Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 4787
Special Issue Editors
Interests: determine the pathophysiological function and regulatory mechanism of noncoding RNAs (e.g., microRNA and regulatory elements in mRNA untranslated regions); RNA-binding proteins in cardiac system and cardiovascular disorders
Interests: muscle structure and function; cardiomyopathies; RNA metabolism; protein trafficking
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases are being recognized at an accelerating frequency and are a cause of heart failure. The major types of cardiovascular diseases include coronary artery disease (CAD), peripheral artery disease (PAD), stroke, and heart diseases such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), genetic cardiomyopathy, and ischemic cardiomyopathy (caused by myocardial infarction). For instance, in cardiomyopathy, the heart muscle becomes enlarged, thick, or rigid, which can lead to other cardiac conditions such as valve problems, blood clots, heart failure, cardiac arrest, and sudden death. The underlying molecular and cellular mechanisms of pathological changes and transition from cardiovascular disease to cardiomyopathy and heart failure remain poorly defined. In addition, congenital defects in vascular and cardiac development can cause cardiovascular disease. The role of translation machinery and the subsequent translational control of protein synthesis is increasingly attracting researchers’ attention in the field of cardiovascular systems and related diseases. Translational regulations occur when ribosomes are loaded to mature mRNAs by translation initiation factors, followed by translation elongation for decoding individual genetic codons to translate mRNA into a protein product. This process includes the translation preinitiation complex binding to the 5’ cap and scanning through the 5’ untranslated region (UTR), ribosome assembly at the start codons to initiate translation, ribosome-directed translation elongation on the coding sequence (CDS), and translation termination at the stop codon, involving translational control by many trans-acting RNA-binding proteins, translation factors, kinases, and signaling molecules. Thus, we invite investigators to contribute original research articles and review articles focused on the role of translation machinery and translational control in physiological homeostasis and pathological changes in the cardiovascular system.
Potential topics include, but are not limited to, the following:
- Translational control of cardiovascular development and diseases;
- Function and mechanism of translation factors and RNA-binding proteins in the pathological changes in the cardiovascular system;
- Role of non-coding RNAs in the regulation of protein synthesis in cardiovascular disease and heart failure;
- Signaling pathways in translational regulation to the structural and functional alterations of the heart and blood vessels;
- Novel translation-manipulating therapeutic approaches in cardiovascular disease.
Dr. Peng Yao
Dr. Wei Guo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- translational control
- translation machinery
- RNA-binding protein
- non-coding RNA
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
