Molecular Basis and Oxidative Stress of Thyroid Diseases

Dear Colleagues,

We are pleased to announce a forthcoming Special Issue of Biomolecules entitled "Molecular Basis and Oxidative Stress of Thyroid Diseases." This Special Issue aims to gather the most recent research on the molecular mechanisms and the role of oxidative stress in the etiology and progression of thyroid diseases.
Thyroid cancer, thyroid dysfunction (hypo- and hyperthyroidism), and different types of thyroidisis and autoimmune thyroid diseases (such as Hashimoto thyroiditis or Graves' disease) are complex conditions affected by genetic, environmental, and immunological factors. Recent studies have highlighted the significant impact of oxidative stress—an imbalance between reactive oxygen species (ROS) formation and antioxidant defense—on thyroid health. Understanding the molecular basis of these diseases and the potential contribution of oxidative stress can improve diagnostic and therapeutic strategies.

We invite you to contribute your valuable research to this Special Issue. Key topics of interest include, but are not limited to:

1.  Molecular Mechanisms of Thyroid Hormone Synthesis and Regulation: Insights into the genes, proteins, and cellular processes involved in the biosynthesis, secretion, and regulation of thyroid hormones.
2. Oxidative Stress and Thyroid Dysfunction: Studies on how ROS influence thyroid pathology, affecting thyroid cell function, hormone synthesis, and immune response in thyroid diseases.
3. Genetic and Epigenetic Factors: Research on genetic mutations, polymorphisms, and epigenetic modifications that predispose individuals to thyroid disorders, providing insights into hereditary aspects and potential biomarkers.
4. Immune System and Inflammation: Exploring the relationship between oxidative stress and the immune system in autoimmune thyroid diseases and understanding the molecular basis of immune response and mechanism of inflammation in different types of thyroiditis.
5. Antioxidant Defence Mechanisms: Examination of the body's antioxidant defense in the context of thyroid health, including the role of enzymes, vitamins, and other molecules that mitigate oxidative damage and looking for their potential therapeutic application.
6. Novel Therapeutic Approaches: Development of new treatment strategies targeting oxidative stress and its molecular pathways in thyroid disorders, encompassing pharmacological intervention and lifestyle modification to reduce oxidative stress.

We look forward to receiving your valuable contributions and to working together to advance the field of thyroid disease research.

Prof. Dr. Małgorzata Karbownik-Lewińska
Dr. Jan Stȩpniak
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• thyroid diseases
• oxidative stress
• reactive oxygen species (ROS)
• thyroid hormone synthesis
• molecular mechanisms
• genetic mutations
• epigenetic modifications
• autoimmune thyroid diseases
• Hashimoto thyroiditis
• Graves' disease