special Issue The Role of Arginine and Arginine Metabolites in Cerebro- and Cardiovascular Disease Targeted Therapy)
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