Cytokine Signaling in Immunity and Immune Cell-Mediated Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 433

Special Issue Editors


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Guest Editor
School of Medicine, Faculty of Health, Locked Bag 20000, Geelong, Deakin University, Geelong, VIC 3220, Australia
Interests: cytokine receptors; hematopoiesis; cytokines; zebrafish
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Special Issue Information

Dear Colleagues,

Cytokines represent a paradigm in cell-cell communication and play particularly important roles in cells within the immune system. These proteins are able to transmit signals via their respective receptors into specific immune cell populations to influence key processes, including development, survival and function. Such signals must be finely balanced to maintain a healthy immune system. Disruption of this balance underpins a number of disorders, ranging from immune deficiency to inflammation and autoimmunity to leukemia, lymphoma and other malignancies. This Special Issue will publish studies that highlight the pivotal role played by cytokine signals in normal immunity and their disruption in immune-related diseases

Prof. Dr. Alister C. Ward
Dr. Clifford Liongue
Guest Editors

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Keywords

  • cytokine
  • cytokine receptor
  • immunity
  • interleukin
  • signal transduction

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Published Papers (1 paper)

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Review

20 pages, 3105 KiB  
Review
Binding Molecules in Tick Saliva for Targeting Host Cytokines, Chemokines, and Beyond
by Chamberttan Souza Desidério, Victor Hugo Palhares Flávio-Reis, Yago Marcos Pessoa-Gonçalves, Rafael Destro Rosa Tiveron, Helioswilton Sales-Campos, Andrei Giacchetto Felice, Siomar de Castro Soares, Rhainer Guillermo-Ferreira, Wellington Francisco Rodrigues and Carlo José Freire Oliveira
Biomolecules 2024, 14(12), 1647; https://doi.org/10.3390/biom14121647 (registering DOI) - 21 Dec 2024
Abstract
Ticks have coevolved with their hosts over millions of years, developing the ability to evade hemostatic, inflammatory, and immunological responses. Salivary molecules from these vectors bind to cytokines, chemokines, antibodies, complement system proteins, vasodilators, and molecules involved in coagulation and platelet aggregation, among [...] Read more.
Ticks have coevolved with their hosts over millions of years, developing the ability to evade hemostatic, inflammatory, and immunological responses. Salivary molecules from these vectors bind to cytokines, chemokines, antibodies, complement system proteins, vasodilators, and molecules involved in coagulation and platelet aggregation, among others, inhibiting or blocking their activities. Initially studied to understand the complexities of tick–host interactions, these molecules have been more recently recognized for their potential clinical applications. Their ability to bind to soluble molecules and modulate important physiological systems, such as immunity, hemostasis, and coagulation, positions them as promising candidates for future therapeutic development. This review aims to identify the binding molecules present in tick saliva, determine their primary targets, and explore the tick species involved in these processes. By associating the binding molecules, the molecules to which they bind, and the effect caused, the review provides a basis for understanding how these molecules can contribute to possible future advances in clinical applications. Full article
(This article belongs to the Special Issue Cytokine Signaling in Immunity and Immune Cell-Mediated Diseases)
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