Properties and Functions of Endometrial Stromal Cells

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Reproduction".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1128

Special Issue Editors


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Guest Editor
School of Pharmaceutical Science, Ohu University, Fukushima 963-8611, Japan
Interests: placentation; implantation; endogenous retrovirus; gene expression; transfection; cell culture; gene regulation; PCR; DNA; cloning

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Guest Editor
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Interests: phosphorylation; signaling; endocrinology; proteins; p53; cell differentiation; apoptosis; protein kinases; signaling pathways; reproductive endocrinology

Special Issue Information

Dear Colleagues,

The endometrium is the reproductive tissue lining the uterus and undergoes extensive cyclic growth, regeneration, differentiation, and shedding throughout the menstrual cycle in response to steroid hormones. Endometrium abnormalities may be associated with repeated embryonic implantation failure, recurrent spontaneous abortions, and other physiological features contributing to female infertility. We hope that this Special Issue, titled "Properties and Functions of Endometrial Stromal Cells", will serve as a stepping stone to propose solutions for the abnormalities resulting from endometrial dysfunction in humans. This Special Issue welcomes your contributions in the form of original articles, reviews, or perspective articles on any aspect of recent advances in reproduction.

Dr. Toshihiro Sakurai
Dr. Mikihiro Yoshie
Guest Editors

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Keywords

  • endometrium
  • endometriosis
  • molecular reproduction
  • implantation
  • decidualization
  • placentation
  • inflammation
  • reproductive endocrinology
  • assisted reproductive technology
  • molecular reproductive biology

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Published Papers (1 paper)

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Research

11 pages, 1974 KiB  
Article
Decidualized Endometrial Stromal Cells Promote Mitochondrial Beta-Oxidation to Produce the Octanoic Acid Required for Implantation
by Yumi Mizuno, Shunsuke Tamaru, Hideno Tochigi, Tomomi Sato, Miyuko Kishi, Akira Ohtake, Osamu Ishihara and Takeshi Kajihara
Biomolecules 2024, 14(8), 1014; https://doi.org/10.3390/biom14081014 - 16 Aug 2024
Viewed by 829
Abstract
Decidualization denotes the morphological and biological differentiating process of human endometrial stromal cells (HESCs). Fatty acid pathways are critical for endometrial decidualization. However, the participation of fatty acids as an energy source and their role in endometrial decidualization have received little attention. To [...] Read more.
Decidualization denotes the morphological and biological differentiating process of human endometrial stromal cells (HESCs). Fatty acid pathways are critical for endometrial decidualization. However, the participation of fatty acids as an energy source and their role in endometrial decidualization have received little attention. To identify fatty acids and clarify their role in decidualization, we comprehensively evaluated free fatty acid profiles using liquid chromatography/Fourier transform mass spectrometry (LC/FT-MS). LC/FT-MS analysis detected 26 kinds of fatty acids in the culture medium of decidualized or un-decidualized HESCs. Only the production of octanoic acid, which is an essential energy source for embryonic development, was increased upon decidualization. The expressions of genes related to octanoic acid metabolism including ACADL, ACADM, and ACADS; genes encoding proteins catalyzing the first step of mitochondrial fatty acid beta-oxidation; and ACSL5 and ACSM5; genes encoding fatty acid synthesis proteins were significantly altered upon decidualization. These results suggest that decidualization promotes lipid metabolism, implying that decidualized HESCs require energy metabolism of the mitochondria in embryo implantation. Full article
(This article belongs to the Special Issue Properties and Functions of Endometrial Stromal Cells)
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